DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and CG18011

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_610559.1	Gene:	CG18011 / 36068	FlyBaseID:	FBgn0033491	Length:	985	Species:	Drosophila melanogaster

Alignment Length:	1176	Identity:	194/1176 - (16%)
Similarity:	362/1176 - (30%)	Gaps:	447/1176 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   866 NCAHIDEFLTPADY-------------ATLTEQESSVSSPPNPFEQ------------------- 898
            :|.|...|.|...|             .:|..:...:...|:|.:|
  Fly     9 SCLHCSVFSTKYQYQEIFDEFGIELGLQSLLSRHYQLEVSPDPQKQQLLCEVCVTNLIRLFDIDE 73

  Fly   899 --------SSVAEPKDEKPSATEDPFDNSNFTNELIGFQNDIPCFENIETPEEGQNLHLELTQFL 955
                    ...|:.||.|  |.|||                                 :.:|:.
  Fly    74 LEREREAAKDAAQGKDSK--AEEDP---------------------------------IIITEV- 102

  Fly   956 RDLQPSQSDPPAGEQVEKIEMETQPSTVQMDVQSNLPVQAADTQPQNESA---NHSPFES----P 1013
                  |:.|||.:..:| .:.::|.|..:.....:|.:....:.:|.:|   |.:|..|    |
  Fly   103 ------QATPPAAKPAKK-TVPSRPLTKVLRPVPIIPTREPSARIRNRAAAASNVTPDTSRSPEP 160

  Fly  1014 ISSPQVQSQIELQMEPQIETQMQPQIETRMQHDVLSVQSPQNHQPQVQS-----HDQSQMQHQIP 1073
            ..:|..:..:. :.||::.:::..|     :|..:.:|:..:.:..|..     .::|....|:.
  Fly   161 PETPSTEDAVS-KSEPKLVSKVADQ-----EHFSVLIQNILDEEEAVVEDETAVKEESSEAVQVT 219

  Fly  1074 PQIEP--QIEVQNQE--------------QNTLQLVPQAQHQVVPHVQLQSQLVPHVQTQGTTTT 1122
            .:.|.  ||.:.|.|              ::...:.|...:..|..:...|:||  .|.:.:.:.
  Fly   220 EETEAPGQIVILNSEAVTDTNPDENVYIYEHEDVMDPNLDNVKVKPISCSSRLV--AQAEESQSD 282

  Fly  1123 VTYEQIYQQHIVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQQQVQWSSVGGLEAIKSAP 1187
            ...::....::|.........|.:|.::|...:...:     .|.::...||.:|....::|...
  Fly   283 DDIDEGETSNVVLFNFVDIKEKDEVDNIPEYLATVVK-----TSFEKLTFQWCTVCKHCSLKCPT 342

  Fly  1188 VESVAPTTTTYYISASDLY-------------------------------------PQQTETYTM 1215
            .||:....:..:.|..|:|                                     |:...|::.
  Fly   343 FESLFSHLSKAHKSRRDVYECPIEGCNKELKGRKFLAMHLVLLHAPVAEIPIYGSCPECKLTFSN 407

  Fly  1216 LQPASNES--YVIEQVNHQQQHCQ---------QQIQMSQQQHQRQHQQQQAQQQQQPIMILIQQ 1269
            :...:..|  :||::....:.:|:         ::.....|.|..:|:.:..
  Fly   408 ILQYNKHSCAHVIKKKRGFRSYCEMCSLEFPSWKRFNFHSQFHLEKHRPRAC------------- 459

  Fly  1270 PEIQQPVASASNPQQAPLHIYNAATSNDVHQMQHTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHP 1334
                              .:.:.||:|            |.:.:||..|             ||.
  Fly   460 ------------------FVCDYATTN------------IDELFQHLNY-------------SHE 481

  Fly  1335 VLGMPGATSISTKVTPIPVTAARGRPLTLKCRFC------------HNGPRFS-SSLEYS----- 1381
            .:|                        ||.|..|            ||....: ||..||
  Fly   482 PVG------------------------TLFCDLCDRTFRDPSVFMEHNKSHANVSSTTYSCSECM 522

  Fly  1382 ----------RHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQ--YQCGQCSHVFPAQ 1434
                      .|:..:|.:|  .:|..|...||.....:.|:..|.::::  :.|..|..:..::
  Fly   523 ANFESRGRLNGHMRAMHGSV--ISCELCSREFATEATYNIHMKKHLIIEKDVHVCSTCGLLSDSR 585

  Fly  1435 KALDVHIQRFHMTLKTDPSGAVKVEDVQL-------QITSERRPRGRPYKPRLQLQQHQLQPQQK 1492
            :.|..|:.    ::||...|: |: ||:|       :..|..      :|.:..||.|:.....|
  Fly   586 ETLLAHVN----SVKTACFGS-KI-DVELLRDAYVCEYCSSY------FKEKDCLQAHRDSGVHK 638

  Fly  1493 LQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQ 1557
            ..|...|...|....:...:||            |:..|||:
  Fly   639 DGVFLCQPCGKEFPHMKLYRHH------------LRNYQQLR----------------------- 668

  Fly  1558 PLMQPQSPHPSTVEMQASPTTPRKILCCP----DCEDCTSGHSHANEQFEELQTLQAPPTVLTPP 1618
                             |.:|.|::..|.    |.|:||..:.:.|..:
  Fly   669 -----------------SDSTHRRLEICVYYMCDQENCTESYVNWNSLY---------------- 700

  Fly  1619 STIVSVPSPQPMVYSQHITMPSPEQSEPDSTTT--------LRQYRKRGVIVGPQGPLHLATPVA 1675
                        .:.:.....:.:|:|..|.:.        |::.|.:         :.|:..||
  Fly   701 ------------THKRRTHESASKQAEKSSKSAQEWVCQFCLKECRSK---------MSLSVHVA 744

  Fly  1676 SPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLY-----CEERF--- 1732
                    .|...|::              ..|...|:.:..:....||..:     |.|.|
  Fly   745 --------RSHNNDNV--------------TCPLCNSSYKSHDALAKHHAYWHEPIECPECFKIV 787

  Fly  1733 TNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQ 1797
            .|..:...|..:.|.  ....|.|::|::|:..::.:..|.:.|   |:.|.|..|.........
  Fly   788 KNRRNYDTHVNVVHS--NKKRYSCSVCQKGFYHKSEMEAHQKLH---GQSYSCEQCSFTTRNKKS 847

  Fly  1798 LTLHKITVHLLSKPHTCDECGKQFGTESALKTHI-KFHGELGYQC-----DGCDRTFEYLKELRK 1856
            |::|.:..|.......|:.|.|:||....||||: :.||: .|.|     .||.|||....:|..
  Fly   848 LSVHVLGQHYKRFAFECNVCKKRFGRSQGLKTHMQRAHGD-KYTCRDYFDGGCGRTFVNSSQLNV 911

  Fly  1857 H-RRTH 1861
            | |:.|
  Fly   912 HVRKIH 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	9/50 (18%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/28 (18%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/20 (45%)
		zf-C2H2	1839..1861	CDD:278523	10/27 (37%)
		C2H2 Zn finger	1841..1861	CDD:275368	9/25 (36%)
		C2H2 Zn finger	1868..1888	CDD:275368
CG18011	NP_610559.1	PRK14950	<98..>184	CDD:237864	18/94 (19%)
		C2H2 Zn finger	488..508	CDD:275368	4/19 (21%)
		C2H2 Zn finger	518..538	CDD:275368	1/19 (5%)
		C2H2 Zn finger	545..565	CDD:275368	5/19 (26%)
		C2H2 Zn finger	575..596	CDD:275371	4/24 (17%)
		SFP1	<682..747	CDD:227516	13/109 (12%)
		C2H2 Zn finger	754..775	CDD:275368	4/20 (20%)
		C2H2 Zn finger	780..801	CDD:275368	5/20 (25%)
		C2H2 Zn finger	809..829	CDD:275368	4/19 (21%)
		C2H2 Zn finger	864..885	CDD:275368	9/20 (45%)
		C2H2 Zn finger	891..917	CDD:275368	9/25 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439982
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030