DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp770

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_006234777.1	Gene:	Zfp770 / 691610	RGDID:	1597283	Length:	699	Species:	Rattus norvegicus

Alignment Length:	301	Identity:	74/301 - (24%)
Similarity:	110/301 - (36%)	Gaps:	73/301 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1725 CLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICR 1789
            |..|.:.|.....|.:|:.:..|   ..|:.|..|.:.:|....|.||..:|::   |:.||||:
  Rat    27 CNICFKHFETPSKLARHYLIHTG---QKPFECDACHKNFRQLVHLERHQLTHNL---PFSCNICQ 85

  Fly  1790 VRFP------RPSQLTLHKITVH-------LL----SKP-------------------------- 1811
            ..|.      |..|  ||..:.|       ||    .||
  Rat    86 RHFKNLKTFVRHQQ--LHNESCHSDIKVRRLLETKQEKPVYGAYSAFTADERRALHPCSKSDPTY 148

  Fly  1812 ---------HTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMF 1865
                     |.|..|||.|.::|.|..|...| |:..::|..|.::|.....|:.|:.||| |..
  Rat   149 STTERRKNIHACTICGKMFPSQSKLDRHALIHTGQRPFKCVLCSKSFRQSTHLKIHQLTHSEERP 213

  Fly  1866 YKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDAASKSPSN----NNSHASSDKLE--NPATPIE 1924
            ::|.||...|...:....|.:.|.....|:|.....|||.:    |..:|..|..|  :.....|
  Rat   214 FQCCFCQKGFKIQSKLLKHKQIHTRNKTFQNLPLKVKSPESCPLPNKLNAKQDAFESGDMGESEE 278

  Fly  1925 ETPLTPMSSGGHLYHSPDEYPNSVESCAGNSVALESYATTP 1965
            :.||...|    :|..|.:. :..|.|..:...|..:...|
  Rat   279 KNPLDVHS----IYIVPFQC-SECEECFESEQILNGHKCLP 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368
		C2H2 Zn finger	1396..1416	CDD:275368
		C2H2 Zn finger	1424..1445	CDD:275368
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	9/26 (35%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	5/21 (24%)
		C2H2 Zn finger	1841..1861	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
Zfp770	XP_006234777.1	C2H2 Zn finger	27..47	CDD:275368	5/19 (26%)
		C2H2 Zn finger	55..75	CDD:275368	6/19 (32%)
		C2H2 Zn finger	81..101	CDD:275368	7/21 (33%)
		C2H2 Zn finger	160..180	CDD:275368	8/19 (42%)
		C2H2 Zn finger	188..208	CDD:275368	5/19 (26%)
		C2H2 Zn finger	216..236	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368
		C2H2 Zn finger	508..528	CDD:275368
		C2H2 Zn finger	635..655	CDD:275368
		C2H2 Zn finger	663..683	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100