DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp74

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_848471.2	Gene:	Zfp74 / 72723	MGIID:	107784	Length:	679	Species:	Mus musculus

Alignment Length:	766	Identity:	156/766 - (20%)
Similarity:	247/766 - (32%)	Gaps:	234/766 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1179 GLEAIKSAPVE-------SVAPTTTTYYISASDLYPQQTETYTML---QPASNESYVIEQVNHQQ 1233
            ||...|...::       .:.||....|.:.      ..|.|..|   .|...:..||.::..::
Mouse     6 GLVTFKDVAIDFTQEEWKQLDPTQRNLYRNV------MLENYNNLITVGPPLTKPEVIFKLEQEE 64

  Fly  1234 QHCQQQIQM------SQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYNA 1292
            :.|..:.::      .:.....:||:.|..|..:.|::..:..|..:..||...|        ||
Mouse    65 EPCVVEREVLWRPCPGEILGIDEHQKIQDGQVFEGIVVTSEASECPEEFASTFFP--------NA 121

  Fly  1293 ATSNDVHQM----------------QHTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGA 1341
            .:...:|.:                ...|.....:|:   :|....||..|.  ..|.||
Mouse   122 DSIPSMHSLFECDGVGECLEPNFGDDDVQYPLPEEQF---EYDDAMQPFHTS--SPHFVL----- 176

  Fly  1342 TSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGR 1406
                   ||            .||..|..|  ||.:|:..|| :.:|.....:.|..|...|:.:
Mouse   177 -------TP------------FKCNHCGKG--FSQTLDLIRH-LRVHTGGKLYECHQCGKGFSHK 219

  Fly  1407 TKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRP 1471
            .|...|...|...|.|:|.:|...|.....|..| ||.|                    |.|
Mouse   220 EKLINHHKLHSREQCYECSECGKTFIKMSNLIRH-QRIH--------------------TGE--- 260

  Fly  1472 RGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQ---QQQPQLQQEVLQQVQQL 1533
              :||                    ..|:..|:..|......|::   .::|....|..:...|.
Mouse   261 --KPY--------------------VCQECGKSFGQKSNLIDHEKIHTGEKPYKCNECGKSFSQK 303

  Fly  1534 QVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHA 1598
            |..|      .||:|...::|..........|..:::.:.....|..|...|..|       ..|
Mouse   304 QSLV------AHQKVHTGEKPYACNECGKAFPRVASLALHMRGHTGEKPYKCDKC-------GKA 355

  Fly  1599 NEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVG 1663
            ..||..|               |:            |:.:.:.|          :.|.     .|
Mouse   356 FSQFSML---------------II------------HVRVHTGE----------KPYE-----CG 378

  Fly  1664 PQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTS------ 1722
            ..|            .:.|.||:...||...:...|              .:..|.|.|
Mouse   379 ECG------------KAFSQSSALTVHIRSHTGEKP--------------YECKECRKSFSHKKN 417

  Fly  1723 -------------HHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHME 1774
                         :.|..|.:.|....:|.:|.::..|   ..||:|..|.:.:..::.|..|.:
Mouse   418 FITHQKIHTREKPYGCNECGKAFIQMSNLVRHQRIHTG---EKPYLCKECGKAFSQKSNLIAHEK 479

  Fly  1775 SHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELG 1838
            .|..| :|||||.|...|.:......|: .||...||:.|::|||.|...::|..|::.| ||..
Mouse   480 IHSGE-KPYECNECGKAFSQKQNFITHQ-KVHTGEKPYDCNKCGKAFSQIASLTLHLRSHTGEKP 542

  Fly  1839 YQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            |:|:.|.:.|.....|..|.|:|: |..|.|..|..:|.:.|:...||:.|
Mouse   543 YECEKCGKAFSQCSLLNLHMRSHTGEKPYVCNECGKAFSQRTSLIVHMRGH 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1814..1834	CDD:275368	7/19 (37%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	6/19 (32%)
Zfp74	NP_848471.2	KRAB	8..68	CDD:214630	10/65 (15%)
		C2H2 Zn finger	181..201	CDD:275368	8/22 (36%)
		COG5048	205..638	CDD:227381	110/521 (21%)
		C2H2 Zn finger	209..229	CDD:275368	5/19 (26%)
		C2H2 Zn finger	237..257	CDD:275368	7/20 (35%)
		C2H2 Zn finger	265..285	CDD:275368	4/19 (21%)
		C2H2 Zn finger	293..313	CDD:275368	6/25 (24%)
		C2H2 Zn finger	321..341	CDD:275368	1/19 (5%)
		C2H2 Zn finger	349..369	CDD:275368	8/53 (15%)
		C2H2 Zn finger	377..397	CDD:275368	7/31 (23%)
		C2H2 Zn finger	405..425	CDD:275368	3/19 (16%)
		C2H2 Zn finger	433..453	CDD:275368	5/19 (26%)
		C2H2 Zn finger	461..481	CDD:275368	4/19 (21%)
		C2H2 Zn finger	489..509	CDD:275368	5/20 (25%)
		C2H2 Zn finger	517..537	CDD:275368	7/19 (37%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		C2H2 Zn finger	573..593	CDD:275368	6/19 (32%)
		C2H2 Zn finger	601..621	CDD:275368
		C2H2 Zn finger	629..649	CDD:275368
		zf-H2C2_2	641..666	CDD:372612
		C2H2 Zn finger	657..677	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832234
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930