DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and CG8944

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster

Alignment Length:	285	Identity:	62/285 - (21%)
Similarity:	100/285 - (35%)	Gaps:	94/285 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1689 DHIPPASPATPASPAPPPSPAVASTVQVSELRT---------SHHCLYCEERFTNEISLKKHHQL 1744
            |.|||...|        ..|.:..|::..:|..         .::|..|..:|.|......|.||
  Fly   469 DDIPPFKCA--------HCPEIVQTLRELDLHMLTHQPSLGGGYYCNICSIQFHNAQEFDNHKQL 525

  Fly  1745 AHGALTTMPYVCTICKRGYRMRTALHRHMESHD-------------------------VEG---- 1780
            ..|.:|.:.:.|.:|...:|.:.....|:..|:                         |||
  Fly   526 HLGGVTEIKFNCELCTASFREKANYDEHLRRHNEELFLPSLALNHSIMEGGLGDDEIGVEGEESR 590

  Fly  1781 -----------------------------------------RPYECNICRVRFPRPSQLTLHKIT 1804
                                                     :||.|::||..|..|..|..|:|
  Fly   591 GSGSRRKRRHAAKATDDMVDDDDRIGGGGGGGSGGGGTDIAKPYGCDVCRRSFATPGHLNAHRI- 654

  Fly  1805 VHL--LSKPHTCD--ECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHSEM 1864
            ||.  ..:.:.||  :|.|.|...::|..|:|.| ....::||.|.:||:..|.|:.|::.|.::
  Fly   655 VHQDERERCYKCDYPQCNKSFVARNSLFEHLKQHYSNEEFKCDICGKTFKSTKNLQNHKQIHDKI 719

  Fly  1865 -FYKCKFCPSSFMRFTNFRAHMKTH 1888
             .|.|:.|.|:|.:......|.:.|
  Fly   720 KRYVCQICGSAFAQAAGLYLHKRRH 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368
		C2H2 Zn finger	1396..1416	CDD:275368
		C2H2 Zn finger	1424..1445	CDD:275368
		C2H2 Zn finger	1725..1746	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/21 (38%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510
		MADF	379..472	CDD:214738	1/2 (50%)
		C2H2 Zn finger	476..496	CDD:275368	4/27 (15%)
		C2H2 Zn finger	506..526	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	4/19 (21%)
		C2H2 Zn finger	636..656	CDD:275368	8/20 (40%)
		zf-C2H2_8	639..712	CDD:292531	25/73 (34%)
		C2H2 Zn finger	666..688	CDD:275368	8/21 (38%)
		zf-C2H2	694..716	CDD:278523	8/21 (38%)
		C2H2 Zn finger	696..716	CDD:275368	8/19 (42%)
		zf-H2C2_2	708..733	CDD:290200	8/24 (33%)
		C2H2 Zn finger	724..744	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439972
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930