DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and ZNF224

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001308574.1	Gene:	ZNF224 / 7767	HGNCID:	13017	Length:	707	Species:	Homo sapiens

Alignment Length:	893	Identity:	161/893 - (18%)
Similarity:	265/893 - (29%)	Gaps:	349/893 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1087 QNTLQLVPQAQHQVVPHVQLQSQLVPHVQTQGTTTTVTYEQIYQQHIVQQTVQQSSNKMQVISLP 1151
            :|.|.:..||.|:...|.                  :..|:|:......|....|.:|:|.....
Human    42 RNLLSVGHQAFHRDTFHF------------------LREEKIWMMKTAIQREGNSGDKIQTEMET 88

  Fly  1152 SAGSETTRQWQTQQSQQQ-------------QQVQWSSVG--------GLEAI----KSAPVESV 1191
            .:.:.|.::|..||..::             ...|:|..|        ||..|    ||:.....
Human    89 VSEAGTHQEWSFQQIWEKIASDLTRSQDLMINSSQFSKEGDFPCQTEAGLSVIHTRQKSSQGNGY 153

  Fly  1192 APTTTTYYISASDLYPQ---QTETYTMLQPASNESYVIEQVNHQQQHCQQQI--------QMSQQ 1245
            .|:.:.  :|..|.:.|   ..:::|..:...|..|:.....||:.|..::.        :.||.
Human   154 KPSFSD--VSHFDFHQQLHSGEKSHTCDECGKNFCYISALRIHQRVHMGEKCYKCDVCGKEFSQS 216

  Fly  1246 QHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHI------YNAATSNDVHQMQHT 1304
            .|.:.||:....::                          |...      ::..::.:||...||
Human   217 SHLQTHQRVHTGEK--------------------------PFKCVECGKGFSRRSALNVHHKLHT 255

  Fly  1305 QR-----QQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLK 1364
            ..     ::..:.:.|.  .:||:.|:                 |.|...|            .|
Human   256 GEKPYNCEECGKAFIHD--SQLQEHQR-----------------IHTGEKP------------FK 289

  Fly  1365 CRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSH 1429
            |..|  |..|......:||.: :|.|..||.|..|..:|..|:..:.|.:.|...:.|:|.:|..
Human   290 CDIC--GKSFCGRSRLNRHSM-VHTAEKPFRCDTCDKSFRQRSALNSHRMIHTGEKPYKCEECGK 351

  Fly  1430 VFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSER----RPRGRPYKPRLQLQQHQLQPQ 1490
            .|..::.|..|    ||.                 .|.|:    :..|:.::....|.:||
Human   352 GFICRRDLYTH----HMV-----------------HTGEKPYNCKECGKSFRWASCLLKHQ---- 391

  Fly  1491 QKLQVQQHQQQQ--------KALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQ-HQ 1546
                 :.|..::        |......|...||:....:...:.::..:..:.::....||: |
Human   392 -----RVHSGEKPFKCEECGKGFYTNSQCYSHQRSHSGEKPYKCVECGKGYKRRLDLDFHQRVH- 450

  Fly  1547 QVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAP 1611
                                           |..|:.   :|::|....|.|
Human   451 -------------------------------TGEKLY---NCKECGKSFSRA------------- 468

  Fly  1612 PTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVAS 1676
            |.:|                  :|..:.|.|:
Human   469 PCLL------------------KHERLHSGEK--------------------------------- 482

  Fly  1677 PSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKH 1741
                                                         ...|..|.:|||....|..|
Human   483 ---------------------------------------------PFQCEECGKRFTQNSHLHSH 502

  Fly  1742 HQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVH 1806
            .::..|   ..||.|..|.:||..:..|..|.:.|..| |||.|..|...|...|.|..|: .:|
Human   503 QRVHTG---EKPYKCEKCGKGYNSKFNLDMHQKVHTGE-RPYNCKECGKSFGWASCLLKHQ-RLH 562

  Fly  1807 LLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-------- 1862
            ...||..|:||||:|...|.|.:|.:.| ||..|:||.|.:.|.:......|:|.||
Human   563 SGEKPFKCEECGKRFTQNSQLHSHQRVHTGEKPYKCDECGKGFSWSSTRLTHQRRHSRETPLKCE 627

  Fly  1863 ---------------------EMFYKCKFCPSSFMRFTNFRAHMKTHL 1889
                                 |..|||:.|...:.|..|...|.:.|:
Human   628 QHGKNIVQNSFSKVQEKVHSVEKPYKCEDCGKGYNRRLNLDMHQRVHM 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1725..1746	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
ZNF224	NP_001308574.1	KRAB	8..67	CDD:214630	8/42 (19%)
		KRAB	8..47	CDD:279668	2/4 (50%)
		C2H2 Zn finger	178..198	CDD:275368	4/19 (21%)
		COG5048	202..641	CDD:227381	118/677 (17%)
		C2H2 Zn finger	206..226	CDD:275368	5/19 (26%)
		zf-H2C2_2	218..243	CDD:290200	4/50 (8%)
		C2H2 Zn finger	234..254	CDD:275368	2/19 (11%)
		C2H2 Zn finger	262..282	CDD:275368	4/38 (11%)
		zf-H2C2_2	275..297	CDD:290200	10/52 (19%)
		C2H2 Zn finger	290..310	CDD:275368	6/22 (27%)
		C2H2 Zn finger	318..338	CDD:275368	5/19 (26%)
		C2H2 Zn finger	346..366	CDD:275368	7/40 (18%)
		C2H2 Zn finger	374..394	CDD:275368	4/28 (14%)
		C2H2 Zn finger	402..422	CDD:275368	4/19 (21%)
		C2H2 Zn finger	430..450	CDD:275368	2/19 (11%)
		C2H2 Zn finger	458..478	CDD:275368	7/50 (14%)
		zf-H2C2_2	471..495	CDD:290200	8/119 (7%)
		C2H2 Zn finger	486..506	CDD:275368	7/19 (37%)
		C2H2 Zn finger	514..534	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..549	CDD:290200	9/23 (39%)
		C2H2 Zn finger	542..562	CDD:275368	6/20 (30%)
		zf-H2C2_2	555..579	CDD:290200	11/24 (46%)
		C2H2 Zn finger	570..590	CDD:275368	9/19 (47%)
		zf-H2C2_2	585..606	CDD:290200	8/20 (40%)
		C2H2 Zn finger	598..618	CDD:275368	6/19 (32%)
		C2H2 Zn finger	654..674	CDD:275368	5/19 (26%)
		C2H2 Zn finger	682..702	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100