Protein Alignment mld and 2610021A01Rik

DIOPT Version :10

• Sequence 1: NP_001247289.1
• Gene: mld / 2768685
• FlyBaseID: FBgn0263490
• Length: 1965
• Species: Drosophila melanogaster
• Sequence 2: NP_001423129.1
• Gene: 2610021A01Rik / 668572
• MGIID: 1922662
• Length: 834
• Species: Mus musculus
• Alignment Length: 715
• Identity: 149/715 - (20%)
• Similarity: 236/715 - (33%)
• Gaps: 208/715 - (29%)

  Fly  1231 HQQQHCQQQIQMSQQQHQRQHQQQQA--------------QQQQQPIMILIQQPEIQQPVASASN 1281
            :||.:.|:::..|.||.:..::....              |:..:...:.::.|.|.:.  ..::
Mouse   238 YQQDYSQEKLSTSSQQDKIANESSNCSQCTEIKARGEFNRQRYDKYSKVSVESPSIDRD--KVND 300

  Fly  1282 PQQAP---------LHIYNAATSNDVHQMQHTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLG 1337
            .|:.|         .:.|...|.||   ..||     |::.|..:..:|:....:::| .||...
Mouse   301 IQRKPCLFMGSDKSFNFYLNMTQND---SSHT-----REKTQKYKVYKLEITSPSKLV-GHPRFF 356

  Fly  1338 MPGATSISTK-------VTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFN 1395
            :......|.|       :|.:.:....|.|    |:....|..||....| |....:|....|:.
Mouse   357 VQQKYRKSGKYSRNSSGLTRLKMLQPGGTP----CKSTECGKSFSQFSGY-RENYTIHTGEKPYK 416

  Fly  1396 CPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLK----TDPSGAV 1456
            |..|..:|...:....|...|...:.|:|.:|...|....:|.:|: |.|...|    || .|..
Mouse   417 CKICKRSFTTGSYLQAHQRIHTGEKPYRCKECGKSFTHGYSLQIHL-RLHTGEKPYKCTD-CGKA 479

  Fly  1457 KVEDVQLQITSERRPRGRPYK---------PRLQLQQHQL-----QPQQKLQVQQHQQQQKALQQ 1507
            ..|...|:.........:|||         .|..||.|..     :|.:.....:....:..|:
Mouse   480 FAEGSTLKSHHRIHTGEKPYKCKECGKSFATRSNLQGHSRIHTGDRPYKCADCGKSFTSRSCLR- 543

  Fly  1508 LPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEM 1572
                                            ..|:.|
Mouse   544 --------------------------------THHKTH--------------------------- 549

  Fly  1573 QASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQH-- 1635
                 |..|...|.:|     |.|     |.|..||:                       |.|
Mouse   550 -----TGEKSYKCKEC-----GRS-----FAEGSTLK-----------------------SHHRI 576

  Fly  1636 ITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPA 1700
            .|...|.:.:...    :.:.||                          |:...|....:...|.
Mouse   577 HTGEKPYKCKECG----KSFAKR--------------------------SNLQVHSRIHTGDKPY 611

  Fly  1701 SPAPPPSPAVASTVQVSELRT-----SHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICK 1760
            ..|......::|:...:..||     |:.|..|.:.||....|:.|:::..|   ..||:||.|.
Mouse   612 KCADCGKAFISSSCLRTHHRTHTGEKSYKCKECGKSFTQHSHLQTHYRIHTG---EKPYICTDCG 673

  Fly  1761 RGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTES 1825
            :.:....:|.||.::|..| :.|:|..|...|.:.|.|..|. .:|..:||..|.||||.|...|
Mouse   674 KSFSNSYSLQRHHKTHTGE-KSYKCKECGKSFSQGSHLQAHH-RIHSRNKPCKCKECGKGFAEGS 736

  Fly  1826 ALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            .||||.:.| ||..|:|..|.::|.....|:.|.|.|: |..||||.|..||...:..:.|.:.|
Mouse   737 TLKTHHRIHTGEKPYKCKECGKSFTEGSTLKAHHRIHTGEKPYKCKECGKSFTMASALKIHHRIH 801

  Fly  1889  1888
            Mouse   802  801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		PAT1	<959..>1109	CDD:401645
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		zf-C2H2	1812..1834	CDD:395048	11/21 (52%)
		C2H2 Zn finger	1814..1834	CDD:275368	11/19 (58%)
		zf-C2H2	1839..1861	CDD:395048	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		zf-C2H2	1866..1888	CDD:395048	8/21 (38%)
		C2H2 Zn finger	1868..1888	CDD:275368	6/19 (32%)
2610021A01Rik	NP_001423129.1	KRAB	18..78	CDD:214630
		C2H2 Zn finger	390..409	CDD:275368	5/19 (26%)
		COG5048	413..788	CDD:227381	110/509 (22%)
		C2H2 Zn finger	417..437	CDD:275368	4/19 (21%)
		C2H2 Zn finger	445..465	CDD:275368	6/20 (30%)
		C2H2 Zn finger	473..493	CDD:275368	5/20 (25%)
		C2H2 Zn finger	501..521	CDD:275368	4/19 (21%)
		C2H2 Zn finger	529..549	CDD:275368	2/52 (4%)
		C2H2 Zn finger	557..577	CDD:275368	10/52 (19%)
		C2H2 Zn finger	585..605	CDD:275368	4/49 (8%)
		C2H2 Zn finger	613..633	CDD:275368	3/19 (16%)
		C2H2 Zn finger	641..661	CDD:275368	6/19 (32%)
		C2H2 Zn finger	669..689	CDD:275368	6/19 (32%)
		C2H2 Zn finger	697..717	CDD:275368	6/20 (30%)
		C2H2 Zn finger	725..745	CDD:275368	11/19 (58%)
		C2H2 Zn finger	753..773	CDD:275368	6/19 (32%)
		C2H2 Zn finger	781..801	CDD:275368	6/19 (32%)
		zf-H2C2_2	793..818	CDD:463886	2/9 (22%)
		C2H2 Zn finger	809..829	CDD:275368