DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and ZNF107

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	557	Identity:	118/557 - (21%)
Similarity:	180/557 - (32%)	Gaps:	194/557 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1373 RFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKAL 1437
            :||:|..|.|.    |.....|.|..|..:|...::.:||...|..|..|:|.:|...|.....|
Human   200 KFSNSNRYKRR----HTGNKHFKCKECSKSFCVLSQLTQHRRIHTRVNSYKCEECGKAFNWFSTL 260

  Fly  1438 DVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQ 1502
            ..| :|.|                    |.|     :|||                    .::..
Human   261 TKH-KRIH--------------------TGE-----KPYK--------------------CEECG 279

  Fly  1503 KALQQLPQAQHHQ---QQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQS 1564
            ||..|..|...|:   .:::|...:|..:..:|          ..|..:.::....::|....:.
Human   280 KAFNQSSQLTRHKIIHTEEKPNKCEECGKAFKQ----------ASHLTIHKIIHTGEKPYKYEEC 334

  Fly  1565 PHPSTVEMQASPTTPRKILCCPD----CEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVP 1625
               ..|..|:|..|.:|||...:    |::|    ..|...|..|
Human   335 ---GKVFSQSSHLTTQKILHTGENLYKCKEC----GKAFNLFSNL-------------------- 372

  Fly  1626 SPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDH 1690
                   :.|                     ||         :|     |...|..........:
Human   373 -------TNH---------------------KR---------IH-----AGEKPYKCKECGRAFN 395

  Fly  1691 IPPASPATPASPAPPPSPAVASTVQVSE-LRTS---HHCLYCEERFTNEISLKKHHQLAHGALTT 1751
            |                   :|.:...| :.|.   :.|..|::.|...:.|..|.::   .:..
Human   396 I-------------------SSNLNKQEKIHTGGKLNKCEECDKAFNRSLKLTAHKKI---LMEE 438

  Fly  1752 MPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLL-------- 1808
            .||.|..|.:.:...:.|.||...|..| :||:|..|...|.:.|.||.|| .:|..
Human   439 KPYKCEECGKVFNQFSTLTRHKIIHTGE-KPYKCKECGKAFNQSSNLTEHK-KIHTAEKSYKCEE 501

  Fly  1809 --------------------SKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLK 1852
                                .||:.|:||||.|...|.|..|.|.| ||..|:|:.|||.|....
Human   502 CGKAFNQHSNLINHRKIYSGEKPYKCEECGKAFNRSSTLTRHKKIHTGEKPYKCEECDRAFSQSS 566

  Fly  1853 ELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            .|.:|::.|: |..|||:.|..:|.||:....|.:.|
Human   567 NLTEHKKIHTGEKPYKCEECGKAFNRFSTLTKHKRIH 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	5/14 (36%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	10/19 (53%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	6/19 (32%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630
		C2H2 Zn finger	191..211	CDD:275368	5/14 (36%)
		C2H2 Zn finger	219..239	CDD:275368	5/19 (26%)
		COG5048	243..621	CDD:227381	104/510 (20%)
		C2H2 Zn finger	247..267	CDD:275368	6/20 (30%)
		C2H2 Zn finger	275..295	CDD:275368	5/19 (26%)
		C2H2 Zn finger	303..323	CDD:275368	3/29 (10%)
		C2H2 Zn finger	331..351	CDD:275368	6/22 (27%)
		C2H2 Zn finger	359..379	CDD:275368	8/80 (10%)
		C2H2 Zn finger	387..407	CDD:275368	3/38 (8%)
		C2H2 Zn finger	415..435	CDD:275368	5/22 (23%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
		C2H2 Zn finger	471..491	CDD:275368	8/20 (40%)
		C2H2 Zn finger	499..519	CDD:275368	0/19 (0%)
		C2H2 Zn finger	527..547	CDD:275368	10/19 (53%)
		COG5048	551..>863	CDD:227381	19/53 (36%)
		C2H2 Zn finger	555..575	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		C2H2 Zn finger	611..631	CDD:275368
		C2H2 Zn finger	639..659	CDD:275368
		C2H2 Zn finger	699..715	CDD:275368
		C2H2 Zn finger	723..743	CDD:275368
		C2H2 Zn finger	751..771	CDD:275368
		C2H2 Zn finger	779..799	CDD:275368
		C2H2 Zn finger	807..827	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	863..883	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142192
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030