DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and si:dkeyp-84f3.9

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_691447.5	Gene:	si:dkeyp-84f3.9 / 562992	ZFINID:	ZDB-GENE-131127-66	Length:	939	Species:	Danio rerio

Alignment Length:	1016	Identity:	190/1016 - (18%)
Similarity:	318/1016 - (31%)	Gaps:	344/1016 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1168 QQQQVQWSSVGGLEAI--------KSAPVESVAPTTTTYY-----ISASDLYPQQTETYTMLQPA 1219
            |:|.|:  |||..|.|        ::..||..:|..|...     .:|......:.:..|..||.
Zfish    19 QEQSVK--SVGMGEFISKGLALSSQNREVEEPSPAATNVQPEPLSCNADGKGSSEADVNTFPQPF 81

  Fly  1220 SNESYVIEQVNHQQQHCQQQIQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVA------S 1278
            |    :::..|...:.|.:.....:...........:|.:..|....:.:|:....|:      |
Zfish    82 S----LVKNTNMDARRCSEDFDQPEANSDCVSSTTDSQPKSLPTNTELNKPQTSTQVSDKTDEIS 142

  Fly  1279 ASNPQQ-------------APLHI-YNAATSN---------DVH-----------QMQHTQRQQI 1309
            ::.|::             .|... |:|::||         |:|           :||.:..:.:
Zfish   143 SNQPERESDMNEALYANVLTPAEADYDASSSNKGDSNYSDKDIHESTADPMVSDVEMQDSLSETL 207

  Fly  1310 RQ----------QYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTP----IPVTAARGRP 1360
            .|          ..:.||....:|.::|.....:       |...|.:||.    .| :..||||
Zfish   208 NQNDETLDDEDPSTEEQQESNSEQNKETPAEDDN-------AKENSMEVTENKHGFP-SFTRGRP 264

  Fly  1361 ----LTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFA-----------GRTKRS 1410
                ..::|..|..  .|:.:..|..| :.:|....||.|..|..|||           .|::..
Zfish   265 RKEKRVIRCEHCSR--PFNHASAYIIH-LRIHTGEKPFVCQDCGKAFAQLSNLRSHSKVHRSRSR 326

  Fly  1411 QHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERR----- 1470
            :|...:.|..:....:.......:|..|.|..                     ||||:||
Zfish   327 KHRNQNKVTTEKSADESQVYSTDKKETDFHSN---------------------QITSKRRRGRGK 370

  Fly  1471 PRGRP-----------YKPRLQLQQHQLQPQQKLQVQQHQQQQ--------KALQQLPQAQHHQQ 1516
            .:|:|           ||..|           |:.::.|..::        |:..|...|:.|::
Zfish   371 GKGKPQTCPICAKVFCYKSVL-----------KIHLRIHSGEKPYSCKVCGKSFTQACTARVHER 424

  Fly  1517 QQ---QPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTT 1578
            ..   :|.|..:..:...||             ..|::...:.:..|     |.:..||:.....
Zfish   425 VHWSIRPFLCTKCGKGFSQL-------------GPLKLHTCEGKTRM-----HNTVKEMETDGVV 471

  Fly  1579 PRKILCCPDCEDCTS----------GHSHANEQ-----------FEELQTLQAPPTVLTPPSTIV 1622
            ..:   |..|:.|.|          ||......           ..||.|.......:....:..
Zfish   472 SFR---CHLCKTCFSTRDEYELHVQGHKDTQRYSCDRCKQTFSLLSELHTHSKHCGAIRLAKSKF 533

  Fly  1623 SVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSS- 1686
            |..||             |.:|:|.|                  |::..||....||:.||...
Zfish   534 SGYSP-------------PHRSQPKS------------------PMNRRTPPRVRSPAKSPQKEI 567

  Fly  1687 ---------TVDHIPPASPATPASPAP----PPSPAVASTVQVSELRTSHHCLYCEERFTNEISL 1738
                     ::...||...|...|..|    ..|..:.|:..||:|.::||
Zfish   568 FSPRKLKRCSLLACPPQILAASDSDFPNNLYSVSQPIKSSYFVSQLNSTHH-------------- 618

  Fly  1739 KKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKI 1803
                     ......|.|..|.|.:|....|..||.:|. .|:.:.|..|...|...::..:|:.
Zfish   619 ---------KADPRSYFCPRCGRIFRHVGRLRAHMLTHS-RGKNFTCVYCNRVFKTWNKFWIHQR 673

  Fly  1804 TVHLLSKPHTCDECGKQFGTESALKTHIKFHGEL-GYQCDGCDRTFEYLKELRKHRRT--HSEMF 1865
            ....:.....|.:||:.|....:...|::.|.|| .:.|..|.|||...::||.|:..  ||.|.
Zfish   674 LHRQIRGRFFCPKCGRGFRFVESYNEHVQKHPELNAHACPFCTRTFSNAQKLRNHQEKWHHSTMP 738

  Fly  1866 YKCKFCPSSFMRFTNFRAHMKTHL---PLGVFRNED----------------------------- 1898
            :.|::|...|...|..:.|...|.   |:....|.|
Zfish   739 FVCEYCGKGFESATILKRHKVVHCTIDPIETLYNADLQSTGHPYECGACSACFGNLDLLFHHQLQ 803

  Fly  1899 --AASKSPS--------NNNSHASSDKLENPATPIEETPL----------------TPMSSGGHL 1937
              ||.|.|:        ::.||::..:..:..:|:..:||                .|..|..|.
Zfish   804 HKAADKEPTAMKGFQRQSSVSHSNGAERPHSVSPLRSSPLKKPQQNPNQSPSTIKTLPQLSTNHQ 868

  Fly  1938 --------------YHSPDEYPNSVESCAGNSVALESYATT 1964
                          .|:.:..|.:.||...|...|::.:||
Zfish   869 TLPGSKTNEEQMLENHTKNRVPVTAESNNSNKSVLKTESTT 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	5/22 (23%)
		C2H2 Zn finger	1396..1416	CDD:275368	7/30 (23%)
		C2H2 Zn finger	1424..1445	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1725..1746	CDD:275368	0/20 (0%)
		C2H2 Zn finger	1756..1776	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1785..1806	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1814..1834	CDD:275368	5/19 (26%)
		zf-C2H2	1839..1861	CDD:278523	8/23 (35%)
		C2H2 Zn finger	1841..1861	CDD:275368	8/21 (38%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
si:dkeyp-84f3.9	XP_691447.5	C2H2 Zn finger	273..293	CDD:275368	5/22 (23%)
		zf-H2C2_2	289..310	CDD:290200	8/21 (38%)
		C2H2 Zn finger	378..398	CDD:275368	4/30 (13%)
		zf-H2C2_2	391..415	CDD:290200	4/34 (12%)
		C2H2 Zn finger	406..426	CDD:275368	4/19 (21%)
		C2H2 Zn finger	434..450	CDD:275368	3/28 (11%)
		C2H2 Zn finger	627..647	CDD:275368	7/19 (37%)
		C2H2 Zn finger	655..675	CDD:275368	4/19 (21%)
		C2H2 Zn finger	684..704	CDD:275368	5/19 (26%)
		LIM	712..764	CDD:295319	17/51 (33%)
		C2H2 Zn finger	712..733	CDD:275368	8/20 (40%)
		C2H2 Zn finger	741..761	CDD:275368	5/19 (26%)
		C2H2 Zn finger	784..804	CDD:275368	0/19 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100