DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and ZNF91

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_003421.2	Gene:	ZNF91 / 7644	HGNCID:	13166	Length:	1191	Species:	Homo sapiens

Alignment Length:	588	Identity:	127/588 - (21%)
Similarity:	213/588 - (36%)	Gaps:	145/588 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1364 KCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCS 1428
            ||:.|  |..||:|...:.|.| .|....|:.|..|..||...:..::|.:.|...:.|:|.:|.
Human   351 KCKEC--GKAFSNSSTLANHKI-THTEEKPYKCKECDKAFKRLSTLTKHKIIHAGEKLYKCEECG 412

  Fly  1429 HVFPAQKALDVH--IQRFHMTLKTDPSGAVKVEDVQLQITSERR--PRGRPYK----PRLQLQQH 1485
            ..|.....|.:|  |.......|.:..|  |..:....:|..:|  .|.:|:|    .:..:...
Human   413 KAFNRSSNLTIHKFIHTGEKPYKCEECG--KAFNWSSSLTKHKRFHTREKPFKCKECGKAFIWSS 475

  Fly  1486 QLQPQQKLQVQQH----QQQQKALQQLPQAQHHQ---QQQQPQLQQEVLQQVQQLQVQVQPQQHQ 1543
            .|...:::...:.    ::..||.:|......|:   ..::|...:|..:..:|....      .
Human   476 TLTRHKRIHTGEKPYKCEECGKAFRQSSTLTKHKIIHTGEKPYKFEECGKAFRQSLTL------N 534

  Fly  1544 QHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCP----DCEDCTSGHSHANEQFEE 1604
            :|:.:...::|.       :.........|.|..|..||:...    .||:|....:|::.
Human   535 KHKIIHSREKPY-------KCKECGKAFKQFSTLTTHKIIHAGKKLYKCEECGKAFNHSSS---- 588

  Fly  1605 LQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDS--------TTTLRQYRKRGVI 1661
                                       .|.|..:.:.|:|....        ::|||::::
Human   589 ---------------------------LSTHKIIHTGEKSYKCEECGKAFLWSSTLRRHKR---- 622

  Fly  1662 VGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCL 1726
                  :|                            |...|                    :.|.
Human   623 ------IH----------------------------TGEKP--------------------YKCE 633

  Fly  1727 YCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVR 1791
            .|.:.|::..:|.||.::..|   ..||.|..|.:.:...:.|..|..:| .|.:||:|..|...
Human   634 ECGKAFSHSSALAKHKRIHTG---EKPYKCKECGKAFSNSSTLANHKITH-TEEKPYKCKECDKT 694

  Fly  1792 FPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELR 1855
            |.|.|.||.||| :|...|.:.|:||||.|...|.|..|...| ||..|:|:.|.:.|.:...|.
Human   695 FKRLSTLTKHKI-IHAGEKLYKCEECGKAFNRSSNLTIHKFIHTGEKPYKCEECGKAFNWSSSLT 758

  Fly  1856 KHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNED---AASKSPSNNNSHASSDKL 1916
            ||:|.|: |..:|||.|..:|:..:....|.:.|.....::.|:   |.|:| |....|.:....
Human   759 KHKRIHTREKPFKCKECGKAFIWSSTLTRHKRIHTGEKPYKCEECGKAFSRS-STLTKHKTIHTG 822

  Fly  1917 ENP 1919
            |.|
Human   823 EKP 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	10/20 (50%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
ZNF91	NP_003421.2	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	155..176	CDD:275368
		C2H2 Zn finger	212..232	CDD:275368
		COG5048	<220..370	CDD:227381	8/20 (40%)
		C2H2 Zn finger	240..260	CDD:275368
		C2H2 Zn finger	268..288	CDD:275368
		zf-H2C2_2	281..305	CDD:290200
		C2H2 Zn finger	296..316	CDD:275368
		zf-H2C2_2	309..333	CDD:290200
		COG5048	320..708	CDD:227381	88/468 (19%)
		C2H2 Zn finger	324..344	CDD:275368
		zf-H2C2_2	337..361	CDD:290200	5/11 (45%)
		C2H2 Zn finger	352..372	CDD:275368	8/22 (36%)
		zf-H2C2_2	365..389	CDD:290200	8/24 (33%)
		C2H2 Zn finger	380..400	CDD:275368	5/19 (26%)
		C2H2 Zn finger	408..428	CDD:275368	5/19 (26%)
		C2H2 Zn finger	436..456	CDD:275368	4/21 (19%)
		zf-H2C2_2	448..471	CDD:290200	5/22 (23%)
		C2H2 Zn finger	464..484	CDD:275368	1/19 (5%)
		zf-H2C2_2	477..501	CDD:290200	3/23 (13%)
		C2H2 Zn finger	492..512	CDD:275368	4/19 (21%)
		C2H2 Zn finger	520..540	CDD:275368	3/25 (12%)
		zf-H2C2_2	533..557	CDD:290200	2/36 (6%)
		C2H2 Zn finger	548..568	CDD:275368	5/19 (26%)
		C2H2 Zn finger	576..596	CDD:275368	6/50 (12%)
		C2H2 Zn finger	604..624	CDD:275368	3/29 (10%)
		zf-H2C2_2	617..641	CDD:290200	8/81 (10%)
		COG5048	628..1069	CDD:227381	67/224 (30%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		zf-H2C2_2	644..669	CDD:290200	8/27 (30%)
		C2H2 Zn finger	660..680	CDD:275368	4/19 (21%)
		C2H2 Zn finger	688..708	CDD:275368	10/20 (50%)
		C2H2 Zn finger	716..736	CDD:275368	9/19 (47%)
		C2H2 Zn finger	744..764	CDD:275368	7/19 (37%)
		zf-H2C2_2	756..779	CDD:290200	10/22 (45%)
		C2H2 Zn finger	772..792	CDD:275368	5/19 (26%)
		zf-H2C2_2	785..809	CDD:290200	4/23 (17%)
		C2H2 Zn finger	800..820	CDD:275368	6/20 (30%)
		zf-H2C2_2	813..837	CDD:290200	3/13 (23%)
		C2H2 Zn finger	828..848	CDD:275368
		C2H2 Zn finger	856..876	CDD:275368
		C2H2 Zn finger	885..904	CDD:275368
		C2H2 Zn finger	912..932	CDD:275368
		zf-H2C2_2	924..949	CDD:290200
		C2H2 Zn finger	940..960	CDD:275368
		C2H2 Zn finger	968..988	CDD:275368
		zf-H2C2_2	981..1005	CDD:290200
		C2H2 Zn finger	996..1016	CDD:275368
		zf-H2C2_2	1009..1033	CDD:290200
		C2H2 Zn finger	1024..1044	CDD:275368
		C2H2 Zn finger	1052..1072	CDD:275368
		C2H2 Zn finger	1080..1100	CDD:275368
		zf-H2C2_2	1093..1116	CDD:290200
		C2H2 Zn finger	1108..1128	CDD:275368
		zf-H2C2_2	1120..1145	CDD:290200
		C2H2 Zn finger	1136..1156	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100