DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and CG6791

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster

Alignment Length:	1521	Identity:	270/1521 - (17%)
Similarity:	462/1521 - (30%)	Gaps:	540/1521 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   642 TSSTETSESQPKAVEQLESMGKQESYALPQNMEAHESVQQTQTVDESDSADQREIIVSIPLEVLD 706
            :|..|..|:: ..|.:||.   .|.|....:    :.:..|..:|..|:.|          ::||
  Fly    12 SSDFEEGEAE-SGVAELED---SEQYGNGND----DFLGDTAILDSGDAID----------DLLD 58

  Fly   707 ENLQRRLCVDPETEAANRQSADPKEFALRPDDVNNNENDENFCQSATADSFNSAVALRTNKIEAT 771
            .....|    .|.:...:.|.:||:    ||.    ::|..|       .||....:
  Fly    59 AEEDER----EEEDDYEKNSKEPKQ----PDP----DDDALF-------DFNMEPIV-------- 96

  Fly   772 PPGGTDSDDTDTDEVPIVPSGPTPMDFMAEFAKHC---ANGIEQL------KVTTPVPSPTPSDL 827
                   |..:.....:.|:||..........:|.   |.|..:|      :.||...:.|..:.
  Fly    97 -------DIAEPQRPSLAPAGPMSQQVRPPMQRHSFPGAGGRPRLGSGLSVRPTTSQINATDENG 154

  Fly   828 VPLNDLEAKQKLEVEMNDVETTLNGILNEMQDQHMYTPNCAHIDEF-------LTPAD--YATLT 883
            ||:|       .|:.:..:.....|   |.:.|..:..:..||.::       .||.|  |....
  Fly   155 VPIN-------YELGVVYICPACGG---EFRQQDHWKRHMNHIHKYNTLRGLNFTPLDKLYQRCR 209

  Fly   884 E--QESSVSSPPNPFEQSSVAEPKDEKPSATEDPF---------DNSNFTNELIGFQNDIPCFEN 937
            |  :..::.|..|..           |...|..||         ....:..:|:.....:.|.|.
  Fly   210 ECNKRIAMHSRENLL-----------KHKFTHLPFRCTKCYICKREYKYRQDLMVHLRMVHCDEV 263

  Fly   938 IETPEEGQNLHLELT--------QFLRDLQPSQSDPPAGEQVEKIEME------------TQPST 982
            :....||.|.....|        |.||:....::| ..||:.::||:.            ||..|
  Fly   264 VAMMREGYNAAGRKTRVRESRTEQLLREKSFREND-DLGEESDRIEVRNELLEPDADESGTQEQT 327

  Fly   983 VQMDVQSNLPVQAADTQPQNE-SANHSPFESPISSPQVQSQIELQMEPQIETQMQPQIETRMQHD 1046
            |..:|..    :.|.|:...| ..::..:..|          :...:.....|....||  ..||
  Fly   328 VSEEVSK----KKAGTRGAAELCEDYIHYMCP----------DCGTDCDTHAQWSQHIE--FVHD 376

  Fly  1047 VLSVQSPQNHQPQVQSHDQSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQHQVVPHVQLQSQLV 1111
            .:|     ......:|.|......:....:.|         ||::             .|::...
  Fly   377 YVS-----RRGLNFRSVDMQMQCLECKKIVTP---------NTIK-------------SLRAHKF 414

  Fly  1112 PHV-QTQGTTTTVTYEQIYQQH--IVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQQQVQ 1173
            .|: |.:.....:.|:. |..|  |::..:||                  ....|..|:..::..
  Fly   415 SHLSQPEWLRCKLCYKG-YTDHQEIIRHLLQQ------------------HHMDTLMSEDAEEED 460

  Fly  1174 WSSVGGLE----------AIKSAPVESVAPTTTTYY---------ISASDLYPQQTETYTMLQPA 1219
            ..:...:|          ....||::..:|    |:         ||:.|::....:   .|.|.
  Fly   461 GDAPSAIEDECDGDNGNGEGNGAPLDEDSP----YFEDAPRRGGRISSDDIFEPHID---YLCPQ 518

  Fly  1220 SNESYVIEQVNHQQQHCQQQIQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASA---SN 1281
            ..:.::      :::|.:..:.|:...:.......:...::|     ::..|..:.:.:|   .|
  Fly   519 CGKEFI------EKKHWRTHVVMAHSMNDLSKLNFEMINERQ-----LKCTECDKIITNAYGIQN 572

  Fly  1282 PQQAPLHIYNAATSNDVHQMQHTQ-RQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSIS 1345
            .||              |::.|.. :...|.:..|:.|  ..:....:.:.:|..:|.|...|..
  Fly   573 AQQ--------------HRITHLPFKAYARCRKCHKSY--TDRKGLVKHLATHHRVGWPRKLSGG 621

  Fly  1346 TKVTPIPVTAARGRPL---------TLKCRFCHNGPR--------FSSSLEYSRHIIDLHPAVAP 1393
               .|.|:.....:|.         |.:..:..:..:        |...::...   |.:|...|
  Fly   622 ---CPAPILTPAKQPRKQIVTVANETYEIIYLDDVDQGGMEEDNDFGEQMQAEE---DEYPIAPP 680

  Fly  1394 FNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHI--QRFHMTL-------- 1448
               |..|......|.:..|       |:|:|..|..:|..|.|:.|||  :|...|:
  Fly   681 ---PPSPPPPPQPTTQGNH-------QRYKCVHCGTLFATQAAVRVHISEKRCRKTVVRRRRQPV 735

  Fly  1449 --KTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQH--QLQPQQKLQVQQHQQQQKALQQLP 1509
              ..|||    |..|:..........|..||.:.:.::|  ::....|.|....:|..|...|..
  Fly   736 MSSADPS----VPTVEQNYIFLCPSCGFEYKTQFEWRRHINEVHNFDKRQYLNMRQLDKYRYQCT 796

  Fly  1510 QAQHHQQQQQPQLQQEVL--QQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEM 1572
            |.            ::::  .:::.||     ..|.:|                  .|:
  Fly   797 QC------------KDIVCNSKLKGLQ-----DHHFRH------------------LPY------ 820

  Fly  1573 QASPTTPRKILCCPDCEDC------TSGHSHANEQFEELQTLQAPPTVLTPPSTIV--------- 1622
                   |..|.|..|..|      .:.|..|.....:.:|    ||::|.|..::
  Fly   821 -------RLYLKCLICGTCYNHKPNIAAHLRARHSIFDRET----PTMITKPKQVLGRYKDNSRE 874

  Fly  1623 --SVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSS 1685
              .:|||.|                                          .|..:|:|.|.|:.
  Fly   875 NPKLPSPPP------------------------------------------APALAPAPPSPPAC 897

  Fly  1686 STVDHIPPASPATPAS-----PAP---PPSPAVASTVQVSELRTSHH-----------CLYCEER 1731
            |       :|.|..||     |.|   |..||..:|::.|   .|:|           |..|.:.
  Fly   898 S-------SSAAASASSRSLKPQPGGLPARPAGLNTLEDS---ISYHNAVDLDFITYFCPKCNQN 952

  Fly  1732 FTNEISLKKHHQLAHG----------ALTTMPYVCTICKRGYRMRTALHR-----HMESH---DV 1778
            |.:....:||....|.          .:....|:|..|   |:..|..|.     .::||   .:
  Fly   953 FDSHAFWRKHIVEQHNFNSREGLNFRQIDNHHYLCLEC---YKRVTVTHTKGAIGQLQSHKFRHL 1014

  Fly  1779 EGRPYECNICRVRFPR---------------------------PSQLTLHKITVHLLSKPHTCDE 1816
            ..|.::|..|...|.|                           |.|.||.....||     ||.:
  Fly  1015 PHRSFKCLTCGGEFVRKQMFFKHLNRDTNRCDNRPHREFDDDEPDQDTLLSTIYHL-----TCPQ 1074

  Fly  1817 CGKQFGT--ESALKTHIKFH--------------GELGYQCDGCDRTFEYLKE--LRKHRRTH-- 1861
            ||..|.|  :...:.||..|              ||..|:|..||...|..::  |:.||..|
  Fly  1075 CGDNFKTHNKKEWREHINDHHGLTKLELLHMTKVGEDVYRCQDCDEELETNRQWVLQFHRFQHLP 1139

  Fly  1862 SEMFYKCKFCPSS----------FMRFTNFRAHMKTHLP-LG----------VFRNEDAASKSPS 1905
            ...:.:||.|..|          .......:.|::.|.| ||          :.::|....:...
  Fly  1140 HAAYIRCKLCKQSSADGADAVGELHSLRELQQHIRKHHPGLGDAEMISLIEQIIQDEKEQEEGTE 1204

  Fly  1906 NNNSHASSDKLENPATPIEETPLTPM 1931
            ..|..      ||| |..:..|..|:
  Fly  1205 QTNDG------ENP-TGQDSGPYMPL 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	2/30 (7%)
		C2H2 Zn finger	1396..1416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1424..1445	CDD:275368	9/22 (41%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/24 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/47 (17%)
		C2H2 Zn finger	1814..1834	CDD:275368	7/21 (33%)
		zf-C2H2	1839..1861	CDD:278523	8/23 (35%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/21 (33%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/29 (17%)
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368	4/23 (17%)
		C2H2 Zn finger	208..230	CDD:275368	4/32 (13%)
		C2H2 Zn finger	235..256	CDD:275368	1/20 (5%)
		C2H2 Zn finger	516..532	CDD:275368	2/21 (10%)
		C2H2 Zn finger	557..580	CDD:275368	6/36 (17%)
		C2H2 Zn finger	589..609	CDD:275368	2/21 (10%)
		COG5236	<939..>1096	CDD:227561	34/164 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439975
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930