DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and ZNF33A

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001265106.1	Gene:	ZNF33A / 7581	HGNCID:	13096	Length:	832	Species:	Homo sapiens

Alignment Length:	1021	Identity:	189/1021 - (18%)
Similarity:	322/1021 - (31%)	Gaps:	300/1021 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1035 MQPQIETRMQHDVLSV--QSPQNHQPQVQSHD-----------QSQMQHQIPPQIEPQIEVQNQE 1086
            |||.........|:||  ::.||.|.|.....           |.:.||..|.|.....:|..:.
Human     1 MQPDEGVGCIFRVVSVFPRTEQNEQEQKSQESVSFKDVTVGFTQEEWQHLDPSQRALYRDVMLEN 65

  Fly  1087 QNTLQLVPQAQHQVVPHV---------------QLQSQLVPHVQTQGTTTTVTYEQIYQQHIVQQ 1136
            .:.|..|....|:  |.|               :..||..|.|.|             ..|:.::
Human    66 YSNLVSVGYCVHK--PEVIFRLQQGEEPWKQEEEFPSQSFPEVWT-------------ADHLKER 115

  Fly  1137 TVQQSS----------NKM------QVISLP---SAGSETTRQWQTQQSQQQQQVQWSSVGGLEA 1182
            :.:..|          |:|      .||.:|   ...|..:|         :...|..|.|
Human   116 SQENQSKHLWEVVFINNEMLTKEQGDVIGIPFNVDVSSFPSR---------KMFCQCDSCG---- 167

  Fly  1183 IKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVIEQVNHQQQHCQQQIQMSQQQH 1247
            :....|..:..:...|....||.:             :....::..:.|.:.|.|::.::.:.::
Human   168 MSFNTVSELVISKINYLGKKSDEF-------------NACGKLLLNIKHDETHTQEKNEVLKNRN 219

  Fly  1248 QRQHQQQQAQQQQQPIM------ILIQQPEIQQPVASASNPQQA------------------PLH 1288
            ...|.::..|.::...:      .:.|:..:::.|.:....:.|                  .|.
Human   220 TLSHHEETLQHEKIQTLEHNFEYSICQETLLEKAVFNTQKRENAEENNCDYNEFGRTLCDSSSLL 284

  Fly  1289 IYNAATSNDVHQMQHTQRQQIRQQYQHQQYQR-------LQQPQQTRVVQSHPVLGMPGATSIST 1346
            .:..:.|.|.|             |:....::       |.:|.  .|...|...|..| .:...
Human   285 FHQISPSRDNH-------------YEFSDCEKFLCVKSTLSKPH--GVSMKHYDCGESG-NNFRR 333

  Fly  1347 KVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQ 1411
            |:....:..........:|..|  |..|......:|| ..:|....||.|..|..||..::..::
Human   334 KLCLSHLQKGDKGEKHFECNEC--GKAFWEKSHLTRH-QRVHTGQKPFQCNECEKAFWDKSNLTK 395

  Fly  1412 HILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPY 1476
            |..||...:.::|.:|...|..:.||.:| ||.|...|.....|.                |:.:
Human   396 HQRSHTGEKPFECNECGKAFSHKSALTLH-QRTHTGEKPYQCNAC----------------GKTF 443

  Fly  1477 KPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQ 1541
            ..:..|.:|| :....|:..:..:..|:.:.....:.||:....:...|.|:..:....:....|
Human   444 CQKSDLTKHQ-RTHTGLKPYECYECGKSFRVTSHLKVHQRTHTGEKPFECLECGKSFSEKSNLTQ 507

  Fly  1542 HQQ------------------HQQVLQVQQPQQQPLMQPQSPH-----------PSTVEMQASPT 1577
            ||:                  |:.:|    .:.|.:.....|:           .|.:.:.....
Human   508 HQRIHIGDKSYECNACGKTFYHKSLL----TRHQIIHTGWKPYECYECGKTFCLKSDLTVHQRTH 568

  Fly  1578 TPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPE 1642
            |.:|...||:|          .:.|....||                        |||....:.|
Human   569 TGQKPFACPEC----------GKFFSHKSTL------------------------SQHYRTHTGE 599

  Fly  1643 QSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPS 1707
            :...........|.|                           |....|....:...|
Human   600 KPYECHECGKIFYNK---------------------------SYLTKHNRTHTGEKP-------- 629

  Fly  1708 PAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRH 1772
                           :.|..|.:.|..:..|.:|.::..|   ..||.|..|.:.:..::||..|
Human   630 ---------------YECNECGKAFYQKSQLTQHQRIHIG---EKPYKCNECGKAFCHKSALIVH 676

  Fly  1773 MESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GE 1836
            ..:|..| :||:||.|...|...|.|..|: ..|...||:.|:||||.|..:|:|..|.:.| ||
Human   677 QRTHTQE-KPYKCNECGKSFCVKSGLIFHE-RKHTGEKPYECNECGKFFRHKSSLTVHHRAHTGE 739

  Fly  1837 LGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDAA 1900
            ...||:.|.:.|....||.:|:|:|: |..|:|..|..:|.:.:|...|.:.|:...:....|..
Human   740 KSCQCNECGKIFYRKSELAQHQRSHTGEKPYECNTCRKTFSQKSNLIVHQRRHIGENLMNEMDIR 804

  Fly  1901 SKSPSNNNSHASSDKLENPATPIEETPLTPMSSGGHLYHSPDEYPN 1946
            :..|                    :..|...|...|...|||:..|
Human   805 NFQP--------------------QVSLHNASEYSHCGESPDDILN 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
ZNF33A	NP_001265106.1	KRAB	33..92	CDD:214630	11/60 (18%)
		KRAB	33..72	CDD:279668	7/38 (18%)
		COG5048	163..537	CDD:227381	68/431 (16%)
		C2H2 Zn finger	324..344	CDD:275368	3/20 (15%)
		C2H2 Zn finger	352..372	CDD:275368	6/22 (27%)
		zf-H2C2_2	364..388	CDD:290200	8/24 (33%)
		C2H2 Zn finger	380..400	CDD:275368	5/19 (26%)
		zf-H2C2_2	392..417	CDD:290200	6/24 (25%)
		C2H2 Zn finger	408..428	CDD:275368	8/20 (40%)
		zf-H2C2_2	420..443	CDD:290200	9/39 (23%)
		C2H2 Zn finger	436..456	CDD:275368	5/36 (14%)
		COG5048	444..820	CDD:227381	94/489 (19%)
		zf-H2C2_2	448..471	CDD:290200	5/23 (22%)
		C2H2 Zn finger	464..484	CDD:275368	3/19 (16%)
		zf-H2C2_2	476..500	CDD:290200	4/23 (17%)
		C2H2 Zn finger	492..512	CDD:275368	4/19 (21%)
		C2H2 Zn finger	520..540	CDD:275368	3/23 (13%)
		C2H2 Zn finger	548..568	CDD:275368	1/19 (5%)
		zf-H2C2_2	560..585	CDD:290200	6/34 (18%)
		C2H2 Zn finger	576..596	CDD:275368	9/53 (17%)
		zf-H2C2_2	589..611	CDD:290200	5/45 (11%)
		C2H2 Zn finger	604..624	CDD:275368	4/46 (9%)
		zf-H2C2_2	616..639	CDD:290200	4/45 (9%)
		C2H2 Zn finger	632..652	CDD:275368	5/19 (26%)
		zf-H2C2_2	645..667	CDD:290200	7/24 (29%)
		C2H2 Zn finger	660..680	CDD:275368	5/19 (26%)
		zf-H2C2_2	672..695	CDD:290200	10/23 (43%)
		C2H2 Zn finger	688..708	CDD:275368	7/20 (35%)
		C2H2 Zn finger	716..736	CDD:275368	9/19 (47%)
		C2H2 Zn finger	744..764	CDD:275368	7/19 (37%)
		zf-H2C2_2	756..781	CDD:290200	10/24 (42%)
		C2H2 Zn finger	772..792	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100