DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp689

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_780372.2	Gene:	Zfp689 / 71131	MGIID:	1918381	Length:	500	Species:	Mus musculus

Alignment Length:	392	Identity:	99/392 - (25%)
Similarity:	144/392 - (36%)	Gaps:	73/392 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1537 VQPQQHQQ---HQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKI-------LCCPDCEDC 1591
            :.||::::   .|:..:.:|..::..:.|....|...:....|:.||.|       ..|||| .|
Mouse    93 LDPQEYRRWVTFQRKTRSKQKTEEKDVFPPKEAPRKGKRGRKPSKPRLIPRQTSGGPICPDC-GC 156

  Fly  1592 TSGHSHANEQFEELQTLQAP------------PTVLTPPSTIVSVPSP-----------QPMVYS 1633
            |.....|.|..:..|.|:.|            |::|.......|...|           |....|
Mouse   157 TFPDHLALESHKCAQNLKKPYPCPDCGRRFSYPSLLVSHRRAHSGECPYVCDQCGKRFSQRKNLS 221

  Fly  1634 QHITMPSPEQSE--PDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHI---PP 1693
            ||..:.:.|:..  ||.....|:                         |.|.::....|.   |.
Mouse   222 QHQVIHTGEKPYHCPDCGRCFRR-------------------------SRSLANHRTTHTGEKPH 261

  Fly  1694 ASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTI 1758
            ..|:.....|.|...|:.......|  ..:.||.|..||....:|..|.::..|   ..||.|..
Mouse   262 QCPSCGRRFAYPSLLAIHQRTHTGE--KPYTCLECSRRFRQRTALVIHQRIHTG---EKPYPCPD 321

  Fly  1759 CKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGT 1823
            |:|.:...:.|..|...|..| |||.|..|..||.:.|.|..|:: :|...||:.|.:||:.|..
Mouse   322 CERRFSSSSRLVSHRRVHSGE-RPYACENCEARFSQRSTLLQHQL-LHTGEKPYPCPDCGRAFRR 384

  Fly  1824 ESALKTHIKFHGELG-YQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMK 1886
            ..:|..|...|.|.. :.||.|.|.|.|...|..|||.|| |..|.|..|...|.::::...|..
Mouse   385 SGSLAIHRSTHTEEKLHACDDCGRRFAYPSLLASHRRVHSGERPYACDLCSKRFAQWSHLSQHQL 449

  Fly  1887 TH 1888
            .|
Mouse   450 LH 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368
		C2H2 Zn finger	1396..1416	CDD:275368
		C2H2 Zn finger	1424..1445	CDD:275368
		C2H2 Zn finger	1725..1746	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1814..1834	CDD:275368	6/19 (32%)
		zf-C2H2	1839..1861	CDD:278523	10/21 (48%)
		C2H2 Zn finger	1841..1861	CDD:275368	10/19 (53%)
		C2H2 Zn finger	1868..1888	CDD:275368	4/19 (21%)
Zfp689	NP_780372.2	KRAB	29..88	CDD:214630
		KRAB	29..68	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	105..144		8/38 (21%)
		C2H2 Zn finger	151..171	CDD:275368	8/20 (40%)
		COG5048	171..>466	CDD:227381	81/313 (26%)
		C2H2 Zn finger	179..199	CDD:275368	2/19 (11%)
		C2H2 Zn finger	207..227	CDD:275368	4/19 (21%)
		zf-H2C2_2	219..244	CDD:290200	6/24 (25%)
		C2H2 Zn finger	235..255	CDD:275368	5/44 (11%)
		zf-H2C2_2	247..272	CDD:290200	4/24 (17%)
		C2H2 Zn finger	263..283	CDD:275368	4/19 (21%)
		zf-H2C2_2	276..300	CDD:290200	7/25 (28%)
		C2H2 Zn finger	291..311	CDD:275368	7/19 (37%)
		zf-H2C2_2	303..328	CDD:290200	8/27 (30%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		zf-H2C2_2	332..356	CDD:290200	11/24 (46%)
		C2H2 Zn finger	347..367	CDD:275368	7/20 (35%)
		zf-H2C2_2	360..384	CDD:290200	9/24 (38%)
		C2H2 Zn finger	375..395	CDD:275368	6/19 (32%)
		C2H2 Zn finger	403..423	CDD:275368	10/19 (53%)
		zf-H2C2_2	416..440	CDD:290200	11/23 (48%)
		C2H2 Zn finger	431..451	CDD:275368	4/19 (21%)
		C2H2 Zn finger	459..475	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832261
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930