DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp457

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001003666.2	Gene:	Zfp457 / 431706	MGIID:	2664334	Length:	647	Species:	Mus musculus

Alignment Length:	582	Identity:	127/582 - (21%)
Similarity:	198/582 - (34%)	Gaps:	116/582 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1385 IDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLK 1449
            |.:||....:.|..|...|..:.....|...|..|:.|:|.:|...|.....|..| :|.|...|
Mouse    72 ITVHPGGKCYTCKECGKGFEHKKVYQNHWRIHLRVKSYKCEECGKSFHFPSLLSAH-KRKHTGEK 135

  Fly  1450 TDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHH 1514
            ...|     ||           .|:.:.....|.|:::       |...::..|. :...:..|:
Mouse   136 LYSS-----ED-----------SGKDFHCPSLLSQNKI-------VHTEEKPYKC-EDCGKGFHY 176

  Fly  1515 QQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTP 1579
                                    |.:...|:::...::|.:..:......:||.:.......|.
Mouse   177 ------------------------PSRLSDHKKIHTGEKPHKCEICGKAFDYPSRLSNHKRIHTG 217

  Fly  1580 RKILCCPDCEDCTSGHSHANEQFEELQTLQAP------------PTVLTPPSTIVSVPSP----- 1627
            .|...|..| |.|........|.:.:.|.:.|            |::|:....|.:...|
Mouse   218 EKPYKCELC-DKTFHDPSKLSQHKIIHTGEKPYKCEVCGKTFHYPSILSKHKIIHTGEKPYKCEV 281

  Fly  1628 ------QPMVYSQHITMPSPEQ-SEPDSTTTLRQYRKRGVIVGPQGPLHLATPV---ASPSPSSS 1682
                  .|.:.|:|..:.:.|. .:.|.......|           ||.|:...   ....|...
Mouse   282 CGKTFHYPSILSKHKIIHTKENLCKCDICGKAFHY-----------PLLLSQHKIVHTGKKPYKC 335

  Fly  1683 PSSSTVDHIP---PASPATPASPAP------------PPSPAVASTVQVSELRTSHHCLYCEERF 1732
            .:.....|.|   .....|.....|            |...:....|...|  ..:.|..|.:.|
Mouse   336 ENCDKSFHYPSKLSRHKKTHTGEKPYKCEVCGKDFYYPSRLSKHKIVHTEE--NPYKCEVCGKAF 398

  Fly  1733 TNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQ 1797
            .....|..|.:: |  ....||.|.:|.:.:...::||:|...|..| :||:|:||...|..||:
Mouse   399 DYPSRLSNHKKI-H--TEEKPYKCEVCGKAFCFLSSLHKHKIIHTGE-KPYKCDICGKAFGSPSR 459

  Fly  1798 LTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTH 1861
            |:.:..| |...||:.|:.|||.|...|.|..|.:.| ||..|:|:.|.:.|....:|..|.|.|
Mouse   460 LSKNSKT-HTGEKPYKCEVCGKAFHCPSILSVHKRIHTGEKPYKCEVCGKAFNIPSKLSHHNRIH 523

  Fly  1862 S-EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDAASKS---PSNNNSHASSDKLENP 1919
            : |..|||:.|..:|...:....|.|.|.. |...|.:..||.   ||..:.|......|.|
Mouse   524 TREKPYKCEVCGKAFHYPSRLSKHKKIHTG-GNPYNAEMCSKGFNYPSRLSEHKKLTTEEKP 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	1/2 (50%)
		C2H2 Zn finger	1396..1416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
Zfp457	NP_001003666.2	zf-H2C2_2	600..624	CDD:290200
		KRAB	5..63	CDD:214630
		KRAB	5..44	CDD:279668
		C2H2 Zn finger	83..103	CDD:275368	4/19 (21%)
		C2H2 Zn finger	111..131	CDD:275368	6/20 (30%)
		C2H2 Zn finger	167..187	CDD:275368	3/44 (7%)
		zf-H2C2_2	180..204	CDD:290200	2/23 (9%)
		COG5048	191..620	CDD:227381	98/414 (24%)
		C2H2 Zn finger	195..215	CDD:275368	2/19 (11%)
		zf-H2C2_2	208..231	CDD:290200	6/23 (26%)
		C2H2 Zn finger	223..243	CDD:275368	5/20 (25%)
		zf-H2C2_2	236..260	CDD:290200	3/23 (13%)
		C2H2 Zn finger	251..271	CDD:275368	2/19 (11%)
		zf-H2C2_2	264..288	CDD:290200	3/23 (13%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		C2H2 Zn finger	307..327	CDD:275368	5/30 (17%)
		C2H2 Zn finger	335..355	CDD:275368	2/19 (11%)
		zf-H2C2_2	348..372	CDD:290200	2/23 (9%)
		C2H2 Zn finger	363..383	CDD:275368	1/19 (5%)
		C2H2 Zn finger	391..411	CDD:275368	5/20 (25%)
		zf-H2C2_2	404..426	CDD:290200	7/24 (29%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	8/20 (40%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	488..511	CDD:290200	8/22 (36%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	5/19 (26%)
		C2H2 Zn finger	587..607	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100