DRSC/TRiP Functional Genomics Resources

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Protein Alignment mld and ZNF850

DIOPT Version :9

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:NP_001180481.1 Gene:ZNF850 / 342892 HGNCID:27994 Length:1090 Species:Homo sapiens


Alignment Length:1067 Identity:229/1067 - (21%)
Similarity:338/1067 - (31%) Gaps:367/1067 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1124 TYEQIYQQHIVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQQQVQWSSVGGLE-AIKSAP 1187
            |.:....:.|.:.|..|.....:..||  .||.....|:.:...|.|.:.....  || ||.:  
Human    86 TKDSCLPKEIYEVTSSQWVRMEKCHSL--VGSSVRDDWECKGQFQHQDINQERY--LEKAIMT-- 144

  Fly  1188 VESVAPTTTTYYISAS-----------DLY--------------PQQTETYTMLQPASNESYVIE 1227
                ..||.|:.:..|           .||              .||.||:|     ..:.|..:
Human   145 ----YETTPTFCLQTSLTLHHRIHPGEKLYKSTECMAFKYGSELTQQQETHT-----GEKLYKCK 200

  Fly  1228 Q-----------VNHQQQH-------CQQQ----IQMSQQ-QHQ------RQHQQQQAQQQQQPI 1263
            :           |.||:.|       |::.    |..|.. |||      |.|:.|::.:..:|.
Human   201 ECGKAFHHFSYLVKHQRIHTGEKPCACKEYGKAFISGSHLIQHQKMYTDERPHECQESVKAFRPS 265

  Fly  1264 MILIQQ------------PEIQQPVASASNPQQ--------APLHIYNAATSNDV------HQMQ 1302
            ..|||.            .|..:...|.|...|        .|.|......|..|      ||..
Human   266 AHLIQHWRIHTGDKPYECKECGKSFTSGSTLNQHQQIHTGEKPYHCKQCGKSFTVGSTLIRHQQI 330

  Fly  1303 HTQRQQ----------------IRQQ------------------------YQHQQYQRLQQPQQT 1327
            ||..:.                ||.|                        .:||:....::|...
Human   331 HTGEKPYDCKECGKSFASGSALIRHQRIHTGEKPYDCKECGKSFTFHSALIRHQRIHTGEKPYDC 395

  Fly  1328 R------VVQSHPVLGMPGATSISTKVTPIPVTAARGRPLT-----------------LKCRFCH 1369
            :      ..:|    |:.|..:|.|...|...... |:..|                 ..|:.| 
Human   396 KECGKSFTFRS----GLIGHQAIHTGEKPYDCKEC-GKSFTAGSTLIQHQRIHTGEKPYDCKEC- 454

  Fly  1370 NGPRFSSS---LEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVF 1431
             |..|:|.   |::.|    :|....|:.|..|..:|..|:.|::|...|...:.|.|.:|...|
Human   455 -GKSFASGSALLQHQR----IHTGEKPYCCKECGKSFTFRSTRNRHQRIHTGEKPYNCKECGKSF 514

  Fly  1432 PAQKALDVHIQRFHMTLK-----------TDPSGAVKVEDVQLQITSER----RPRGRPYKPRLQ 1481
            .:..||..| ||.|...|           |..||.:..:.|.   |.|:    :..|:.:..|..
Human   515 ASGSALLQH-QRIHTGEKPYHCKECGKSFTFRSGLIGHQAVH---TGEKPYDCKECGKSFTSRSA 575

  Fly  1482 LQQHQ------------------------LQPQQ-------------------KLQVQQHQQ--- 1500
            |.|||                        ||.||                   :|::.||||   
Human   576 LIQHQRIHTGEKPYHCKECGKSFTVGSTLLQHQQIHTGEKPYDCKECGKAFRLRLRLTQHQQIHT 640

  Fly  1501 --QQKALQQLPQA--------QHHQ--QQQQPQ---------LQQEVLQQVQQLQVQVQPQ---- 1540
              :....|:..:|        |||:  ..::|.         .|:..|.|.:::....:|.    
Human   641 GEKPYQCQECGKAFVSVSGLTQHHRIHTGEKPYECPDCGKAFRQRTYLNQHRRIHTGEKPYECKE 705

  Fly  1541 ------------QHQ-------------------------QHQQVLQVQQP-----------QQQ 1557
                        |||                         ||||:...::|           ...
Human   706 CGKSFTFCSGLIQHQQNHTDEKPYDGKECGKSFTSHSTLIQHQQIHTGEKPYDCKECGKSFTSHS 770

  Fly  1558 PLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAP------PTVLT 1616
            .|:|.|..|           |..|:..|.:|....:.|| ...|.:.|.|.:.|      ....|
Human   771 TLIQHQQIH-----------TGEKLYDCKECGKSFTSHS-TLIQHQPLHTGEKPYHCKECGKSFT 823

  Fly  1617 PPSTIVSVPSPQPMVYSQHITMPSPEQ--------SEPDSTTTLRQYRKRGVIVGPQGPLHLATP 1673
            ..|.::           ||..:.:.|:        ....|.:||.::::   |...:.|.|    
Human   824 LRSALI-----------QHRPVHTGEKRYSCKECGKSFTSRSTLIEHQR---IHTGEKPYH---- 870

  Fly  1674 VASPSPSSSPSSSTVDH--IPPASPATPASPAPPPSPAVASTVQVSELRTS---HHCLYCEERFT 1733
            ......|.:..|:.:.|  |...................:...|...:.|.   :.|..|.:.|.
Human   871 CKECGKSFAFRSAIIQHRRIHTGEKPYDCKECGKAFRRRSKLTQHQRIHTGEKPYRCHECGKAFV 935

  Fly  1734 NEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQL 1798
            ....|.|||.:..|   ..||.|..|.:.:|.||.|..|...|..: |||||..|...|...|:|
Human   936 RFSGLTKHHSIHTG---EKPYECKTCGKSFRQRTHLTLHQRIHTGD-RPYECKECGKSFTCGSEL 996

  Fly  1799 TLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS 1862
            ..|:.| |...||:.|.||||.|...|.|..|.:.| ||..|||..|.:.|.|...|.:|:..|:
Human   997 IRHQRT-HTGEKPYDCKECGKAFRCPSQLSQHKRIHTGEKTYQCPECGKAFFYASGLSRHQSVHT 1060

  Fly  1863 -EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
             |..|:||.|..:|.:.|....|.:.|
Human  1061 GEKPYECKTCGKAFKQLTQLTRHQRIH 1087

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
C2H2 Zn finger 1365..1388 CDD:275368 7/25 (28%)
C2H2 Zn finger 1396..1416 CDD:275368 6/19 (32%)
C2H2 Zn finger 1424..1445 CDD:275368 8/20 (40%)
C2H2 Zn finger 1725..1746 CDD:275368 7/20 (35%)
C2H2 Zn finger 1756..1776 CDD:275368 7/19 (37%)
C2H2 Zn finger 1785..1806 CDD:275368 7/20 (35%)
C2H2 Zn finger 1814..1834 CDD:275368 9/19 (47%)
zf-C2H2 1839..1861 CDD:278523 8/21 (38%)
C2H2 Zn finger 1841..1861 CDD:275368 6/19 (32%)
C2H2 Zn finger 1868..1888 CDD:275368 6/19 (32%)
ZNF850NP_001180481.1 KRAB 7..67 CDD:214630
KRAB 7..46 CDD:279668
C2H2 Zn finger 199..219 CDD:275368 3/19 (16%)
C2H2 Zn finger 227..244 CDD:275368 4/16 (25%)
COG5048 243..659 CDD:227381 85/430 (20%)
C2H2 Zn finger 255..275 CDD:275368 5/19 (26%)
C2H2 Zn finger 283..303 CDD:275368 4/19 (21%)
zf-H2C2_2 296..319 CDD:290200 4/22 (18%)
C2H2 Zn finger 311..331 CDD:275368 4/19 (21%)
zf-H2C2_2 324..348 CDD:290200 4/23 (17%)
C2H2 Zn finger 339..359 CDD:275368 3/19 (16%)
zf-H2C2_2 351..375 CDD:290200 3/23 (13%)
C2H2 Zn finger 367..387 CDD:275368 2/19 (11%)
zf-H2C2_2 379..403 CDD:290200 3/23 (13%)
C2H2 Zn finger 395..415 CDD:275368 3/23 (13%)
C2H2 Zn finger 423..443 CDD:275368 2/20 (10%)
zf-H2C2_2 436..460 CDD:290200 4/25 (16%)
C2H2 Zn finger 451..471 CDD:275368 7/25 (28%)
zf-H2C2_2 463..487 CDD:290200 6/27 (22%)
C2H2 Zn finger 479..499 CDD:275368 6/19 (32%)
zf-H2C2_2 493..516 CDD:290200 6/22 (27%)
C2H2 Zn finger 507..527 CDD:275368 8/20 (40%)
zf-H2C2_2 519..543 CDD:290200 7/24 (29%)
COG5048 531..947 CDD:227381 78/448 (17%)
C2H2 Zn finger 535..555 CDD:275368 3/19 (16%)
C2H2 Zn finger 563..583 CDD:275368 6/19 (32%)
zf-H2C2_2 575..599 CDD:290200 4/23 (17%)
C2H2 Zn finger 591..611 CDD:275368 4/19 (21%)
C2H2 Zn finger 619..639 CDD:275368 5/19 (26%)
zf-H2C2_2 632..656 CDD:290200 6/23 (26%)
C2H2 Zn finger 647..667 CDD:275368 5/19 (26%)
zf-H2C2_2 660..684 CDD:290200 4/23 (17%)
C2H2 Zn finger 675..695 CDD:275368 3/19 (16%)
zf-H2C2_2 687..711 CDD:290200 3/23 (13%)
C2H2 Zn finger 703..723 CDD:275368 3/19 (16%)
C2H2 Zn finger 732..751 CDD:275368 4/18 (22%)
C2H2 Zn finger 759..779 CDD:275368 3/19 (16%)
C2H2 Zn finger 787..807 CDD:275368 5/20 (25%)
C2H2 Zn finger 815..835 CDD:275368 4/30 (13%)
C2H2 Zn finger 843..863 CDD:275368 3/22 (14%)
zf-H2C2_2 856..879 CDD:290200 5/29 (17%)
C2H2 Zn finger 871..891 CDD:275368 3/19 (16%)
C2H2 Zn finger 899..919 CDD:275368 1/19 (5%)
zf-H2C2_2 912..936 CDD:290200 5/23 (22%)
C2H2 Zn finger 927..947 CDD:275368 7/19 (37%)
C2H2 Zn finger 955..975 CDD:275368 7/19 (37%)
zf-H2C2_2 967..992 CDD:290200 10/25 (40%)
C2H2 Zn finger 983..1003 CDD:275368 7/20 (35%)
zf-H2C2_2 995..1020 CDD:290200 12/25 (48%)
C2H2 Zn finger 1011..1031 CDD:275368 9/19 (47%)
zf-H2C2_2 1024..1046 CDD:290200 9/21 (43%)
C2H2 Zn finger 1039..1059 CDD:275368 6/19 (32%)
zf-H2C2_2 1052..1076 CDD:290200 9/23 (39%)
C2H2 Zn finger 1067..1087 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24376
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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