DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and ZNF445

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_852466.1	Gene:	ZNF445 / 353274	HGNCID:	21018	Length:	1031	Species:	Homo sapiens

Alignment Length:	1106	Identity:	216/1106 - (19%)
Similarity:	341/1106 - (30%)	Gaps:	377/1106 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   949 LELTQFLRDLQPSQ-------SDPPAGEQVEKIEMETQPSTVQMDVQSNLPVQAADTQPQNESAN 1006
            |.|.||| .:.|.:       .:|.:||:...:..|.|........:...|.|:.|.......|.
Human    98 LVLEQFL-SILPGELRVWVQLHNPESGEEAVALLEELQRDLDGTSWRDPGPAQSPDVHWMGTGAL 161

  Fly  1007 HSPFESPISSP-QVQSQIELQMEPQIETQMQPQIETRMQHDVLSVQSPQNHQPQVQSHDQSQMQH 1070
            .|.....::|| :..|.:...:||..|      ||.|   |.|:.||         ....:||..
Human   162 RSAQIWSLASPLRSSSALGDHLEPPYE------IEAR---DFLAGQS---------DTPAAQMPA 208

  Fly  1071 QIPPQIEPQIEVQNQEQNTLQLVPQAQHQVVPHVQLQSQLVPHVQTQGTTT----TVTYEQ---- 1127
            ..|.:..|                  ..||.|...|.:||      |.|.|    .||:.|
Human   209 LFPREGCP------------------GDQVTPTRSLTAQL------QETMTFKDVEVTFSQDEWG 249

  Fly  1128 --------IYQQHIVQQTVQQSSNKMQVISLPSAGS--ETTRQWQTQQSQQQQQVQWSSVGGLEA 1182
                    :|:. ::.:..:..::.:...:.|:..|  |....|.......|.
Human   250 WLDSAQRNLYRD-VMLENYRNMASLVGPFTKPALISWLEAREPWGLNMQAAQP------------ 301

  Fly  1183 IKSAPVESVAPT-------TTTYYISASDLYPQQTETYTMLQPASNESYVI------EQVNHQQQ 1234
             |..||  .|||       |..:.::...|...:|...:...||::.|..|      :|.:.|:.
Human   302 -KGNPV--AAPTGDDLQSKTNKFILNQEPLEEAETLAVSSGCPATSVSEGIGLRESFQQKSRQKD 363

  Fly  1235 HCQQQIQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAATSNDVH 1299
            .|:..||:..::.:.....:..:..:                .|.||..... |:.....|....
Human   364 QCENPIQVRVKKEETNFSHRTGKDSE----------------VSGSNSLDLK-HVTYLRVSGRKE 411

  Fly  1300 QMQHTQRQQIRQQYQHQQYQRLQQPQQTRV--------------------------VQSHPVLGM 1338
            .::|...:..|....|..|::..:..:..:                          :.||...|.
Human   412 SLKHGCGKHFRMSSHHYDYKKYGKGLRHMIGGFSLHQRIHSGLKGNKKDVCGKDFSLSSHHQRGQ 476

  Fly  1339 PGAT-SISTKVTPIPVTAARGRPL-----------TLKCRFCHNGPRFSSSLEYSRHIIDLHPAV 1391
            ...| .:|.|.:....|.:....|           ..|||.|....|:||:.  :|| ..:|..|
Human   477 SLHTVGVSFKCSDCGRTFSHSSHLAYHQRLHTQEKAFKCRVCGKAFRWSSNC--ARH-EKIHTGV 538

  Fly  1392 APFNCPHCPMAF----AGRTKRSQHI-------------------LSHHVVQQ-----YQCGQCS 1428
            .|:.|..|..||    |.|..|..|.                   ..||:..|     :.|.||.
Human   539 KPYKCDLCEKAFRRLSAYRLHRETHAKKKFLELNQYRAALTYSSGFDHHLGDQSGEKLFDCSQCR 603

  Fly  1429 HVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKP---------RLQLQQ 1484
            ..|..:..:..| ||.|                    |.|     :|||.         |....:
Human   604 KSFHCKSYVLEH-QRIH--------------------TQE-----KPYKCTKCRKTFRWRSNFTR 642

  Fly  1485 H-QLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQV 1548
            | :|..::|...|  .:.::..:|.|...  |.|..|.:::..|.| |..:...:.:....||::
Human   643 HMRLHEEEKFYKQ--DECREGFRQSPDCS--QPQGAPAVEKTFLCQ-QCGKTFTRKKTLVDHQRI 702

  Fly  1549 LQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPT 1613
            ...::|.|                               |.||  |...|
Human   703 HTGEKPYQ-------------------------------CSDC--GKDFA--------------- 719

  Fly  1614 VLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPS 1678
                                                     ||...::       |.........
Human   720 -----------------------------------------YRSAFIV-------HKKKHAMKRK 736

  Fly  1679 PSSSPSSS--TVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKH 1741
            |...||.|  ||..:|.:|    .|...|                 :.|..|.:.|.|...|..|
Human   737 PEGGPSFSQDTVFQVPQSS----HSKEEP-----------------YKCSQCGKAFRNHSFLLIH 780

  Fly  1742 HQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYEC-------NICRVRFPRPSQLT 1799
            .::..|   ..||.|..|.:.:|..:.|:||...|.:: :.|:|       |:      .|..||
Human   781 QRVHTG---EKPYKCRECGKAFRWSSNLYRHQRIHSLQ-KQYDCHESEKTPNV------EPKILT 835

  Fly  1800 LHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS- 1862
                    ..|...|.||||.|..:..|..|...| ||..|:|:.|.::::....|..|:|.||
Human   836 --------GEKRFWCQECGKTFTRKRTLLDHKGIHSGEKRYKCNLCGKSYDRNYRLVNHQRIHST 892

  Fly  1863 EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDAASKSPSNNNSHASSDKLENPATPIEETP 1927
            |..:||::|...|:......:|.:.|.     |...|....|:.::|..:..:|:. ..|.||.|
Human   893 ERPFKCQWCGKEFIGRHTLSSHQRKHT-----RAAQAERSPPARSSSQDTKLRLQK-LKPSEEMP 951

  Fly  1928 L 1928
            |
Human   952 L 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1396..1416	CDD:275368	8/42 (19%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	5/27 (19%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	6/21 (29%)
		C2H2 Zn finger	1841..1861	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1868..1888	CDD:275368	4/19 (21%)
ZNF445	NP_852466.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		SCAN	51..155	CDD:128708	14/57 (25%)
		KRAB	234..292	CDD:214630	8/58 (14%)
		C2H2 Zn finger	415..451	CDD:275368	4/35 (11%)
		COG5048	<457..643	CDD:227381	45/214 (21%)
		C2H2 Zn finger	460..479	CDD:275368	3/18 (17%)
		C2H2 Zn finger	487..507	CDD:275368	2/19 (11%)
		C2H2 Zn finger	515..535	CDD:275368	8/22 (36%)
		C2H2 Zn finger	543..563	CDD:275368	7/19 (37%)
		COG5048	595..1031	CDD:227381	107/530 (20%)
		C2H2 Zn finger	599..619	CDD:275368	7/20 (35%)
		C2H2 Zn finger	627..647	CDD:275368	2/19 (11%)
		C2H2 Zn finger	683..703	CDD:275368	4/20 (20%)
		C2H2 Zn finger	711..731	CDD:275368	8/84 (10%)
		C2H2 Zn finger	764..784	CDD:275368	6/19 (32%)
		C2H2 Zn finger	792..812	CDD:275368	6/19 (32%)
		C2H2 Zn finger	842..862	CDD:275368	8/19 (42%)
		C2H2 Zn finger	870..890	CDD:275368	5/19 (26%)
		C2H2 Zn finger	898..918	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..939		6/32 (19%)
		C2H2 Zn finger	953..972	CDD:275368	216/1106 (20%)
		C2H2 Zn finger	980..1000	CDD:275368
		C2H2 Zn finger	1008..1028	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100