DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and ZNF302

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_016882467.1	Gene:	ZNF302 / 55900	HGNCID:	13848	Length:	444	Species:	Homo sapiens

Alignment Length:	148	Identity:	52/148 - (35%)
Similarity:	76/148 - (51%)	Gaps:	12/148 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly  1751 TMP--------YVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHL 1807
            |:|        |.|:.|.:.:..::.|.||...|..| :||||..|...|...|.||.|:|: |.
Human   235 TLPQTCNREKIYTCSECGKAFGKQSILSRHWRIHTGE-KPYECRECGKTFSHGSSLTRHQIS-HS 297

  Fly  1808 LSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKF 1870
            ..||:.|.||||.|...|:|..|...| ||..|:|..|.::|..:..|.:|.|.|: |..|:|:.
Human   298 GEKPYKCIECGKAFSHGSSLTNHQSTHTGEKPYECMNCGKSFSRVSLLIQHLRIHTQEKRYECRI 362

  Fly  1871 CPSSFMRFTNFRAHMKTH 1888
            |..:|:..::...|.|:|
Human   363 CGKAFIHSSSLIHHQKSH 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368
		C2H2 Zn finger	1396..1416	CDD:275368
		C2H2 Zn finger	1424..1445	CDD:275368
		C2H2 Zn finger	1725..1746	CDD:275368
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
ZNF302	XP_016882467.1	KRAB	48..109	CDD:214630
		COG5048	<151..393	CDD:227381	52/148 (35%)
		C2H2 Zn finger	248..268	CDD:275368	5/19 (26%)
		C2H2 Zn finger	276..296	CDD:275368	8/20 (40%)
		C2H2 Zn finger	304..324	CDD:275368	9/19 (47%)
		C2H2 Zn finger	332..352	CDD:275368	6/19 (32%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		C2H2 Zn finger	388..408	CDD:275368
		C2H2 Zn finger	416..436	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142327
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930