DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and Zfp606

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_080388.2	Gene:	Zfp606 / 67370	MGIID:	1914620	Length:	794	Species:	Mus musculus

Alignment Length:	1063	Identity:	197/1063 - (18%)
Similarity:	329/1063 - (30%)	Gaps:	392/1063 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   879 YATLTEQESSVSSPPNPFEQSSVAE---PKDE----KPSATEDPFDNSNF----TNELIGFQNDI 932
            :.||.:|...:::|     :.||:.   |:|.    :.||.||.......    ..|.:.|::..
Mouse    10 WGTLMDQSWGMAAP-----EPSVSWALCPQDPAWHMEGSAEEDGRKTGGLPVAQVEEPVTFKDVA 69

  Fly   933 PCFENIETPEEGQNLHLELTQFLRDLQPSQSDPPAGEQVEKIEMETQPSTVQMDVQSNLPVQAAD 997
            ..|    |.||...|.|......||                :.:||....:.:..|
Mouse    70 VAF----TQEEWGQLDLVQRTLYRD----------------VMLETYGHLLSVGNQ--------- 105

  Fly   998 TQPQNESANHSPFESPISSPQVQSQIELQMEPQIETQMQPQIETRMQHDVLSVQS--PQNHQPQV 1060
                            |:.|:|.|.:|...||                  .||:.  |::..|:.
Mouse   106 ----------------IAKPEVISLLEQGEEP------------------WSVEQGYPKSSCPEW 136

  Fly  1061 QSHDQSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQHQVVPHVQLQSQLVPHVQTQGTTTTVTY 1125
            ..:.:|:.  .||.|   .:..:.|..|.:.|    :..:..:        |.:...|   .:.|
Mouse   137 MRNTESKA--LIPAQ---SVSEEEQSSNGMML----ERYIWDN--------PWLSRLG---VLGY 181

  Fly  1126 -EQIYQQHIVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQQQVQWSSVGGLEAI--KSAP 1187
             :|:...|:.|.|..:....||...|...|||.. :..|:.||....:....|..||..  ....
Mouse   182 GDQLEMYHMNQSTGMRQMVFMQKQVLSQRGSEFC-ELGTEYSQSLNLIPSQRVSQLERFYKPDTH 245

  Fly  1188 VESVAPTTTTYYI----------------SASDLYPQQTET----YTMLQPASNESYVIEQVNHQ 1232
            :||.:..:...|.                |...:||.:.:|    :.......:.:::|:..:|:
Mouse   246 LESWSCNSAIMYADKVTCENSDYNKAFCQSVQPVYPAKMQTGDNLFKCTDAVKSFNHIIQFGDHK 310

  Fly  1233 QQHCQQQIQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAATSND 1297
            ..|..:::...::.||..:|...          ||:.|::|    ...|..:......|....:.
Mouse   311 AVHTGEKLYGYKEYHQIFNQSPS----------LIEYPKLQ----IGGNQYEKYKEYENIFYFSS 361

  Fly  1298 VHQMQHTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLT 1362
            .  |:|.:...:.:.|::.:::::.                 |..|:.|:.|.   |....:|..
Mouse   362 F--MEHQKIGSVEKTYKYNEWEKVF-----------------GYDSLLTQHTS---TYTAEKPYE 404

  Fly  1363 L-KCRFCHNGPRFSSSLEYSRHIID---LHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQ 1423
            . ||         .:|..:|.::|.   .||...|:.|..|...|..|:..::|..:|..|:.|:
Mouse   405 FNKC---------GTSFIWSSYLIQHKKTHPGEKPYECDKCGKVFRNRSALTKHERTHTGVKPYE 460

  Fly  1424 CGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSER----RPRGRPYKPRLQLQQ 1484
            |.:|...|.....|.|| .|.|                    |.|:    ...|:.:.....|..
Mouse   461 CNKCGKAFSWNSHLIVH-TRIH--------------------TGEKPYVCNECGKSFNWNSHLIG 504

  Fly  1485 HQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVL 1549
            ||                                                        :.|
Mouse   505 HQ--------------------------------------------------------RTH---- 509

  Fly  1550 QVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTV 1614
                                        |..|...|.:|....|..||
Mouse   510 ----------------------------TGEKPFECTECGKSFSWSSH----------------- 529

  Fly  1615 LTPPSTIVSVPSPQPMVYSQHITMPSPEQSEP----DSTTTLRQYRKRGVIVGPQGPLHLATPVA 1675
                  :::           |:.|.:.|  :|    :.....|.|
Mouse   530 ------LIA-----------HMRMHTGE--KPFKCDECEKAFRDY-------------------- 555

  Fly  1676 SPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKK 1740
                     |:...|....|.|.|                       :.|..|.:.|:     ..
Mouse   556 ---------SALSKHERTHSGAKP-----------------------YKCTECGKSFS-----WS 583

  Fly  1741 HHQLAHGALTT--MPYVCTICKRGYRMRTALHRHMESHDVEG-RPYECNICRVRFPRPSQLTLHK 1802
            .|.:||....|  .||.|..|.:.:|.|:||.:|...|  .| :|||||.|.....:.:.|..|:
Mouse   584 SHLIAHQRTHTGEKPYNCQECGKAFRERSALTKHEIIH--SGIKPYECNKCGKSCSQMAHLVRHQ 646

  Fly  1803 ITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMF 1865
            .| |...||:.|::|||.|.....|..|.:.| ||..|:|:.|:|:|.....|..|||||: |..
Mouse   647 RT-HTGEKPYECNKCGKSFSQSCHLVAHRRIHTGEKPYKCNQCERSFNCSSHLIAHRRTHTGEKP 710

  Fly  1866 YKCKFCPSSFMRFTNFRAHMKTH 1888
            |:|..|..:|...::...|::.|
Mouse   711 YRCNECGKAFNESSSLIVHLRNH 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	4/25 (16%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1756..1776	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	7/19 (37%)
		zf-C2H2	1839..1861	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1841..1861	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1868..1888	CDD:275368	4/19 (21%)
Zfp606	NP_080388.2	KRAB	63..123	CDD:214630	19/122 (16%)
		KRAB	63..102	CDD:279668	11/58 (19%)
		COG5048	386..792	CDD:227381	112/565 (20%)
		C2H2 Zn finger	406..425	CDD:275368	5/27 (19%)
		zf-H2C2_2	417..442	CDD:290200	7/24 (29%)
		C2H2 Zn finger	433..453	CDD:275368	5/19 (26%)
		zf-H2C2_2	445..469	CDD:290200	6/23 (26%)
		C2H2 Zn finger	461..481	CDD:275368	7/20 (35%)
		zf-H2C2_2	473..497	CDD:290200	8/44 (18%)
		C2H2 Zn finger	489..509	CDD:275368	4/75 (5%)
		zf-H2C2_2	505..525	CDD:290200	7/107 (7%)
		C2H2 Zn finger	517..537	CDD:275368	6/53 (11%)
		zf-H2C2_2	529..552	CDD:290200	5/58 (9%)
		C2H2 Zn finger	545..565	CDD:275368	4/48 (8%)
		zf-H2C2_2	557..581	CDD:290200	6/46 (13%)
		C2H2 Zn finger	573..593	CDD:275368	6/24 (25%)
		zf-H2C2_2	585..608	CDD:290200	8/22 (36%)
		C2H2 Zn finger	601..621	CDD:275368	7/19 (37%)
		zf-C2H2	627..649	CDD:278523	8/22 (36%)
		C2H2 Zn finger	629..649	CDD:275368	6/20 (30%)
		zf-H2C2_2	641..666	CDD:290200	11/25 (44%)
		C2H2 Zn finger	657..677	CDD:275368	7/19 (37%)
		zf-H2C2_2	669..694	CDD:290200	10/24 (42%)
		C2H2 Zn finger	685..705	CDD:275368	8/19 (42%)
		zf-H2C2_2	697..721	CDD:290200	10/23 (43%)
		C2H2 Zn finger	713..733	CDD:275368	4/19 (21%)
		zf-H2C2_2	725..748	CDD:290200	2/9 (22%)
		zf-C2H2	739..761	CDD:278523
		C2H2 Zn finger	741..761	CDD:275368
		C2H2 Zn finger	769..789	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100