DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and ZNF184

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001305820.1	Gene:	ZNF184 / 7738	HGNCID:	12975	Length:	751	Species:	Homo sapiens

Alignment Length:	1048	Identity:	191/1048 - (18%)
Similarity:	327/1048 - (31%)	Gaps:	396/1048 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   936 ENIETPEE-----GQNLHLELTQF-----LRDL-------QPSQSDPPAGEQVEKIEMETQPSTV 983
            |::.:|:.     |.|| |....|     .:|:       :..|.||...:....:.:|.....|
Human     2 EDLSSPDSTLLQGGHNL-LSSASFQEAVTFKDVIVDFTQEEWKQLDPGQRDLFRDVTLENYTHLV 65

  Fly   984 QMDVQSNLPVQAADTQPQNESANHSPFESPISSPQVQSQIELQMEPQIETQMQPQI--------E 1040
            .:.:|                         :|.|.|.||:|...||.|   |:|.|        |
Human    66 SIGLQ-------------------------VSKPDVISQLEQGTEPWI---MEPSIPVGTCADWE 102

  Fly  1041 TRMQHDVLSVQSPQNHQPQVQSHDQSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQHQVVPHVQ 1105
            ||:::   ||.:|   :|.:...           ::.|::.|:..:::.               .
Human   103 TRLEN---SVSAP---EPDISEE-----------ELSPEVIVEKHKRDD---------------S 135

  Fly  1106 LQSQLVPHVQTQGTTTTVTYEQIYQQHIVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQQ 1170
            ..|.|:...:.:|:        :.:|...|||:.:.. |:...::||        |:......
Human   136 WSSNLLESWEYEGS--------LERQQANQQTLPKEI-KVTEKTIPS--------WEKGPVNN-- 181

  Fly  1171 QVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNE------------- 1222
                      |..||..|.|...|        .:..|::|.|...::..||.
Human   182 ----------EFGKSVNVSSNLVT--------QEPSPEETSTKRSIKQNSNPVKKEKSCKCNECG 228

  Fly  1223 ---SYVIEQVNHQQQH----------CQQQIQMSQQ--QHQRQHQQQQAQQQQQPIMILIQQPEI 1272
               ||....:.||:.|          |::....|:.  .|||.|...:..:..|.....|:.|.:
Human   229 KAFSYCSALIRHQRTHTGEKPYKCNECEKAFSRSENLINHQRIHTGDKPYKCDQCGKGFIEGPSL 293

  Fly  1273 QQPVASASNPQQAPLHIYNAATSNDVHQMQHTQRQQIRQQY----------------QHQQYQRL 1321
            .|.....:..:.........|.|...|.:||.:.....:.|                :||:....
Human   294 TQHQRIHTGEKPYKCDECGKAFSQRTHLVQHQRIHTGEKPYTCNECGKAFSQRGHFMEHQKIHTG 358

  Fly  1322 QQP-----------QQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFS 1375
            ::|           :.|.:.|...:                 .|..:    |.||..|  |..|:
Human   359 EKPFKCDECDKTFTRSTHLTQHQKI-----------------HTGEK----TYKCNEC--GKAFN 400

  Fly  1376 SSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVH 1440
            ....:.||.: :|....|:.|..|..||:..:..:||..:|...:.|.|.:|...|....:|..|
Human   401 GPSTFIRHHM-IHTGEKPYECNECGKAFSQHSNLTQHQKTHTGEKPYDCAECGKSFSYWSSLAQH 464

  Fly  1441 IQRFHMTLKTDPSGAVKVEDVQLQITSERRPR-----GRPYKPRLQLQQHQLQPQQKLQVQQHQQ 1500
                                  |:|.:..:|.     |:.:.....|.||:         :.|.:
Human   465 ----------------------LKIHTGEKPYKCNECGKAFSYCSSLTQHR---------RIHTR 498

  Fly  1501 QQ--------KALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQ 1557
            ::        ||...|.....|   |:...|::..:..:..:..::.....:|:::...::|.|
Human   499 EKPFECSECGKAFSYLSNLNQH---QKTHTQEKAYECKECGKAFIRSSSLAKHERIHTGEKPYQ- 559

  Fly  1558 PLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIV 1622
                                          |.:|....|:.
Human   560 ------------------------------CHECGKTFSYG------------------------ 570

  Fly  1623 SVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSST 1687
                                       ::|.|:||          :|
Human   571 ---------------------------SSLIQHRK----------IH------------------ 580

  Fly  1688 VDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTM 1752
                      |...|                    :.|..|...|...|.|.:|.::..||   .
Human   581 ----------TGERP--------------------YKCNECGRAFNQNIHLTQHKRIHTGA---K 612

  Fly  1753 PYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDEC 1817
            ||.|..|.:.:|..::|.:|.::| .|.:||:||.|...|.:.|.||.|: .:|...||:.|:||
Human   613 PYECAECGKAFRHCSSLAQHQKTH-TEEKPYQCNKCEKTFSQSSHLTQHQ-RIHTGEKPYKCNEC 675

  Fly  1818 GKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTN 1880
            .|.|...:.|..|...| ||..|.|:.|.:||.....|.:|:|.|| |..:.|..|..||...:.
Human   676 DKAFSRSTHLTEHQNTHTGEKPYNCNECRKTFSQSTYLIQHQRIHSGEKPFGCNDCGKSFRYRSA 740

  Fly  1881 FRAHMKTH 1888
            ...|.:.|
Human   741 LNKHQRLH 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1424..1445	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	7/19 (37%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
ZNF184	NP_001305820.1	KRAB	28..88	CDD:214630	15/84 (18%)
		KRAB	28..67	CDD:279668	6/38 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..212		5/28 (18%)
		C2H2 Zn finger	224..244	CDD:275368	4/19 (21%)
		zf-H2C2_2	236..261	CDD:290200	4/24 (17%)
		COG5048	<248..409	CDD:227381	29/183 (16%)
		C2H2 Zn finger	252..272	CDD:275368	5/19 (26%)
		zf-H2C2_2	264..287	CDD:290200	5/22 (23%)
		C2H2 Zn finger	280..300	CDD:275368	4/19 (21%)
		zf-H2C2_2	292..317	CDD:290200	2/24 (8%)
		C2H2 Zn finger	308..328	CDD:275368	5/19 (26%)
		zf-H2C2_2	320..345	CDD:290200	4/24 (17%)
		C2H2 Zn finger	336..356	CDD:275368	2/19 (11%)
		zf-H2C2_2	348..373	CDD:290200	3/24 (13%)
		COG5048	360..736	CDD:227381	108/578 (19%)
		C2H2 Zn finger	364..384	CDD:275368	2/36 (6%)
		zf-H2C2_2	376..400	CDD:290200	7/46 (15%)
		C2H2 Zn finger	392..412	CDD:275368	6/22 (27%)
		zf-C2H2	418..440	CDD:278523	6/21 (29%)
		C2H2 Zn finger	420..440	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..457	CDD:290200	7/24 (29%)
		C2H2 Zn finger	448..468	CDD:275368	6/41 (15%)
		zf-H2C2_2	460..485	CDD:290200	6/46 (13%)
		C2H2 Zn finger	476..496	CDD:275368	4/28 (14%)
		zf-H2C2_2	488..513	CDD:290200	6/33 (18%)
		C2H2 Zn finger	504..524	CDD:275368	5/22 (23%)
		zf-H2C2_2	516..541	CDD:290200	3/27 (11%)
		C2H2 Zn finger	532..552	CDD:275368	1/19 (5%)
		zf-H2C2_2	544..569	CDD:290200	5/55 (9%)
		C2H2 Zn finger	560..580	CDD:275368	7/80 (9%)
		zf-H2C2_2	572..597	CDD:290200	10/82 (12%)
		C2H2 Zn finger	588..608	CDD:275368	6/19 (32%)
		zf-H2C2_2	600..625	CDD:290200	8/27 (30%)
		C2H2 Zn finger	616..636	CDD:275368	5/19 (26%)
		zf-H2C2_2	628..653	CDD:290200	10/25 (40%)
		C2H2 Zn finger	644..664	CDD:275368	8/20 (40%)
		zf-H2C2_2	656..681	CDD:290200	11/25 (44%)
		C2H2 Zn finger	672..692	CDD:275368	7/19 (37%)
		zf-H2C2_2	684..709	CDD:290200	10/24 (42%)
		C2H2 Zn finger	700..720	CDD:275368	7/19 (37%)
		C2H2 Zn finger	728..748	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142319
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930