DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp458

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001136434.1	Gene:	Zfp458 / 499563	RGDID:	1559684	Length:	752	Species:	Rattus norvegicus

Alignment Length:	840	Identity:	157/840 - (18%)
Similarity:	265/840 - (31%)	Gaps:	288/840 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1188 VESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVI---EQVN------------------- 1230
            :|.:.|...:.|   .|:..:.......|..||::.|:|   ||:.
  Rat    19 LEYLGPAQWSLY---RDVMLENYSNLVFLGLASSKPYLITLLEQIKEPSDMKKREAITLHPGGKC 80

  Fly  1231 HQQQHCQQQIQMSQ--QQHQRQHQQQQAQQQQQ-------PIMILIQQPEIQQPVASASNPQQAP 1286
            :..:.|.|..:..:  |.||:.|.:.:..:.::       |.::            ||.......
  Rat    81 YMCEECGQVFEWKKVLQNHQKIHLRAKPYKCEECGKSFHFPSLL------------SAHKRNHTG 133

  Fly  1287 LHIYN---------AATSNDVHQMQHTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGAT 1342
            ..:||         |::...:|:..||.::....:...:.:.......|.:||.:       |..
  Rat   134 EKLYNCEICCKAFHASSLLSLHKRIHTGQKPHESENYSKDFHYPSLLSQNKVVHT-------GEK 191

  Fly  1343 SIST----KVTPIPVTAARGRPLTL-----KCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPH 1398
            |...    |....|.|.::.:.:..     ||..|.....:.|.|...:.|   |....|:.|..
  Rat   192 SYQCEDHGKTFHYPSTFSKHKKIHTGEKPHKCEVCGKAFDYPSRLSNHKRI---HTGEKPYKCEV 253

  Fly  1399 CPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVH--IQRFHMTLKTDPSGAVKVEDV 1461
            |..||...:|.|||.:.|...:.|:|..|...|.....|..|  |.......|.|..
  Rat   254 CDRAFHDPSKLSQHKIIHTGEKPYKCDVCGKAFHYPSILSKHKIIHTEENLCKCDIC-------- 310

  Fly  1462 QLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEV 1526
                       |:.:...|.|.||::       |...::..|. :...:|.::
  Rat   311 -----------GKAFHYPLLLSQHKI-------VHTGEKPYKC-EDCGKAFYY------------ 344

  Fly  1527 LQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDC 1591
                        |.:..:|:::...::|.:                               ||.|
  Rat   345 ------------PSRLSRHKKIHTGEKPYK-------------------------------CEVC 366

  Fly  1592 TSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEP-----DSTTT 1651
            .....:                        :|:.|...:|:::.    :|.:.|.     |..:.
  Rat   367 GKAFHY------------------------LSILSKHKIVHTEE----NPYKCEVCGKAFDYPSR 403

  Fly  1652 LRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQV 1716
            |..::|          :|                            |...|
  Rat   404 LSNHKK----------IH----------------------------TEEKP-------------- 416

  Fly  1717 SELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGR 1781
                  :.|..|...|....||:||..:..|   ..||.|.:|.:.:...:.|.:|.:.| .|.:
  Rat   417 ------YKCEVCGNAFCFSSSLRKHKIIHTG---EKPYKCEVCGKAFGSPSRLSKHKKIH-TEEK 471

  Fly  1782 PYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCD 1845
            ||:|.:|...|..||.|::|| .:|...||:.|:.|||.|...|.|..|.:.| ||..|:|:.|.
  Rat   472 PYKCEVCGKAFHFPSLLSVHK-RIHTGEKPYKCEICGKAFYCASTLSVHKRIHTGENNYKCEVCG 535

  Fly  1846 RTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNE--DAASKSPSNN 1907
            :.|.....|..|||.|: |..|||:.|..:|...:....|.:.|.....::.|  ..|...||..
  Rat   536 KAFHCPSTLSVHRRIHTQEKPYKCEVCGQAFHVSSKLSYHKRIHTAEKPYKCEICGKAFYYPSRL 600

  Fly  1908 NSH-------------ASSDKLENPATPIEETPLTPMSSGGHLYH---SPDEYPNSVESC 1951
            :.|             |....|:.|:.              |..|   :|.|.|:..|.|
  Rat   601 SKHKIVHMGEKRYHGQACGKALDYPSR--------------HSKHKKLNPGEKPHKCEIC 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	5/22 (23%)
		C2H2 Zn finger	1396..1416	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1725..1746	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	4/19 (21%)
Zfp458	NP_001136434.1	KRAB	5..63	CDD:214630	11/46 (24%)
		C2H2 Zn finger	83..103	CDD:275368	5/19 (26%)
		COG5048	107..520	CDD:227381	104/607 (17%)
		C2H2 Zn finger	111..131	CDD:275368	3/31 (10%)
		C2H2 Zn finger	139..159	CDD:275368	2/19 (11%)
		C2H2 Zn finger	195..215	CDD:275368	3/19 (16%)
		C2H2 Zn finger	223..243	CDD:275368	5/22 (23%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		C2H2 Zn finger	307..327	CDD:275368	6/45 (13%)
		C2H2 Zn finger	335..355	CDD:275368	3/44 (7%)
		C2H2 Zn finger	363..383	CDD:275368	5/43 (12%)
		C2H2 Zn finger	391..411	CDD:275368	4/29 (14%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	4/19 (21%)
		C2H2 Zn finger	475..495	CDD:275368	8/20 (40%)
		SFP1	<497..576	CDD:227516	28/78 (36%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	4/19 (21%)
		SFP1	<582..661	CDD:227516	15/79 (19%)
		C2H2 Zn finger	587..607	CDD:275368	5/19 (26%)
		COG5048	629..>727	CDD:227381	6/18 (33%)
		C2H2 Zn finger	643..663	CDD:275368	2/4 (50%)
		C2H2 Zn finger	671..691	CDD:275368
		C2H2 Zn finger	699..715	CDD:275368
		C2H2 Zn finger	727..747	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100