DRSC/TRiP Functional Genomics Resources

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Protein Alignment mld and ZNF84

DIOPT Version :10

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:NP_003419.3 Gene:ZNF84 / 7637 HGNCID:13159 Length:738 Species:Homo sapiens


Alignment Length:609 Identity:133/609 - (21%)
Similarity:214/609 - (35%) Gaps:167/609 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  1364 KCRFCHNGPRFSS--SL--EYSRHIIDL-----------------------HPAVAPFNCPHCPM 1401
            :|..|..  |||.  ||  ..||||.|:                       |....|:||..|..
Human   208 ECSECRK--RFSKKPSLIKHQSRHIRDIAFGCGNCGKTFPQKSQFITHHRTHTGEKPYNCSQCGK 270

  Fly  1402 AFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLK-----------TDPSGA 1455
            ||:.:::.:.|..:|...:.|:||:|...|..:..|..| .|.|...|           ::.|..
Human   271 AFSQKSQLTSHQRTHTGEKPYECGECGKAFSRKSHLISH-WRTHTGEKPYGCNECGRAFSEKSNL 334

  Fly  1456 VKVEDVQLQITSER----RPRGRPYKPRLQLQQHQ-----LQP----------QQKLQVQQHQ-- 1499
            :..:.:.   |.|:    |..|:.:..:.||..|.     .:|          .:|.::.:||  
Human   335 INHQRIH---TGEKPFECRECGKAFSRKSQLVTHHRTHTGTKPFGCSDCRKAFFEKSELIRHQTI 396

  Fly  1500 ----------QQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQP 1554
                      :.:||.::.....:||:....:.....:|..:...   |......||.....::|
Human   397 HTGEKPYECSECRKAFRERSSLINHQRTHTGEKPHGCIQCGKAFS---QKSHLISHQMTHTGEKP 458

  Fly  1555 -----------QQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTL 1608
                       ::..|::.|..|           |..|...|.:|          .:.|.|..:|
Human   459 FICSKCGKAFSRKSQLVRHQRTH-----------TGEKPYECSEC----------GKAFSEKLSL 502

  Fly  1609 QAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYR--KRGVIVGPQGPLHLA 1671
            .....:.|.....|.....:......|:.      |...:.|..:.|.  :.|...|.:      
Human   503 TNHQRIHTGEKPYVCSECGKAFCQKSHLI------SHQRTHTGEKPYECSECGKAFGEK------ 555

  Fly  1672 TPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEI 1736
                         ||...|     ..|.....|                  :.|..||:.|:.:.
Human   556 -------------SSLATH-----QRTHTGEKP------------------YECRDCEKAFSQKS 584

  Fly  1737 SLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLH 1801
            .|..|.::..|   ..||.|::|::.:..::.|.||:.:|..| :|||||.||..|...|.|..|
Human   585 QLNTHQRIHTG---EKPYECSLCRKAFFEKSELIRHLRTHTGE-KPYECNECRKAFREKSSLINH 645

  Fly  1802 KITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EM 1864
            : .:|...||..|.||||.|..:|.|..|.:.| ||..|.|..|.:.|....:|..|:|.|: |.
Human   646 Q-RIHTGEKPFECSECGKAFSRKSHLIPHQRTHTGEKPYGCSECRKAFSQKSQLVNHQRIHTGEK 709

  Fly  1865 FYKCKFCPSSFMRFTNFRAHMKTH 1888
            .|:|..|..:|.:.:....|.:||
Human   710 PYRCIECGKAFSQKSQLINHQRTH 733

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
PAT1 <959..>1109 CDD:401645
C2H2 Zn finger 1365..1388 CDD:275368 12/49 (24%)
C2H2 Zn finger 1396..1416 CDD:275368 5/19 (26%)
C2H2 Zn finger 1424..1445 CDD:275368 7/20 (35%)
C2H2 Zn finger 1725..1746 CDD:275368 6/20 (30%)
C2H2 Zn finger 1756..1776 CDD:275368 5/19 (26%)
C2H2 Zn finger 1785..1806 CDD:275368 8/20 (40%)
zf-C2H2 1812..1834 CDD:395048 9/21 (43%)
C2H2 Zn finger 1814..1834 CDD:275368 9/19 (47%)
zf-C2H2 1839..1861 CDD:395048 7/21 (33%)
C2H2 Zn finger 1841..1861 CDD:275368 6/19 (32%)
zf-C2H2 1866..1888 CDD:395048 5/21 (24%)
C2H2 Zn finger 1868..1888 CDD:275368 4/19 (21%)
ZNF84NP_003419.3 KRAB 9..68 CDD:214630
C2H2 Zn finger 209..229 CDD:275368 8/21 (38%)
C2H2 Zn finger 237..257 CDD:275368 0/19 (0%)
zf-C2H2 263..285 CDD:395048 6/21 (29%)
C2H2 Zn finger 265..285 CDD:275368 5/19 (26%)
zf-H2C2_2 278..302 CDD:463886 7/23 (30%)
C2H2 Zn finger 293..313 CDD:275368 7/20 (35%)
COG5048 317..724 CDD:227381 100/486 (21%)
C2H2 Zn finger 321..341 CDD:275368 1/19 (5%)
C2H2 Zn finger 349..369 CDD:275368 5/19 (26%)
C2H2 Zn finger 377..397 CDD:275368 3/19 (16%)
C2H2 Zn finger 405..425 CDD:275368 4/19 (21%)
C2H2 Zn finger 433..453 CDD:275368 4/22 (18%)
C2H2 Zn finger 461..481 CDD:275368 2/19 (11%)
C2H2 Zn finger 489..509 CDD:275368 5/29 (17%)
C2H2 Zn finger 517..537 CDD:275368 2/25 (8%)
C2H2 Zn finger 545..565 CDD:275368 5/43 (12%)
C2H2 Zn finger 573..593 CDD:275368 6/19 (32%)
C2H2 Zn finger 601..621 CDD:275368 5/19 (26%)
C2H2 Zn finger 629..649 CDD:275368 8/20 (40%)
C2H2 Zn finger 657..677 CDD:275368 9/19 (47%)
C2H2 Zn finger 685..705 CDD:275368 6/19 (32%)
C2H2 Zn finger 713..733 CDD:275368 4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

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