DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and zgc:66472

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_956106.2	Gene:	zgc:66472 / 327494	ZFINID:	ZDB-GENE-030131-5705	Length:	556	Species:	Danio rerio

Alignment Length:	541	Identity:	103/541 - (19%)
Similarity:	187/541 - (34%)	Gaps:	136/541 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1451 DPSGA---VKVEDVQLQITSE------------RRPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQ 1500
            ||..|   ..:|.:.:..|||            |....|.:|....|:||    .:|.:    |:
Zfish     5 DPLSAKFRTLIERLMVATTSEIVKIFSKVLLETRVEITRSWKEIDLLKQH----LEKCE----QE 61

  Fly  1501 QQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQP------QQQPL 1559
            :::|:.:..::...::..:.:     :.|.:|.....:|:......:..:|.:.      :.:..
Zfish    62 KREAIIRAQRSDFKREDDEME-----VSQFKQSYNSDKPRASGSKARTGKVSKDRCVSVGKTKVT 121

  Fly  1560 MQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSV 1624
            .|...|..|..:::...|...|..|               .:|...:.:..||
Zfish   122 AQSSKPGSSGKKVKTQKTNSPKTKC---------------TEFVARRKVGRPP------------ 159

  Fly  1625 PSPQPMVYSQH---ITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSS 1686
            ...:.|..|.|   ||:...:..:.|.                          ||.|.....:|.
Zfish   160 KKQKSMSISSHTIPITVDDDDDDDDDE--------------------------ASASVDFQTTSP 198

  Fly  1687 TVDHIPPASPATPASPAPPPSPAVASTVQVSE-LRTSHHCLYCEERFTNEIS--LKKHHQLAHGA 1748
            .|..:...:  ..::|..|....|:..::..: |....|||.|.....|:.|  .|..||:
Zfish   199 KVKEMKKEN--VTSTPTHPNDANVSRGLRDRQHLGMQRHCLCCSSDECNKQSSPSKAQHQV---- 257

  Fly  1749 LTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHT 1813
              ...|:|..|:|  |.:|.|  ..:||.. ..|..|:.|...|.....|..|:..|   ..|.:
Zfish   258 --PTVYICRKCER--RFKTDL--QFKSHKC-SMPQNCDKCGQVFNTLQGLFTHRQEV---QPPLS 312

  Fly  1814 CDECGKQFGTESALKTHIKFHGELGYQCDGCDRTFEYLKELRKHRRTHSEMFYKCKFCPS-SFMR 1877
            |.:|.::|.|..|...|.|.|..|....:...:.|    |:|..|.:.|::  :...|.| |:::
Zfish   313 CSQCEEKFATLCAWAVHKKIHTNLIIPKEIKSKRF----EVRLERISDSQL--EAALCSSGSYLQ 371

  Fly  1878 FTNFRAHMKTHLPLGVFRNEDAAS-KSPSNNNSHASSDKLENPATPIEETPLTPMSSGGHLYHSP 1941
            ..:.:            :|.|..: .:...||..|.....|:....:.::.:|.:||     .|.
Zfish   372 NNSSK------------QNSDVQNVNATETNNGSACERGAESTMENLPDSSMTQLSS-----QSS 419

  Fly  1942 DEYPNSVESCAGNSVALESYA 1962
            .|  :.::|..|.|...:.||
Zfish   420 AE--SLLDSSGGQSSVRKVYA 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368
		C2H2 Zn finger	1396..1416	CDD:275368
		C2H2 Zn finger	1424..1445	CDD:275368
		C2H2 Zn finger	1725..1746	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1814..1834	CDD:275368	7/19 (37%)
		zf-C2H2	1839..1861	CDD:278523	4/21 (19%)
		C2H2 Zn finger	1841..1861	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1868..1888	CDD:275368	3/20 (15%)
zgc:66472	NP_956106.2	C2H2 Zn finger	263..282	CDD:275368	8/23 (35%)
		C2H2 Zn finger	287..304	CDD:275368	4/16 (25%)
		C2H2 Zn finger	313..333	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595412
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930