DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mld and ZFP62

DIOPT Version :9

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:NP_001166109.1 Gene:ZFP62 / 643836 HGNCID:23241 Length:900 Species:Homo sapiens


Alignment Length:1048 Identity:191/1048 - (18%)
Similarity:343/1048 - (32%) Gaps:335/1048 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   989 SNLPVQAADTQPQNESANHSPFES---PISSPQVQSQI--ELQMEPQIETQMQPQIETRMQHDVL 1048
            |:|.....|.:|..|..|.....|   .:..|..:|::  ....:.::|.|.:..:|.||:.|..
Human     2 SHLKTSTEDEEPTEEYENVGNAASKWPKVEDPMPESKVGDTCVWDSKVENQQKKPVENRMKEDKS 66

  Fly  1049 SVQSPQNHQPQVQSHDQSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQ-AQHQVVPHVQLQSQLVP 1112
            |::         ::..:::....|..:.|.:     ..:.:|.|.|| ..||.:|..|..|:...
Human    67 SIR---------EAISKAKSTANIKTEQEGE-----ASEKSLHLSPQHITHQTMPIGQRGSEQGK 117

  Fly  1113 HVQTQGTTTTVTYEQ------------------IYQQHIVQQTVQQSSNKMQVISLPSAGSETTR 1159
            .|:....|:..:.:|                  .|...:||..:..:..|               
Human   118 RVENINGTSYPSLQQKTNAVKKLHKCDECGKSFKYNSRLVQHKIMHTGEK--------------- 167

  Fly  1160 QWQTQQSQQQQQVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESY 1224
                       :.:....||                 |:..|:|....::..|       ..:.|
Human   168 -----------RYECDDCGG-----------------TFRSSSSLRVHKRIHT-------GEKPY 197

  Fly  1225 VIEQ-----------VNHQQQH----------CQQQIQMSQ--QQHQRQHQQQ---------QAQ 1257
            ..|:           :||:..|          |.:....|.  .||:|.|..:         :|.
Human   198 KCEECGKAYMSYSSLINHKSTHSGEKNCKCDECGKSFNYSSVLDQHKRIHTGEKPYECGECGKAF 262

  Fly  1258 QQQQPIMILIQQPEIQQPVASASNPQQAPL--HIYNAATSNDVHQMQHTQRQ------------Q 1308
            :....:       .:.:.:.:...|.:..:  ..::.::...||:..||..:            .
Human   263 RNSSGL-------RVHKRIHTGEKPYECDICGKTFSNSSGLRVHKRIHTGEKPYECDECGKAFIT 320

  Fly  1309 IRQQYQHQQYQRLQQPQQ----------TRVVQSHPVL--------------------GMPGATS 1343
            .|....|:......:|.:          :.::..|.|:                    |:.....
Human   321 CRTLLNHKSIHFGDKPYKCDECEKSFNYSSLLIQHKVIHTGEKPYECDECGKAFRNSSGLIVHKR 385

  Fly  1344 ISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTK 1408
            |.|...|            .||..|.....:||.|...:.|   ||......|..|..:|:..:.
Human   386 IHTGEKP------------YKCDVCGKAFSYSSGLAVHKSI---HPGKKAHECKECGKSFSYNSL 435

  Fly  1409 RSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPR- 1472
            ..||...|...:.|.|..|...|.....|.|| :|.|                    |.|:..: 
Human   436 LLQHRTIHTGERPYVCDVCGKTFRNNAGLKVH-RRLH--------------------TGEKPYKC 479

  Fly  1473 ---GRPYKPRLQLQQHQ-----LQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQ--EVL 1527
               |:.|..|..|:.|:     .:|.:....::......||:|  ..:.|.:::.....:  :..
Human   480 DVCGKAYISRSSLKNHKGIHLGEKPYKCSYCEKSFNYSSALEQ--HKRIHTREKPFGCDECGKAF 542

  Fly  1528 QQVQQLQVQVQPQQHQQHQQVLQVQQPQQ-----------QPLMQPQSPHPSTVEMQASPTTPRK 1581
            :....|:|         |:::...::|.:           ..|:..:|.||.           .|
Human   543 RNNSGLKV---------HKRIHTGERPYKCEECGKAYISLSSLINHKSVHPG-----------EK 587

  Fly  1582 ILCCPDCEDC------TSGHS--HANEQFEELQTLQAPPTVLTPPSTIVSVPS-PQPMVYSQHIT 1637
            ...|.:||..      .:.|.  |..|:               |....|...| ....:.|||..
Human   588 PFKCDECEKAFITYRTLTNHKKVHLGEK---------------PYKCDVCEKSFNYTSLLSQHRR 637

  Fly  1638 MPSPEQS-EPD-------STTTLRQYRKRGVIVGPQ-------GPLHLATPVASPSPSSSPSSST 1687
            :.:.|:. |.|       :.::|:.:::  :..|.:       |..:::            .||.
Human   638 VHTREKPYECDRCEKVFRNNSSLKVHKR--IHTGERPYECDVCGKAYIS------------HSSL 688

  Fly  1688 VDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTM 1752
            ::|         .|..|.              ||.|.|..|.:.|.:..:|..|.::..|   ..
Human   689 INH---------KSTHPG--------------RTPHTCDECGKAFFSSRTLISHKRVHLG---EK 727

  Fly  1753 PYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDEC 1817
            |:.|..|.:.:...:.|.:|...|..| :||.|:.|...|...|.||:|| .:|...||:.||||
Human   728 PFKCVECGKSFSYSSLLSQHKRIHTGE-KPYVCDRCGKAFRNSSGLTVHK-RIHTGEKPYECDEC 790

  Fly  1818 GKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTN 1880
            ||.:.:.|:|..|...| |:..|.|: |.::|.|...|.:|:|.|: :..|:|..|..:|...:|
Human   791 GKAYISHSSLINHKSVHQGKQPYNCE-CGKSFNYRSVLDQHKRIHTGKKPYRCNECGKAFNIRSN 854

  Fly  1881 FRAHMKTH 1888
            ...|.:||
Human   855 LTKHKRTH 862

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
C2H2 Zn finger 1365..1388 CDD:275368 6/22 (27%)
C2H2 Zn finger 1396..1416 CDD:275368 5/19 (26%)
C2H2 Zn finger 1424..1445 CDD:275368 7/20 (35%)
C2H2 Zn finger 1725..1746 CDD:275368 5/20 (25%)
C2H2 Zn finger 1756..1776 CDD:275368 4/19 (21%)
C2H2 Zn finger 1785..1806 CDD:275368 8/20 (40%)
C2H2 Zn finger 1814..1834 CDD:275368 9/19 (47%)
zf-C2H2 1839..1861 CDD:278523 8/21 (38%)
C2H2 Zn finger 1841..1861 CDD:275368 7/19 (37%)
C2H2 Zn finger 1868..1888 CDD:275368 5/19 (26%)
ZFP62NP_001166109.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..97 19/108 (18%)
COG5048 125..552 CDD:227381 76/530 (14%)
C2H2 Zn finger 143..163 CDD:275368 3/19 (16%)
C2H2 Zn finger 171..191 CDD:275368 5/36 (14%)
C2H2 Zn finger 199..219 CDD:275368 3/19 (16%)
C2H2 Zn finger 227..247 CDD:275368 5/19 (26%)
C2H2 Zn finger 255..275 CDD:275368 1/26 (4%)
C2H2 Zn finger 283..303 CDD:275368 2/19 (11%)
C2H2 Zn finger 311..331 CDD:275368 2/19 (11%)
C2H2 Zn finger 339..359 CDD:275368 2/19 (11%)
C2H2 Zn finger 367..387 CDD:275368 1/19 (5%)
C2H2 Zn finger 395..415 CDD:275368 6/22 (27%)
C2H2 Zn finger 423..443 CDD:275368 5/19 (26%)
COG5048 447..860 CDD:227381 108/513 (21%)
C2H2 Zn finger 451..471 CDD:275368 7/20 (35%)
C2H2 Zn finger 479..499 CDD:275368 5/19 (26%)
C2H2 Zn finger 507..527 CDD:275368 3/21 (14%)
C2H2 Zn finger 535..555 CDD:275368 3/28 (11%)
C2H2 Zn finger 563..583 CDD:275368 2/19 (11%)
C2H2 Zn finger 591..611 CDD:275368 4/19 (21%)
C2H2 Zn finger 619..639 CDD:275368 5/19 (26%)
C2H2 Zn finger 647..667 CDD:275368 2/21 (10%)
C2H2 Zn finger 675..695 CDD:275368 5/40 (13%)
C2H2 Zn finger 703..723 CDD:275368 5/19 (26%)
C2H2 Zn finger 731..751 CDD:275368 4/19 (21%)
C2H2 Zn finger 759..779 CDD:275368 8/20 (40%)
C2H2 Zn finger 787..807 CDD:275368 9/19 (47%)
C2H2 Zn finger 815..834 CDD:275368 7/19 (37%)
C2H2 Zn finger 842..862 CDD:275368 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24376
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

Return to query results.
Submit another query.