DRSC/TRiP Functional Genomics Resources

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Protein Alignment mld and ZNF99

DIOPT Version :9

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:NP_001073878.2 Gene:ZNF99 / 7652 HGNCID:13175 Length:864 Species:Homo sapiens


Alignment Length:676 Identity:147/676 - (21%)
Similarity:246/676 - (36%) Gaps:143/676 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  1341 ATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAG 1405
            |.:||:..|...:.....:|  .||..|  |..|::|....:|.| :|....|:.|..|..||  
Human   237 AFNISSMFTKCKIIHTGKKP--CKCEEC--GKVFNNSSTLMKHKI-IHTGKKPYKCEECGKAF-- 294

  Fly  1406 RTKRSQHILSHHVV----QQYQCGQCSHVFPAQKALDVHIQRFHMTLKT----------DPSGAV 1456
              |:|.|:..|..:    :.|:|.:|...|....||..| |..|...|.          ..|..:
Human   295 --KQSSHLTRHKAIHTGEKPYKCEECGKAFNHFSALRKH-QIIHTGKKPYKCEECGKAFSQSSTL 356

  Fly  1457 KVEDVQLQITSERRPR-----GRPYKPRLQLQQHQL-----QP------------QQKLQVQQ-- 1497
            :..::   |.:|.:|.     |:.:.....|::|::     :|            ..||.|.:  
Human   357 RKHEI---IHTEEKPYKYEECGKAFSNLSALRKHEIIHTGQKPYKCEECGKAFKWSSKLTVHKVI 418

  Fly  1498 HQQQQ--------KALQQLPQAQHHQ---QQQQPQLQQE---------VLQQVQQLQVQVQPQQH 1542
            |..::        ||.::....:.|:   ..:||...:|         .|::.:.:....:|.:.
Human   419 HTAEKPCKCEECGKAFKRFSALRKHKIIHTGKQPYKCEECSKAFSNFSALRKHEIIHTGEKPYKC 483

  Fly  1543 QQ-------------HQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSG 1594
            ::             |:.:...::|.:.........|.|.:.......|.:|...|.:|      
Human   484 EECGKAFKWSSKLTVHKVIHMEEKPCKCEECGKAFKHFSALRKHKIIHTGKKPYKCEEC------ 542

  Fly  1595 HSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITM-------PSPEQSEP--DSTT 1650
                .:.|....||.....:.|...........:....|.|:|.       ..|.:.|.  .:..
Human   543 ----GKAFNNSSTLMKHKIIHTGKKPYKCEECGKAFKQSSHLTRHKAIHTGEKPYKCEECGKAFN 603

  Fly  1651 TLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQ 1715
            .....||..:|...:.|........:.|.||:.....:.|         ....|..........:
Human   604 HFSALRKHQIIHTGKKPYKCEECGKAFSQSSTLRKHEIIH---------TGEKPYKCEECGKAFK 659

  Fly  1716 VSELRTSHHCLYCEER----------FTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALH 1770
            .|...|.|..::.||:          |.:..:|:||..:..|   ..||.|..|.:.:...:.|.
Human   660 WSSHLTRHKVIHTEEKPYKCEECGKAFNHFSALRKHKIIHTG---KKPYKCEECGKAFSQSSTLR 721

  Fly  1771 RHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH- 1834
            :|...|..| :||:|..|...|...|:||:||: :|...||..|:||||.|...|||:.|...| 
Human   722 KHEIIHTGE-KPYKCEECGKAFKWSSKLTVHKV-IHTAEKPCKCEECGKAFKHFSALRKHKIIHT 784

  Fly  1835 GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNED 1898
            |:..|:|:.|.:.|.....||||...|: |..|||:.|..:|...:....|...|:         
Human   785 GKKPYKCEECGKAFNNSSTLRKHEIIHTGEKSYKCEECGKAFQWSSKLTLHKVIHM--------- 840

  Fly  1899 AASKSPSNNNSHASSDKLENPATPIE 1924
              .::|:|..:.|   ||.|.:.|:|
Human   841 --ERNPANVKNVA---KLLNISQPLE 861

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
C2H2 Zn finger 1365..1388 CDD:275368 7/22 (32%)
C2H2 Zn finger 1396..1416 CDD:275368 7/19 (37%)
C2H2 Zn finger 1424..1445 CDD:275368 7/20 (35%)
C2H2 Zn finger 1725..1746 CDD:275368 6/30 (20%)
C2H2 Zn finger 1756..1776 CDD:275368 4/19 (21%)
C2H2 Zn finger 1785..1806 CDD:275368 8/20 (40%)
C2H2 Zn finger 1814..1834 CDD:275368 10/19 (53%)
zf-C2H2 1839..1861 CDD:278523 8/21 (38%)
C2H2 Zn finger 1841..1861 CDD:275368 7/19 (37%)
C2H2 Zn finger 1868..1888 CDD:275368 4/19 (21%)
ZNF99NP_001073878.2 KRAB 4..64 CDD:214630
KRAB 4..43 CDD:279668
C2H2 Zn finger 147..167 CDD:275368
C2H2 Zn finger 175..195 CDD:275368
C2H2 Zn finger 203..223 CDD:275368
C2H2 Zn finger 232..251 CDD:275368 4/13 (31%)
C2H2 Zn finger 259..279 CDD:275368 7/22 (32%)
COG5048 267..684 CDD:227381 74/444 (17%)
zf-H2C2_2 272..296 CDD:290200 8/28 (29%)
C2H2 Zn finger 287..307 CDD:275368 8/23 (35%)
zf-H2C2_2 299..324 CDD:290200 6/24 (25%)
C2H2 Zn finger 315..335 CDD:275368 7/20 (35%)
zf-H2C2_2 327..352 CDD:290200 6/25 (24%)
C2H2 Zn finger 343..363 CDD:275368 1/22 (5%)
C2H2 Zn finger 371..391 CDD:275368 3/19 (16%)
zf-H2C2_2 383..407 CDD:290200 3/23 (13%)
C2H2 Zn finger 399..419 CDD:275368 3/19 (16%)
C2H2 Zn finger 427..447 CDD:275368 3/19 (16%)
C2H2 Zn finger 455..475 CDD:275368 2/19 (11%)
zf-H2C2_2 467..491 CDD:290200 2/23 (9%)
C2H2 Zn finger 483..503 CDD:275368 1/19 (5%)
C2H2 Zn finger 511..531 CDD:275368 2/19 (11%)
zf-H2C2_2 523..548 CDD:290200 5/34 (15%)
COG5048 534..857 CDD:227381 87/360 (24%)
C2H2 Zn finger 539..559 CDD:275368 5/29 (17%)
zf-H2C2_2 552..576 CDD:290200 2/23 (9%)
C2H2 Zn finger 567..587 CDD:275368 3/19 (16%)
zf-H2C2_2 579..604 CDD:290200 4/24 (17%)
C2H2 Zn finger 595..615 CDD:275368 3/19 (16%)
zf-H2C2_2 607..632 CDD:290200 4/24 (17%)
C2H2 Zn finger 623..643 CDD:275368 3/19 (16%)
zf-H2C2_2 636..659 CDD:290200 2/31 (6%)
C2H2 Zn finger 651..671 CDD:275368 3/19 (16%)
zf-H2C2_2 663..688 CDD:290200 5/24 (21%)
C2H2 Zn finger 679..699 CDD:275368 4/19 (21%)
zf-H2C2_2 691..716 CDD:290200 8/27 (30%)
C2H2 Zn finger 707..727 CDD:275368 4/19 (21%)
zf-H2C2_2 720..743 CDD:290200 8/23 (35%)
C2H2 Zn finger 735..755 CDD:275368 8/20 (40%)
C2H2 Zn finger 763..783 CDD:275368 10/19 (53%)
zf-H2C2_2 775..800 CDD:290200 9/24 (38%)
C2H2 Zn finger 791..811 CDD:275368 7/19 (37%)
C2H2 Zn finger 819..839 CDD:275368 4/19 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142215
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24376
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.030

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