DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and ZNF33B

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001291962.1	Gene:	ZNF33B / 7582	HGNCID:	13097	Length:	785	Species:	Homo sapiens

Alignment Length:	985	Identity:	176/985 - (17%)
Similarity:	321/985 - (32%)	Gaps:	307/985 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1001 QNESANHSPFESPISSPQVQ---SQIELQ-MEPQIETQMQPQIETRMQHDVLSVQSPQN------ 1055
            :.||.....|:..:|...|.   :|.|.| ::|.         :..:..||: :::..|
Human     6 RRESEVDQKFQGSVSFKDVTVGFTQEEWQHLDPS---------QRALYRDVM-LENYSNLVSVGY 60

  Fly  1056 --HQPQV-----QSHDQSQMQHQIPPQIEPQI------EVQNQEQNTLQLVPQAQH--QVVPHVQ 1105
              |:|:|     |..:..:::.:.|.|..|::      :.::||.       |::|  :|   |.
Human    61 CAHKPEVIFRLEQGEEPWRLEEEFPSQSFPEVWTADHLKERSQEN-------QSKHLWEV---VF 115

  Fly  1106 LQSQLVPHVQTQGTTTTVTYEQIYQQHIVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQQ 1170
            :.::::  .:.||....:.:                  .|.|.|.||               ::.
Human   116 INNEML--TKEQGNVIGIPF------------------NMDVSSFPS---------------RKM 145

  Fly  1171 QVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVIEQVNHQQQH 1235
            ..|:.|.|    :....|..:..:...|....||.:             :....::..:.|.:.|
Human   146 FCQYDSRG----MSFNTVSELVISKINYLGKKSDEF-------------NACGKLLLNIKHDETH 193

  Fly  1236 CQQQIQMSQQQHQRQHQQQQAQQQQQPIM------ILIQQPEIQQPVASASNPQQA--------- 1285
            .:::.::.:.::...|::...|.::...:      .:.|:..:::.|.:....:.|
Human   194 TREKNEVLKNRNTLSHRENTLQHEKIQTLDHNFEYSICQETLLEKAVFNTRKRENAEENNCDYNE 258

  Fly  1286 ---------PLHIYNAATSNDVHQMQHTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMP-- 1339
                     .|..:....|.|.|             |:....::....:.|  :..|.  |:|
Human   259 FGRTFCDSSSLLFHQIPPSKDSH-------------YEFSDCEKFLCVKST--LSKHD--GVPVK 306

  Fly  1340 ------GATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPH 1398
                  ...:...|:....:..........:|..|  |..|......:|| ..:|.....|.|..
Human   307 HYDCGESGNNFRRKLCLSQLQKGDKGEKHFECNEC--GKAFWEKSHLTRH-QRVHTGEKHFQCNQ 368

  Fly  1399 CPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQL 1463
            |...|..::..::|..||...:.::|.:|...|..:.||.:| ||.|...|.....|.
Human   369 CGKTFWEKSNLTKHQRSHTGEKPFECNECGKAFSHKSALTLH-QRTHTGEKPYQCNAC------- 425

  Fly  1464 QITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQ--------KALQQLPQAQHHQQQQQP 1520
                     |:.:..:..|.:||         :.|..|:        |:.........||:....
Human   426 ---------GKTFYQKSDLTKHQ---------RTHTGQKPYECYECGKSFCMNSHLTVHQRTHTG 472

  Fly  1521 QLQQEVLQQVQQLQVQVQPQQHQQ------------------HQQVLQVQQPQQQPLMQPQSPH- 1566
            :...|.|:..:....:....|||:                  |:.||    .:.|.:.....|:
Human   473 EKPFECLECGKSFCQKSHLTQHQRTHIGDKPYECNACGKTFYHKSVL----TRHQIIHTGLKPYE 533

  Fly  1567 ----------PSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTI 1621
                      .|.:.:.....|..|...||:|          .:.|....||
Human   534 CYECGKTFCLKSDLTIHQRTHTGEKPFACPEC----------GKFFSHKSTL------------- 575

  Fly  1622 VSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSS 1686
                       |||....:.|:...........|.|                           |.
Human   576 -----------SQHYRTHTGEKPYECHECGKIFYNK---------------------------SY 602

  Fly  1687 TVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTT 1751
            ...|....:...|                       :.|..|.:.|..:..|.:|.::..|   .
Human   603 LTKHNRTHTGEKP-----------------------YECNECGKTFCQKSQLTQHQRIHIG---E 641

  Fly  1752 MPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDE 1816
            .||.|..|.:.:..::||..|..:|..| :||:||.|...|...|.|.||: ..|...||:.|:|
Human   642 KPYECNECGKAFCHKSALIVHQRTHTQE-KPYKCNECGKSFCVKSGLILHE-RKHTGEKPYECNE 704

  Fly  1817 CGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFT 1879
            |||.|..:|:|..|.:.| ||...||:.|.:.|....:|.||:|:|: |..|:|..|..:|.:.:
Human   705 CGKSFSHKSSLTVHHRAHTGEKSCQCNECGKIFYRKSDLAKHQRSHTGEKPYECNTCRKTFSQKS 769

  Fly  1880 NFRAHMKTHL 1889
            |...|.:||:
Human   770 NLIVHQRTHI 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1424..1445	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
ZNF33B	NP_001291962.1	KRAB	19..78	CDD:214630	13/68 (19%)
		KRAB	19..58	CDD:279668	9/48 (19%)
		C2H2 Zn finger	310..330	CDD:275368	1/19 (5%)
		COG5048	336..681	CDD:227381	82/465 (18%)
		C2H2 Zn finger	338..358	CDD:275368	6/22 (27%)
		zf-H2C2_2	350..374	CDD:290200	6/24 (25%)
		C2H2 Zn finger	366..386	CDD:275368	4/19 (21%)
		zf-H2C2_2	378..403	CDD:290200	6/24 (25%)
		C2H2 Zn finger	394..414	CDD:275368	8/20 (40%)
		zf-H2C2_2	406..429	CDD:290200	9/39 (23%)
		C2H2 Zn finger	422..442	CDD:275368	5/44 (11%)
		zf-H2C2_2	434..457	CDD:290200	6/31 (19%)
		C2H2 Zn finger	450..470	CDD:275368	3/19 (16%)
		zf-H2C2_2	462..485	CDD:290200	4/22 (18%)
		zf-C2H2	476..498	CDD:278523	5/21 (24%)
		C2H2 Zn finger	478..498	CDD:275368	4/19 (21%)
		C2H2 Zn finger	506..526	CDD:275368	4/23 (17%)
		C2H2 Zn finger	534..554	CDD:275368	1/19 (5%)
		zf-H2C2_2	546..571	CDD:290200	6/34 (18%)
		C2H2 Zn finger	562..582	CDD:275368	9/53 (17%)
		zf-H2C2_2	575..597	CDD:290200	5/45 (11%)
		C2H2 Zn finger	590..610	CDD:275368	4/46 (9%)
		zf-H2C2_2	602..625	CDD:290200	4/45 (9%)
		C2H2 Zn finger	618..638	CDD:275368	5/19 (26%)
		zf-H2C2_2	631..653	CDD:290200	7/24 (29%)
		C2H2 Zn finger	646..666	CDD:275368	5/19 (26%)
		zf-H2C2_2	658..681	CDD:290200	10/23 (43%)
		COG5048	668..>727	CDD:227381	26/60 (43%)
		C2H2 Zn finger	674..694	CDD:275368	8/20 (40%)
		zf-H2C2_2	690..711	CDD:290200	10/21 (48%)
		C2H2 Zn finger	702..722	CDD:275368	9/19 (47%)
		C2H2 Zn finger	730..750	CDD:275368	7/19 (37%)
		zf-H2C2_2	742..767	CDD:290200	10/24 (42%)
		C2H2 Zn finger	758..778	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100