Protein Alignment mld and Zfp605

DIOPT Version :9

• Sequence 1: NP_001247289.1
• Gene: mld / 2768685
• FlyBaseID: FBgn0263490
• Length: 1965
• Species: Drosophila melanogaster
• Sequence 2: NP_001157468.1
• Gene: Zfp605 / 675812
• MGIID: 2444933
• Length: 694
• Species: Mus musculus
• Alignment Length: 884
• Identity: 164/884 - (18%)
• Similarity: 261/884 - (29%)
• Gaps: 357/884 - (40%)

  Fly  1091 QLVPQAQHQVVPHVQLQ--SQLVPHVQTQGTTTTVTYEQIYQQHIVQQTVQQSSNKMQVISLPSA 1153
            ||:...|..:...|.|:  |.|| .:..|.|...||::...|:..:......|.|.:: |.|.|
Mouse    21 QLLSPTQKSLYRDVMLENCSSLV-FLGNQTTKPDVTFKLDQQESRIMDEECLSQNFLE-IWLDS- 82

  Fly  1154 GSETTRQW-QTQQSQQQQQVQWSSVGGLEAIKSAPVESV---------------APTTTTYYISA 1202
               .:..| |.:|.:.::..:.:....||.:..:.:.||               ..:...::|..
Mouse    83 ---YSELWLQDEQDKPKRMERGNGDNVLEEVCHSSMNSVYLEMRFHICGTCGKNLKSPLNFFIPK 144

  Fly  1203 SDLYPQQTETYTML----------------------QPASNESYVIEQVNHQQQH-----CQQ-- 1238
            .:...::::....|                      :..||||   :.|..|:.|     |.:
Mouse   145 GNRVRKKSKVSKKLLFYLKFDKPYSKRKCHDCNKYRKANSNES---QLVTKQRTHSGIFLCMECG 206

  Fly  1239 QIQMSQQQ---HQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAATSNDVHQ 1300
            :|...:.|   |||.|.:::..|.........|:.::.                        :||
Mouse   207 RIFNKKSQLIVHQRNHTEEKPCQCNGYGKTFAQKSQLA------------------------IHQ 247

  Fly  1301 MQHT----QRQQ--------IRQQYQH---QQYQR----LQQPQQTRVVQSHPVLGMPGATSIST 1346
            ..|:    :||:        ::||..|   :.|.|    .::|.|.|...||.|
Mouse   248 KTHSGEEPERQKAFGGKSLGLQQQRTHTGQKPYARGKTYSRKPTQNRPAMSHAV----------- 301

  Fly  1347 KVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQ 1411
                       .:|  .:|..|  |..||..|:...| ...||...|:.|..|..||...::...
Mouse   302 -----------HKP--YRCGDC--GEVFSQKLKLIIH-RSTHPGEKPYKCSECRKAFFWNSQLIT 350

  Fly  1412 HILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPY 1476
            |..||...:.|.|.:|...|.....|..| ||.|                    |.|:..|.|..
Mouse   351 HRRSHRGKKPYVCSECEKAFRRNSLLIRH-QRIH--------------------TGEKPHRSREC 394

  Fly  1477 ------KPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQ---------QQPQLQQEV 1526
                  ||:|                              |:||...         ::...::..
Mouse   395 GEAFIGKPQL------------------------------AKHHMTHTGEKKCYGFEEVFFKKSK 429

  Fly  1527 LQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDC 1591
            |.:.|:..:..:|.:..:..::.    |::..|:..|.
Mouse   430 LMRHQKSHLGEKPNRCAEFGKIF----PEKSQLLTHQK--------------------------- 463

  Fly  1592 TSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYR 1656
                ||:.|                                                    |.||
Mouse   464 ----SHSGE----------------------------------------------------RPYR 472

  Fly  1657 KRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRT 1721
                                                                             
Mouse   473 ----------------------------------------------------------------- 472

  Fly  1722 SHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECN 1786
               |..|.:.|....||..|.:...|   ..||.|.:|.|.:..|:::..|..:|..| :|::|.
Mouse   473 ---CAECGKTFPGRSSLLSHQRTHTG---EKPYKCNLCGRAFSQRSSIISHQRTHTGE-KPFKCG 530

  Fly  1787 ICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEY 1850
            .|...|...|.|..||.| |...||..|.:|||.|..:..|..|.:.| ||..::|..|.:.|..
Mouse   531 DCGKAFTEKSNLLHHKRT-HTGEKPFGCSDCGKAFAWKPHLLQHQRIHTGEKPFECSECGKAFVQ 594

  Fly  1851 LKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            ..:|.||:|.|: |..|||..|..:|...|....|.|.|
Mouse   595 KVQLIKHQRHHTGEKIYKCSSCEKAFFEKTQLTIHQKIH 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	7/22 (32%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	7/19 (37%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	6/19 (32%)
Zfp605	NP_001157468.1	KRAB	7..62	CDD:214630	12/41 (29%)
		C2H2 Zn finger	173..196	CDD:275368	6/25 (24%)
		C2H2 Zn finger	202..222	CDD:275368	6/19 (32%)
		C2H2 Zn finger	230..250	CDD:275368	3/43 (7%)
		C2H2 Zn finger	307..327	CDD:275368	7/22 (32%)
		COG5048	331..693	CDD:227381	95/514 (18%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	7/20 (35%)
		C2H2 Zn finger	391..411	CDD:275368	7/49 (14%)
		C2H2 Zn finger	445..465	CDD:275368	3/54 (6%)
		C2H2 Zn finger	473..493	CDD:275368	6/19 (32%)
		C2H2 Zn finger	501..521	CDD:275368	5/19 (26%)
		C2H2 Zn finger	529..549	CDD:275368	8/20 (40%)
		C2H2 Zn finger	557..577	CDD:275368	7/19 (37%)
		C2H2 Zn finger	585..605	CDD:275368	7/19 (37%)
		C2H2 Zn finger	613..633	CDD:275368	6/19 (32%)
		C2H2 Zn finger	641..661	CDD:275368
		C2H2 Zn finger	669..689	CDD:275368

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100