DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and CG8089

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_611014.1	Gene:	CG8089 / 36679	FlyBaseID:	FBgn0033993	Length:	624	Species:	Drosophila melanogaster

Alignment Length:	669	Identity:	114/669 - (17%)
Similarity:	181/669 - (27%)	Gaps:	301/669 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly  1380 YSRHIIDL-----HPAVAP--------------FNCPHCPMAFAGRTKRSQHILSHHVVQQY--- 1422
            |.|.:..|     |.|:.|              :.|.:.|.      |:.|.:..|....:|
  Fly   139 YRRSVSQLAGQEAHGALRPKIAALFLPGLRCDCYKCENLPW------KKLQDVEDHQKTHRYSDN 197

  Fly  1423 -QCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQ 1486
             .|..|...|..|.:|..||.|                    :.||.|             :.|:
  Fly   198 FHCQICYRRFYLQHSLTSHIIR--------------------KSTSSR-------------ELHE 229

  Fly  1487 LQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQV 1551
            .:..::|...|..|::|.|:.                  .|.:|:.:.|.|
  Fly   230 NKRYKRLLENQKSQEEKELEL------------------SLNKVEDILVPV-------------- 262

  Fly  1552 QQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLT 1616
             ....|...:.:|.||    :|...|:  .:..||.|..        |..|.
  Fly   263 -AEDLQSYFKDESKHP----IQKRKTS--SLSKCPSCAQ--------NYGFS------------- 299

  Fly  1617 PPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSS 1681
                           :|..:.|             ::..|:|         |:...|
  Fly   300 ---------------FSHQLHM-------------VKHRRER---------LYTNFP-------- 319

  Fly  1682 SPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAH 1746
                                                     .||.:|...|.....|:||.|...
  Fly   320 -----------------------------------------FHCSFCNRSFLTRKFLRKHQQRVR 343

  Fly  1747 --GALTTMPYVCTICKRGYRMRTALHRH----------------------------------MES 1775
              ..|...|:.|..|...:::::||..|                                  |:.
  Fly   344 TFSTLLYRPFKCPHCTWRFQLKSALDSHVLRIHERRKPCLICKLPTSRLCCSAHTSKECNRAMQK 408

  Fly  1776 HDVEGRPYE--------------CNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESA 1826
            :..:.||..              |.||..:|.|...|..|....||..:..||:.||..|.::..
  Fly   409 YRDKMRPLREPPKGGCRKQPTPVCKICNRKFTRKFFLEEHMNKAHLNKRNFTCEICGANFYSQGT 473

  Fly  1827 LKTHIKFHGELGY--QCDGCDRTFEYLKELRKHRRTHSEMFYKCKFCPSSFMRFTNFRAHMKTHL 1889
            ::||.|....|.:  ||:.||.|.:.....|:|          ||           .::|....:
  Fly   474 MQTHRKAVHLLVHTVQCEVCDLTIKSKGNYRRH----------CK-----------SQSHKDNLV 517

  Fly  1890 PLGVFRNEDAASKSPSNNNSHASSDKLENPATPIEETPLTPMSSGGHLY------------HSPD 1942
            ..|  :|.|....|.....:..:.:||:..|:....|.:|..:...|.|            .:|.
  Fly   518 KFG--KNNDKTKDSNRRKGARTTDEKLDIEASSSTNTCMTSANKSTHNYKKMGIKTKQTHLKTPC 580

  Fly  1943 EYPNSV-----ESCAGNSV 1956
            .....|     |:| |||:
  Fly   581 RSKKRVKIKICETC-GNSI 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	3/12 (25%)
		C2H2 Zn finger	1396..1416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1424..1445	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1725..1746	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/53 (11%)
		C2H2 Zn finger	1785..1806	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1814..1834	CDD:275368	7/19 (37%)
		zf-C2H2	1839..1861	CDD:278523	7/23 (30%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	3/19 (16%)
CG8089	NP_611014.1	C2H2 Zn finger	289..309	CDD:275368	7/68 (10%)
		C2H2 Zn finger	322..343	CDD:275368	7/20 (35%)
		C2H2 Zn finger	355..376	CDD:275368	5/20 (25%)
		C2H2 Zn finger	432..453	CDD:275368	7/20 (35%)
		C2H2 Zn finger	461..486	CDD:275368	8/24 (33%)
		C2H2 Zn finger	490..506	CDD:275368	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439968
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930