DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp948

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001002008.1	Gene:	Zfp948 / 381066	MGIID:	3040683	Length:	667	Species:	Mus musculus

Alignment Length:	746	Identity:	151/746 - (20%)
Similarity:	247/746 - (33%)	Gaps:	183/746 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1168 QQQQVQWSSVGGL--EAIKSAPVESVAPT-TTTYYISASDLYPQQTETYTMLQPASNESYVIEQV 1229
            :::..|.:.:|.:  |....||..:...| |:..|...:|    |..:.....|...:|....:.
Mouse    68 EKESRQCNELGEMLHEPTNCAPYNTSDTTETSNNYRCCND----QDASVDSSNPDRLKSVHTGEE 128

  Fly  1230 NHQQQHCQQQIQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAAT 1294
            ..:.:.|::...::|.|......::|.|::.....      .....:.|:|..|....:..|...
Mouse   129 RCEYKDCEKSSSIAQDQRTNSANKEQRQEKHGGHF------SSTHSLKSSSIAQDQRTNSANKEQ 187

  Fly  1295 SNDVH----QMQHTQRQQI----RQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPI 1351
            ..:.|    ...|:..||.    .::||..|.||.........:...          |.|...|
Mouse   188 GQEKHGGHFSSTHSLMQQAIFNREKRYQCGQCQRCFSTSANLTIHQR----------IHTGEKP- 241

  Fly  1352 PVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSH 1416
                       .||.||.......::|:..:.   ||....|:.|..|..:|...:....|...|
Mouse   242 -----------YKCNFCDKSFAQCTTLKTHQR---LHTGEKPYKCKECGKSFPQLSALKSHQKMH 292

  Fly  1417 HVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLK-TDPSGAVKVEDVQLQITSERRPRG-RPYK-- 1477
            ...:.|:|.:|...|....:...| |:.|...| |.|.....:..:....:..|...| .|||
Mouse   293 TGEKPYKCKECDRFFAHCSSFRRH-QKTHRAKKHTGPDCGKDLHQLSHFKSDHRLHTGENPYKCS 356

  Fly  1478 ------PRLQL-QQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQV 1535
                  |..:| :.||.....::. .:.::..|:..:|.|.:.|.:..    ....|.:.:....
Mouse   357 ECDRSFPHYELFRIHQKTHSSEID-YECEECGKSFTELLQLRRHYKIH----SGATLYKCRDCDK 416

  Fly  1536 QVQPQQH-QQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHAN 1599
            ......| |:||.:...::|.:....:....|.|.:....|..|..|...|.:|:...:.:|
Mouse   417 SFTQYSHLQKHQTIHTGERPYKCKDCEKSFLHNSLLRRHQSVHTGEKPYKCKECDKSFTRNS--- 478

  Fly  1600 EQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGP 1664
                                                               .|||::|
Mouse   479 ---------------------------------------------------ILRQHQK------- 485

  Fly  1665 QGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCE 1729
               :|                            |...|                    :.|:.|:
Mouse   486 ---IH----------------------------TKEKP--------------------YKCVECD 499

  Fly  1730 ERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPR 1794
            :.|| :::..:.||..|  ....||.||:|.:.:.....|..|...|..| |||.|..|...|..
Mouse   500 KSFT-QLTYLRTHQRVH--TKEKPYNCTVCDKSFTTGATLRIHQRVHTGE-RPYRCTECGKSFRE 560

  Fly  1795 PSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHR 1858
            .:.|..|| .:|...||:.|..|.|.|...|.|:.|.:.| ||..|:|..||::|.....||||:
Mouse   561 GTTLRTHK-KIHTGEKPYNCTVCDKSFIRYSHLQRHQRVHTGEKPYKCMECDKSFTECFLLRKHQ 624

  Fly  1859 RTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            |.|: |..||||.|..:|:..:|.|.|.|.|
Mouse   625 RIHTEEKPYKCKDCDLAFVCISNLRKHQKNH 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	4/22 (18%)
		C2H2 Zn finger	1396..1416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1424..1445	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	7/19 (37%)
		zf-C2H2	1839..1861	CDD:278523	10/21 (48%)
		C2H2 Zn finger	1841..1861	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1868..1888	CDD:275368	8/19 (42%)
Zfp948	NP_001002008.1	KRAB	12..52	CDD:396083
		COG5048	195..595	CDD:227381	102/547 (19%)
		C2H2 Zn finger	216..236	CDD:275368	3/29 (10%)
		C2H2 Zn finger	244..264	CDD:275368	4/22 (18%)
		C2H2 Zn finger	272..292	CDD:275368	4/19 (21%)
		C2H2 Zn finger	300..320	CDD:275368	5/20 (25%)
		C2H2 Zn finger	328..346	CDD:275368	1/17 (6%)
		C2H2 Zn finger	355..375	CDD:275368	4/19 (21%)
		C2H2 Zn finger	383..403	CDD:275368	4/19 (21%)
		C2H2 Zn finger	411..431	CDD:275368	4/19 (21%)
		C2H2 Zn finger	439..459	CDD:275368	3/19 (16%)
		C2H2 Zn finger	467..487	CDD:275368	7/83 (8%)
		C2H2 Zn finger	495..515	CDD:275368	6/20 (30%)
		C2H2 Zn finger	523..543	CDD:275368	5/19 (26%)
		C2H2 Zn finger	551..571	CDD:275368	6/20 (30%)
		C2H2 Zn finger	579..599	CDD:275368	7/19 (37%)
		zf-H2C2_2	591..615	CDD:404364	9/23 (39%)
		C2H2 Zn finger	607..627	CDD:275368	9/19 (47%)
		C2H2 Zn finger	635..655	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100