DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp40

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_038947408.1	Gene:	Zfp40 / 690661	RGDID:	1593410	Length:	828	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	114/563 - (20%)
Similarity:	186/563 - (33%)	Gaps:	216/563 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1364 KCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCS 1428
            :|..|  |...|||....|| ..:|.....:.|..|...|..:::...|...|...:.|:|.:|.
  Rat   396 RCNEC--GKSLSSSSGLQRH-QRIHRGEKAYICAECDKCFIQKSQLKTHQKIHTGEKSYKCSECE 457

  Fly  1429 HVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYK----PRLQLQQHQLQP 1489
            ..|....:|.:| ||.|                    |.|     :|||    .:..:||..|:.
  Rat   458 KSFTVGSSLRIH-QRIH--------------------TGE-----KPYKCSECHKCFIQQAHLRR 496

  Fly  1490 QQKLQVQQH----QQQQKALQQLPQAQHHQQ---QQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQ 1547
            .||:...:.    .:.:|:.......:.||:   .::|....:.      .:..:|..:.::||:
  Rat   497 HQKIHTGEKPYKCSECEKSFTVGSDLRMHQKIHTGEKPYKCSDC------DKCFIQKAKLKKHQR 555

  Fly  1548 VLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPP 1612
            :...::|.:                            |.:||.|
  Rat   556 IHTGEKPYK----------------------------CSECEKC--------------------- 571

  Fly  1613 TVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASP 1677
                  .|:||                           .||.::|          :|
  Rat   572 ------FTVVS---------------------------DLRTHQK----------IH-------- 585

  Fly  1678 SPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHH 1742
                                |...|                    :.|..|::.|..:.:|::||
  Rat   586 --------------------TGEKP--------------------YKCSECDKCFIRKANLRRHH 610

  Fly  1743 QL-----------------------AHGALTT--MPYVCTICKRGYRMRTALHRHMESHDVEGRP 1782
            ::                       .|..:.|  .||.|. |.:.:.:.:.|.:|.:.|..| :|
  Rat   611 RIHTGEKPYKCSDCGKCFIQKANLRTHERIHTGEKPYKCE-CGKSFSVGSDLRKHQKCHTGE-KP 673

  Fly  1783 YECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDR 1846
            |:|:.|...|.|.:.|..|: .:|...||:.|.:|||.|..::.|:||.|.| ||..|:|..||:
  Rat   674 YKCSECHKCFIRKAHLRRHQ-RIHTGEKPYKCSDCGKCFIQKANLRTHQKIHTGEKPYKCSDCDK 737

  Fly  1847 TFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            .|.....||.|:|.|: |..|||..|..||...:..|.|.|.|
  Rat   738 CFIQKDHLRTHQRLHTGEKPYKCSECEKSFTGGSILRKHQKIH 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1396..1416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/43 (14%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1841..1861	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1868..1888	CDD:275368	7/19 (37%)
Zfp40	XP_038947408.1	KRAB	73..>115	CDD:214630
		C2H2 Zn finger	257..277	CDD:275368
		C2H2 Zn finger	285..305	CDD:275368
		COG5048	309..709	CDD:227381	83/490 (17%)
		C2H2 Zn finger	313..333	CDD:275368
		C2H2 Zn finger	341..361	CDD:275368
		C2H2 Zn finger	369..389	CDD:275368
		C2H2 Zn finger	397..417	CDD:275368	8/22 (36%)
		C2H2 Zn finger	425..445	CDD:275368	4/19 (21%)
		C2H2 Zn finger	453..473	CDD:275368	7/20 (35%)
		C2H2 Zn finger	481..501	CDD:275368	5/19 (26%)
		C2H2 Zn finger	509..529	CDD:275368	3/19 (16%)
		C2H2 Zn finger	537..557	CDD:275368	3/25 (12%)
		C2H2 Zn finger	565..585	CDD:275368	10/83 (12%)
		C2H2 Zn finger	593..613	CDD:275368	6/19 (32%)
		C2H2 Zn finger	621..641	CDD:275368	1/19 (5%)
		C2H2 Zn finger	650..668	CDD:275368	3/18 (17%)
		C2H2 Zn finger	676..696	CDD:275368	6/20 (30%)
		C2H2 Zn finger	704..724	CDD:275368	9/19 (47%)
		zf-H2C2_2	716..741	CDD:404364	12/24 (50%)
		C2H2 Zn finger	732..752	CDD:275368	8/19 (42%)
		zf-H2C2_2	744..768	CDD:404364	11/23 (48%)
		C2H2 Zn finger	760..780	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100