DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and Zfp26

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001102465.2	Gene:	Zfp26 / 367033	RGDID:	1565847	Length:	956	Species:	Rattus norvegicus

Alignment Length:	1084	Identity:	214/1084 - (19%)
Similarity:	369/1084 - (34%)	Gaps:	323/1084 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   928 FQNDIPCFENIETPEEGQNL---------HLELTQ---FLRDLQPSQSDPPAGEQVEKIEMETQP 980
            |.:|..|.:..||  ||::.         .::..|   .|:|  |:||..|....||.   .|..
  Rat    12 FSDDQICSQEEET--EGESTLGEDCDKDEAVDCAQEEWTLKD--PTQSSRPGDVAVED---HTNL 69

  Fly   981 STVQMDVQSNLPVQAADTQPQNE-SANHSPFESPISSPQVQSQIELQMEPQIETQMQPQIETRMQ 1044
            :|.:::.|    :|..|:.|:.: .|.|:..|:..........:.:....:..|.:.| |:..:.
  Rat    70 ATAELEKQ----LQTKDSAPEQDFLARHTFMETQQVDAVTFEDVAVDFTQEEWTSLDP-IQRTLY 129

  Fly  1045 HDVLSVQSPQN--------HQPQVQSHDQSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQHQVV 1101
            .:|: :::.||        .:|.:.|            .:|.::|:...||..||
  Rat   130 REVM-LENYQNLATVGGQLFKPSLIS------------WLERKVELTVMEQGILQ---------- 171

  Fly  1102 PHVQLQSQLVPHVQTQGTTTTVTYEQIYQQHIVQQTVQQS------SNKMQVISLPSAGSETTRQ 1160
                   :...|::|:.|                 .:||.      ||.||:....|.|
  Rat   172 -------EWEMHLKTKRT-----------------ALQQDRFWSDMSNGMQLGRELSGG------ 206

  Fly  1161 WQTQQSQQQQQVQWSSVGGLEAIKSAPVESVA-PT---TTTYYISASDLYPQQTETYTMLQPASN 1221
                  :....:|   ||.:.:..|.|...:: |:   |:..::...|..|...||       |.
  Rat   207 ------ELGDSIQ---VGTVFSEDSCPQTYISTPSTEDTSACHLRGKDFLPPLKET-------ST 255

  Fly  1222 ESYVIEQVNHQQQHCQQQIQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAP 1286
            |..::     |...|.:.:.::....||....:::.:........:.:.|:|   |.:|:..:..
  Rat   256 EENIL-----QLNQCVKPLTLTPDVSQRMCTLEKSVECSDCGKTFVNELELQ---AHSSSHSENN 312

  Fly  1287 LH-------IYNAATSNDVH----QMQHTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPG 1340
            ||       .:....|:|.|    :.::.:.::..:.:.|..|..:.       ||||.|
  Rat   313 LHKPEECGQAFTHPVSHDGHVIPTEKKYYECKKCEKFFTHPVYLNIH-------VQSHTV----- 365

  Fly  1341 ATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDL--HPAVAPFNCPHCPMAF 1403
                             .:|  ..|:.|  |..|:   |.|..|:.|  |.....:.|..|...|
  Rat   366 -----------------EKP--YDCKEC--GKAFT---ERSSLIVHLRQHTREKSYECKECGKTF 406

  Fly  1404 AGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFH--------------MTLKTDPSG 1454
            ...::.::|:.||...:.|||.||.:.|.:...|..|: |.|              .|..:...|
  Rat   407 IQPSRLTEHMRSHTGEKPYQCDQCGNAFASSSYLTTHL-RTHTGEKPFECNICGKAFTRSSYLLG 470

  Fly  1455 AVKVEDVQLQITSER----RPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQ--------QKALQQ 1507
            .::..      |.|:    :..|:.:..|..|..|         :::|..:        :||...
  Rat   471 HIRTH------TGEKPYECKVCGKAFSGRSWLTIH---------LRKHTGERPYPCTECEKAFTS 520

  Fly  1508 LPQAQHHQQQQQPQ------------LQQEVLQQVQQLQVQVQPQQHQ-------------QHQQ 1547
            ..|...|.:....:            .....|:...::...::|.:..             :|..
  Rat   521 FAQLTEHIKTHTGEKPFRCKVCARTFRNSSCLKTHFRIHTGIKPYKCNYCGKDFTARSGLTKHVL 585

  Fly  1548 VLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHS--------HANEQ-FE 1603
            :...::|.:                            |.:|....|..|        |..|: ||
  Rat   586 IHNGEKPYE----------------------------CKECGKAFSTSSGLVEHIRIHTGEKPFE 622

  Fly  1604 ELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQ----SEPDSTTTLRQYRKRGVIVGP 1664
            ..|..:|    |...|::|.           |:...:.|:    ::.|.|.|...|.:
  Rat   623 CYQCGKA----LAHSSSLVG-----------HLRTHTGEKPFECNQCDKTFTRSSYLR------- 665

  Fly  1665 QGPLHLATPVASPSPSSSPSSST-------VDHIPPASPATPASPAPPPSPAVASTVQVSELRTS 1722
               :|:.|..............|       ..||...:...|.. .........|..|::....:
  Rat   666 ---IHMRTHTGEKPYECKECGKTFPERSCLTKHIRTHTGERPYE-CKECGKGFISFAQLTVHIKT 726

  Fly  1723 H------HCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGR 1781
            |      .|..|.:.|.|..||:.|.::..|   ..||.|:.|.:.:..|:.|..|:.:|..| :
  Rat   727 HSSERPFQCKVCTKSFRNSSSLETHFRIHTG---VKPYKCSYCGKDFTARSGLTIHLRNHTGE-K 787

  Fly  1782 PYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCD 1845
            .|.|..|...|...|.|..| |..|...||..||.|||.|.:.|.|..|:|.| ||..:||..|.
  Rat   788 SYACQECGKAFSTSSGLIAH-IRSHKGEKPFECDHCGKAFASSSYLNVHLKIHTGEKPFQCTVCG 851

  Fly  1846 RTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            :||.....|..|.|||: |..::|..|..||:..:..|.||:.|
  Rat   852 KTFTCSSYLPVHMRTHTGEKPFQCIICGKSFLWSSYLRVHMRIH 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	8/24 (33%)
		C2H2 Zn finger	1396..1416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1814..1834	CDD:275368	10/19 (53%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	7/19 (37%)
Zfp26	NP_001102465.2	KRAB	104..162	CDD:214630	9/71 (13%)
		C2H2 Zn finger	288..308	CDD:275368	4/22 (18%)
		COG5048	338..751	CDD:227381	84/518 (16%)
		C2H2 Zn finger	343..363	CDD:275368	4/26 (15%)
		C2H2 Zn finger	371..391	CDD:275368	8/24 (33%)
		C2H2 Zn finger	399..419	CDD:275368	4/19 (21%)
		C2H2 Zn finger	427..447	CDD:275368	7/20 (35%)
		C2H2 Zn finger	455..475	CDD:275368	2/19 (11%)
		C2H2 Zn finger	483..503	CDD:275368	4/28 (14%)
		C2H2 Zn finger	511..531	CDD:275368	4/19 (21%)
		C2H2 Zn finger	539..559	CDD:275368	1/19 (5%)
		C2H2 Zn finger	567..587	CDD:275368	1/19 (5%)
		COG5048	591..>918	CDD:227381	89/364 (24%)
		C2H2 Zn finger	595..615	CDD:275368	4/19 (21%)
		C2H2 Zn finger	623..643	CDD:275368	6/34 (18%)
		C2H2 Zn finger	651..671	CDD:275368	5/29 (17%)
		C2H2 Zn finger	679..699	CDD:275368	3/19 (16%)
		C2H2 Zn finger	707..727	CDD:275368	2/19 (11%)
		C2H2 Zn finger	735..755	CDD:275368	7/19 (37%)
		C2H2 Zn finger	763..783	CDD:275368	5/19 (26%)
		C2H2 Zn finger	791..811	CDD:275368	7/20 (35%)
		C2H2 Zn finger	819..839	CDD:275368	10/19 (53%)
		C2H2 Zn finger	847..867	CDD:275368	7/19 (37%)
		C2H2 Zn finger	875..895	CDD:275368	7/19 (37%)
		C2H2 Zn finger	903..923	CDD:275368
		C2H2 Zn finger	931..947	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100