DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mld and zf30C

DIOPT Version :9

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:NP_477301.1 Gene:zf30C / 34292 FlyBaseID:FBgn0270924 Length:777 Species:Drosophila melanogaster


Alignment Length:825 Identity:154/825 - (18%)
Similarity:246/825 - (29%) Gaps:308/825 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  1341 ATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAG 1405
            ||.:..::|      ..|.| .|.|..|:..  ..|...|.:| :..|.....|.|.||...|..
  Fly    16 ATKLLVEIT------TDGIP-KLHCPVCNKA--LVSLAGYVKH-VKKHQPPGGFECRHCDARFCH 70

  Fly  1406 RTKRSQHILSHHVV---------QQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDV 1461
            ..:.:||....|.|         :.:.|.:|...:..|:|     .|.|...|.......:.|..
  Fly    71 EEELTQHAKDEHGVTGAVAGQERKPFVCEKCGAEYKYQEA-----YRRHCRTKCGEEKLPREESR 130

  Fly  1462 QLQ-------------ITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQH 1513
            .::             ::..||.|     |....|.....|.....:::|:..:|..:.......
  Fly   131 PMECKCCYTRFSSASNLSKHRRSR-----PDTCGQPEYDSPGSSDGMKKHKAFRKKDRNRDSDDE 190

  Fly  1514 HQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQP------------QSPH 1566
            ....::.:...:.:....:|:.::  :|..|:.     ....:.|..:|            |.|.
  Fly   191 DTTSEESEDSDDDIPLASRLKTKL--KQESQNS-----DSGDECPDFEPNNSEDDADASGFQLPP 248

  Fly  1567 PSTVEMQASPTTPRKILCCPDCED-----------CTSGHSHANEQ----------------FEE 1604
            |:.|:::|.           |.||           ..|....:||:                ||.
  Fly   249 PAMVKVEAF-----------DEEDFEYQDASMYVKTESTDIFSNEKDKLLDVLLNEGDGLKPFES 302

  Fly  1605 LQTLQ---------APPTVLTPPSTIVSV--------PSP----QPMVYSQHITMPSPEQSEPDS 1648
            |:..|         |.|.|......::.:        |.|    :|           |::..|  
  Fly   303 LKVEQGAGILDEIAAVPLVEVAEEDVLELRGHQMEKPPGPRKRGRP-----------PKEKIP-- 354

  Fly  1649 TTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVAST 1713
             ...|:||||.   .|:          ||||..             |..||...|......:...
  Fly   355 -VVKRKYRKRN---APR----------SPSPDD-------------SSGTPKRVAKISKKELKER 392

  Fly  1714 VQ-VSELRTSHHCLYCEE----RFTNEISLKKHHQL-------------AHGALTTMPYVCTICK 1760
            :: ::::..|..|.:|.:    |...|..|:..|:|             .|..|....:.|.||.
  Fly   393 LKMINKMEKSWKCPHCVKIYHIRKPYEKHLRDDHKLNEAEMKEIFKDVDVHAKLDEEVFKCPICS 457

  Fly  1761 RGYRMRTALHRHMESHDVEGR-----PYECNI------------------------CRVRFPRPS 1796
            :.|.:...|..||:.|..:|:     |..||:                        |........
  Fly   458 KIYLVEKRLVTHMKVHGEDGKLTFKCPCYCNLFFATKEQATEHARAQHKELLYCEKCDKYMTGHD 522

  Fly  1797 QLTLHKITVHLLSKPHT------CDECGKQF-----------------------------GTESA 1826
            .|..|:...|...:|.:      ||:|||:|                             .|...
  Fly   523 SLKNHERNFHSKKEPRSQQRNLICDKCGKKFTGRTSLSDHVRSDCGRLPLYGCSVCGKHLSTAGI 587

  Fly  1827 LKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHSEMF--YKCKFCPSSF------------- 1875
            ||||:..| .:..||||.|.:||:...:.:.|.:|....:  |||..||..:             
  Fly   588 LKTHMLLHKADTPYQCDKCGKTFKVKAQYKSHLKTRHTDYKPYKCHLCPKEYPYRESLLTHMTVH 652

  Fly  1876 ------------MRFT---NFRAHMKTH------LPL--------GVFRNEDAASKSPSNNNSHA 1911
                        .|||   |.:||.|.|      |||        ||.|.:......|.....:.
  Fly   653 TGIKRFLCNNCGKRFTCISNLQAHRKVHADTCGQLPLNAKATQYMGVQRGKLLMGAKPEAGMEYE 717

  Fly  1912 SSDKL-------------------ENPATPIEETPLTPMSSGGHL 1937
            .:..|                   .:.:.|:...||...|:  ||
  Fly   718 ETKTLIAQDVIDRDMPMAQELNFPSDGSAPLATVPLNYAST--HL 760

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
C2H2 Zn finger 1365..1388 CDD:275368 5/22 (23%)
C2H2 Zn finger 1396..1416 CDD:275368 6/19 (32%)
C2H2 Zn finger 1424..1445 CDD:275368 5/20 (25%)
C2H2 Zn finger 1725..1746 CDD:275368 7/37 (19%)
C2H2 Zn finger 1756..1776 CDD:275368 7/19 (37%)
C2H2 Zn finger 1785..1806 CDD:275368 5/44 (11%)
C2H2 Zn finger 1814..1834 CDD:275368 11/48 (23%)
zf-C2H2 1839..1861 CDD:278523 8/21 (38%)
C2H2 Zn finger 1841..1861 CDD:275368 6/19 (32%)
C2H2 Zn finger 1868..1888 CDD:275368 10/47 (21%)
zf30CNP_477301.1 C2H2 Zn finger 33..53 CDD:275368 5/22 (23%)
C2H2 Zn finger 61..82 CDD:275368 6/20 (30%)
C2H2 Zn finger 98..117 CDD:275368 6/23 (26%)
C2H2 Zn finger 134..152 CDD:275368 0/17 (0%)
C2H2 Zn finger 511..532 CDD:275370 3/20 (15%)
COG5048 <523..>672 CDD:227381 33/148 (22%)
C2H2 Zn finger 546..566 CDD:275368 6/19 (32%)
C2H2 Zn finger 575..595 CDD:275368 5/19 (26%)
C2H2 Zn finger 603..624 CDD:275368 7/20 (35%)
C2H2 Zn finger 632..652 CDD:275368 3/19 (16%)
C2H2 Zn finger 660..680 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439973
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.930

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