DRSC/TRiP Functional Genomics Resources

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Protein Alignment mld and ZNF574

DIOPT Version :9

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:NP_001317448.1 Gene:ZNF574 / 64763 HGNCID:26166 Length:986 Species:Homo sapiens


Alignment Length:931 Identity:180/931 - (19%)
Similarity:305/931 - (32%) Gaps:271/931 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1111 VPHVQTQGTTTTVTYEQ----IYQQH--IVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQ 1169
            :|..:.||....:|.|.    :|.:|  :..:..|...:..:|:              ..|:...
Human    79 MPGARAQGLAAAMTEESEETVLYIEHRYVCSECNQLYGSLEEVL--------------MHQNSHV 129

  Fly  1170 QQVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVIEQVNHQQQ 1234
            .|..:..||         |.....|..|...|.:.||  ||              ::::..:|..
Human   130 PQQHFELVG---------VADPGVTVATDTASGTGLY--QT--------------LVQESQYQCL 169

  Fly  1235 HCQQQIQMSQQ--QHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAATSND 1297
            .|.|.:....|  :||..|.:..|.|:..|               :..:|:..||      :|:.
Human   170 ECGQLLMSPSQLLEHQELHLKMMAPQEAVP---------------AEPSPKAPPL------SSST 213

  Fly  1298 VHQMQHTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLT 1362
            :|             |:....:.|...|:..:  :|      ..|.:....|..|.....|.|:.
Human   214 IH-------------YECVDCKALFASQELWL--NH------RQTHLRATPTKAPAPVVLGSPVV 257

  Fly  1363 LKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQC 1427
            |       ||....:.....|  ....|.........|.|.|..|:    :::...:..|:|.:|
Human   258 L-------GPPVGQARVAVEH--SYRKAEEGGEGATVPSAAATTTE----VVTEVELLLYKCSEC 309

  Fly  1428 SHVF--PAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQ 1490
            |.:|  ||                         :.::.|.|....|.....:|.||.:.....|.
Human   310 SQLFQLPA-------------------------DFLEHQATHFPAPVPESQEPALQQEVQASSPA 349

  Fly  1491 Q-------KLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQL------QVQVQPQQH 1542
            :       .|....|..:.:..:.:.:.:..::.::....:......|:|      |:.:.|.|.
Human   350 EVPVSQPDPLPASDHSYELRNGEAIGRDRRGRRARRNNSGEAGGAATQELFCSACDQLFLSPHQL 414

  Fly  1543 QQH-----QQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDC------EDCTSGHS 1596
            |||     :.|.:.      ||.....|.||:::......:......|.||      |.....|.
Human   415 QQHLRSHREGVFKC------PLCSRVFPSPSSLDQHLGDHSSESHFLCVDCGLAFGTEALLLAHR 473

  Fly  1597 HANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGV- 1660
            .|:                 .|:.:.|.|..:..|               :.|..|...|..|| 
Human   474 RAH-----------------TPNPLHSCPCGKTFV---------------NLTKFLYHRRTHGVG 506

  Fly  1661 -------IVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSE 1718
                   .|.|:.|: :..|..:|:.:..|.:..    ||.|..|.|.||.|             
Human   507 GVPLPTTPVPPEEPV-IGFPEPAPAETGEPEAPE----PPVSEETSAGPAAP------------- 553

  Fly  1719 LRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPY 1783
              .::.||.|...|...:.|.:|.:..|  .....:.|:||.:.::.::.:..|:.:|..| ||:
Human   554 --GTYRCLLCSREFGKALQLTRHQRFVH--RLERRHKCSICGKMFKKKSHVRNHLRTHTGE-RPF 613

  Fly  1784 ECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFHGE-LGYQCDGCDRT 1847
            .|..|...|..|:.|..|::| |...:|:.|.:|||.|...|.|:.|...|.: ..|:|..|...
Human   614 PCPDCSKPFNSPANLARHRLT-HTGERPYRCGDCGKAFTQSSTLRQHRLVHAQHFPYRCQECGVR 677

  Fly  1848 FEYLKELRKHRRTHS-EMFYKCKFCPSSFM-------------------RFTNFRAHMKTHLPLG 1892
            |.....|..||..|: |..|||:.||.||:                   |..:..|...:.|.|.
Human   678 FHRPYRLLMHRYHHTGEYPYKCRECPRSFLLRRLLEVHQLVVHAGRQPHRCPSCGAAFPSSLRLR 742

  Fly  1893 VFRNEDAASKSP---------------SNNNSHASSDKLENPATPIEETPLTPMSSGGHLYHSPD 1942
            ..|...||:::|               :...:|.::.....|...:.:.|..|.:          
Human   743 EHRCAAAAAQAPRRFECGTCGKKVGSAARLQAHEAAHAAAGPGEVLAKEPPAPRA---------- 797

  Fly  1943 EYPNSVESCAGNSVALESYAT 1963
              |.:..:...:..||.|.||
Human   798 --PRATRAPVASPAALGSTAT 816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
C2H2 Zn finger 1365..1388 CDD:275368 3/22 (14%)
C2H2 Zn finger 1396..1416 CDD:275368 4/19 (21%)
C2H2 Zn finger 1424..1445 CDD:275368 6/22 (27%)
C2H2 Zn finger 1725..1746 CDD:275368 6/20 (30%)
C2H2 Zn finger 1756..1776 CDD:275368 4/19 (21%)
C2H2 Zn finger 1785..1806 CDD:275368 7/20 (35%)
C2H2 Zn finger 1814..1834 CDD:275368 8/19 (42%)
zf-C2H2 1839..1861 CDD:278523 7/21 (33%)
C2H2 Zn finger 1841..1861 CDD:275368 6/19 (32%)
C2H2 Zn finger 1868..1888 CDD:275368 7/38 (18%)
ZNF574NP_001317448.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142332
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24376
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.030

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