DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and ZNF808

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001034975.2	Gene:	ZNF808 / 388558	HGNCID:	33230	Length:	903	Species:	Homo sapiens

Alignment Length:	880	Identity:	167/880 - (18%)
Similarity:	287/880 - (32%)	Gaps:	280/880 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1135 QQTVQQSSNKMQVISLPSAGSETTR---------QWQTQQSQQQ---QQVQWSSVGGLEAIKSAP 1187
            ::..|:...|...::||. |..|.|         :|:.....|:   ::|...:...|||:..:.
Human     4 EEAAQKRKGKESGMALPQ-GRLTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNLEAVDISS 67

  Fly  1188 VESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVI---------EQVNHQQQHCQQ----- 1238
            ...:....:|...:...::     |.|:.:   ::||.|         :::::.:..||:
Human    68 KHMMKEVLSTGQGNREVIH-----TGTLQR---HQSYHIGDFCFQEIEKEIHNIEFQCQEDERNG 124

  Fly  1239 ---------QIQMSQQQHQRQHQQQQAQQQQ--------QPIMILIQ------------------ 1268
                     ::..|..||..:|...:..:.|        .|.:.:.|
Human   125 HEAPTTKIKKLTGSTDQHDHRHAGNKPIKDQLGSSFYSHLPELHIFQIKGEIANQLEKSTSDASS 189

  Fly  1269 ---------QPEI-------QQPVASASNPQQAPLHI-------------YNAATSNDVHQMQHT 1304
                     :|:|       ..|:.|:..||:..:|:             :|.::....||:.|.
Human   190 VSTSQRISCRPQIHISNNYGNNPLNSSLLPQKQEVHMREKSFPCNESGKAFNCSSLLRKHQIPHL 254

  Fly  1305 QRQQIR-----QQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLK 1364
            ..:|.:     :.:.|:||....:       :.|            |...|            .|
Human   255 GDKQYKCDVCGKLFNHKQYLACHR-------RCH------------TGEKP------------YK 288

  Fly  1365 CRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSH 1429
            |:.|.....:.|||.....   ||..|.|:.|..|...|...:....|...|...:.|:|.:|..
Human   289 CKECGKSFSYKSSLTCHHR---LHTGVKPYKCNECGKVFRQNSALVIHKAIHTGEKPYKCNECGK 350

  Fly  1430 VFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRL---------QLQQH 1485
            .|..|..|..| ||.|..:|                         |||.::         .|..|
Human   351 AFNQQSHLSRH-QRLHTGVK-------------------------PYKCKICEKAFACHSYLANH 389

  Fly  1486 QLQPQQKLQVQQHQQQQKALQ-------QLPQAQHH--QQQQQPQLQQE---VLQQVQQLQVQVQ 1538
                   .::...::..|..:       |...|:||  ...::|...:|   |..|...|
Human   390 -------TRIHSGEKTYKCNECGKAFNHQSSLARHHILHTGEKPYKCEECDKVFSQKSTL----- 442

  Fly  1539 PQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHS------- 1596
                ::|:::...::|.:..:........|.:.......|..|...|.:|....|..|
Human   443 ----ERHKRIHTGEKPYKCKVCDTAFTCNSQLARHRRIHTGEKTYKCNECRKTFSRRSSLLCHRR 503

  Fly  1597 -HANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGV 1660
             |:.|  :..:..|...|.....|          :||  |..:.:.|:|.  ..|...:...|..
Human   504 LHSGE--KPYKCNQCGNTFRHRAS----------LVY--HRRLHTLEKSY--KCTVCNKVFMRNS 552

  Fly  1661 IVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHC 1725
            ::.....:|.|                                                :..:.|
Human   553 VLAVHTRIHTA------------------------------------------------KKPYKC 569

  Fly  1726 LYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRV 1790
            ..|.:.|..:..|.:|.:|..|   ..||.|..|.:.:..::||..|...|..| :||.|.:|..
Human   570 NECGKAFNQQSHLSRHRRLHTG---EKPYKCEACDKVFGQKSALESHKRIHTGE-KPYRCQVCDT 630

  Fly  1791 RFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKEL 1854
            .|...|||..| ..:|...|.:.|:||||.|..:|:|..|.:.| ||..|:|..||:.|.....:
Human   631 AFTWNSQLARH-TRIHTGEKTYKCNECGKTFSYKSSLVWHRRLHGGEKSYKCKVCDKAFVCRSYV 694

  Fly  1855 RKHRRTHSEMF-YKCKFCPSSFMRFTNFRAHMKTH 1888
            .||.|.||.|. |||..|..:|...::...|.:.|
Human   695 AKHTRIHSGMKPYKCNECSKTFSNRSSLVCHRRIH 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	5/22 (23%)
		C2H2 Zn finger	1396..1416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1424..1445	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	4/19 (21%)
ZNF808	NP_001034975.2	KRAB	24..64	CDD:307490	8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..154		4/32 (13%)
		COG5048	206..585	CDD:227381	84/518 (16%)
		C2H2 Zn finger	233..253	CDD:275368	3/19 (16%)
		C2H2 Zn finger	261..281	CDD:275368	3/26 (12%)
		C2H2 Zn finger	289..309	CDD:275368	5/22 (23%)
		C2H2 Zn finger	317..337	CDD:275368	4/19 (21%)
		C2H2 Zn finger	345..365	CDD:275368	8/20 (40%)
		C2H2 Zn finger	373..393	CDD:275368	2/26 (8%)
		COG5048	397..839	CDD:227381	90/411 (22%)
		C2H2 Zn finger	401..421	CDD:275368	4/19 (21%)
		C2H2 Zn finger	429..449	CDD:275368	5/28 (18%)
		C2H2 Zn finger	457..477	CDD:275368	1/19 (5%)
		C2H2 Zn finger	485..505	CDD:275368	4/19 (21%)
		C2H2 Zn finger	513..533	CDD:275368	6/31 (19%)
		C2H2 Zn finger	541..561	CDD:275368	2/19 (11%)
		C2H2 Zn finger	569..589	CDD:275368	5/19 (26%)
		C2H2 Zn finger	597..617	CDD:275368	5/19 (26%)
		C2H2 Zn finger	625..645	CDD:275368	7/20 (35%)
		C2H2 Zn finger	653..673	CDD:275368	9/19 (47%)
		C2H2 Zn finger	681..701	CDD:275368	7/19 (37%)
		C2H2 Zn finger	709..729	CDD:275368	4/19 (21%)
		C2H2 Zn finger	737..757	CDD:275368
		C2H2 Zn finger	765..785	CDD:275368
		C2H2 Zn finger	793..813	CDD:275368
		SFP1	<816..893	CDD:227516
		C2H2 Zn finger	821..841	CDD:275368
		C2H2 Zn finger	849..869	CDD:275368
		C2H2 Zn finger	877..897	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100