DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp51

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_006228071.2	Gene:	Zfp51 / 499056	RGDID:	1560046	Length:	779	Species:	Rattus norvegicus

Alignment Length:	855	Identity:	169/855 - (19%)
Similarity:	292/855 - (34%)	Gaps:	239/855 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1132 HIVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQQQVQWSSVGGLEAIKSAPVE------- 1189
            |:....:.|:...::...||       |:.:|....|.|||.:|.:     :|..|.|
  Rat    11 HVQSSLITQTCPPVEQNKLP-------RRPKTVAKDQGQQVIYSLL-----LKDKPKEEKQKEMA 63

  Fly  1190 ----SVAPTTTTYYISASDLYPQ---------QTETY--TMLQPASN----ESYVIEQVNHQ--- 1232
                :::....|:...|.| :||         |...|  .||:..||    |:|.|....||
  Rat    64 HSPVNMSQCLLTFGDVAVD-FPQEEWECLDSAQRALYIDVMLENYSNLVSVENYCICDTVHQHVK 127

  Fly  1233 --QQHCQQQIQMSQQQHQRQH-----QQQQAQQ-------QQQPIMILIQQPEIQQPVASASNPQ 1283
              :..||.. ::|:..|...|     :.:.|:.       :.:...:...:|:..:...:...|.
  Rat   128 TKKDSCQCN-ELSEMLHDSPHCALYKRGETAETSNNYRCCKDRDASVDSSEPDQHKSTRTGEEPC 191

  Fly  1284 QA-----PLHIYNAATSND-VHQMQHTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHP-VLGMPG- 1340
            ::     .|::.::...:| ::......|::....|.:..|..:   ||:..::..| ..|..|
  Rat   192 KSEDCERSLNVCSSIIQDDRLYTANKKHREEEYNDYFNCTYNLM---QQSLYLEEKPHKCGKCGK 253

  Fly  1341 ATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAG 1405
            ..|.|:::..........:|  .||..|.......::|:..:.   ||....|:.|..|..:|..
  Rat   254 CFSTSSRLIKHQRIHTGKKP--YKCTICDKSYNQCANLKIHQR---LHTGEKPYKCKECGKSFRQ 313

  Fly  1406 RTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERR 1470
            .:....|...|...:.|:|.||...|....:...| |:.|                    |||..
  Rat   314 TSVLKSHQKMHTGEKPYKCKQCDKSFAHSSSFRTH-QKIH--------------------TSEEH 357

  Fly  1471 ---PR-GRPYKPRLQLQQHQLQPQQKLQVQQHQQQQ--------KALQQLPQAQHHQQQQQPQLQ 1523
               |. ||.:        |||...:| ..:.|..::        ::.......:.||:...|::.
  Rat   358 CSCPECGREF--------HQLSHFRK-HYRLHTGEKPYKCNECGRSFTHYASLRWHQKTHSPEIY 413

  Fly  1524 QEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDC 1588
            .|..:..:..   ::....::|.::...::|.:..:........||::......|..|...|.:|
  Rat   414 YECKECGKSF---IELSHLKRHYRIHTGEKPYKCEVCDKSFTVNSTLKTHQKIHTGEKPYKCREC 475

  Fly  1589 EDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLR 1653
            :...:.:||                                                      ||
  Rat   476 DKSFTHNSH------------------------------------------------------LR 486

  Fly  1654 QYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSE 1718
            :::                                                        :|...|
  Rat   487 RHQ--------------------------------------------------------SVHTGE 495

  Fly  1719 LRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPY 1783
              ..:.|..|::.||...:||:|.:|..|..|   |.|..|.:.:...:.|..|:..|..| |||
  Rat   496 --RPYKCKDCDKSFTECSTLKEHQKLHTGEKT---YKCGECSKSFSQHSYLRSHLRVHTGE-RPY 554

  Fly  1784 ECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRT 1847
            .|..|...|...|.|..|: .:|...||:.|.||.|.|..:|.|:||.:.| ||..|.|..|||:
  Rat   555 VCKECGKSFTTCSTLRTHQ-KIHTGEKPYKCRECNKSFTQDSHLRTHHRVHTGERPYSCKECDRS 618

  Fly  1848 FEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDA--ASKSPSNNNS 1909
            |.....||.|::.|: |..||||.|..||:|.::.|.|.:.|.....::.:|.  :....||...
  Rat   619 FTRCSYLRAHQKIHTGEKPYKCKDCDISFLRISSLRIHQEIHTGEKPYKCKDCDISFNQISNLKR 683

  Fly  1910 HASSDKLENP 1919
            |......|.|
  Rat   684 HQKLHTGEKP 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	3/22 (14%)
		C2H2 Zn finger	1396..1416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1725..1746	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1841..1861	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1868..1888	CDD:275368	8/19 (42%)
Zfp51	XP_006228071.2	KRAB	73..113	CDD:396083	11/40 (28%)
		COG5048	231..647	CDD:227381	115/573 (20%)
		C2H2 Zn finger	248..268	CDD:275368	4/19 (21%)
		C2H2 Zn finger	276..296	CDD:275368	3/22 (14%)
		C2H2 Zn finger	304..324	CDD:275368	4/19 (21%)
		C2H2 Zn finger	332..352	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..380	CDD:275368	7/28 (25%)
		C2H2 Zn finger	416..436	CDD:275368	1/22 (5%)
		C2H2 Zn finger	444..464	CDD:275368	2/19 (11%)
		C2H2 Zn finger	472..492	CDD:275368	6/129 (5%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	528..548	CDD:275368	4/19 (21%)
		C2H2 Zn finger	556..576	CDD:275368	6/20 (30%)
		C2H2 Zn finger	584..604	CDD:275368	9/19 (47%)
		C2H2 Zn finger	612..632	CDD:275368	8/19 (42%)
		C2H2 Zn finger	640..660	CDD:275368	8/19 (42%)
		C2H2 Zn finger	668..688	CDD:275368	4/19 (21%)
		zf-H2C2_2	680..705	CDD:404364	4/14 (29%)
		C2H2 Zn finger	696..715	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100