DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp112

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001100957.1	Gene:	Zfp112 / 308420	RGDID:	1305757	Length:	893	Species:	Rattus norvegicus

Alignment Length:	764	Identity:	137/764 - (17%)
Similarity:	229/764 - (29%)	Gaps:	272/764 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1162 QTQQSQQQQQVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVI 1226
            |:.|....:||.:..        |..|...:|..|     ....:|..|         |.:..:.
  Rat   311 QSPQRAHMEQVPYKC--------SENVHHGSPLNT-----CGCAHPGNT---------SQKCSIP 353

  Fly  1227 EQVNHQQQHCQQQIQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYN 1291
            ||......|.::..:....:....|::......|...:.:.::...::.:...:..::...|..|
  Rat   354 EQAVGSCSHRKRTFRAHSGEEPNNHEENGNVLNQSLCLQVNRKISAEEKLCQGAECRKDFTHCSN 418

  Fly  1292 AATSNDVHQMQ---------------HTQR-QQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGM-- 1338
            ..:.:.||..:               |.|. ..:|.|.|...........||..:|.|..|.:
  Rat   419 LNSPHRVHVEETLCNPDCGNHFSLPPHFQDFPAVRPQGQPHNRTCCTSFGQTLCLQGHQKLHIRE 483

  Fly  1339 -----PGATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPH 1398
                 .|....:...||....    :.:..||..|..|.....:|:..:.|   |....||.|..
  Rat   484 KPFRKEGGNGCNWGSTPKDCE----KQMLHKCSACGKGFSHRRALQVHQRI---HTGEKPFKCGE 541

  Fly  1399 CPMAFAGRTKRSQHILSHHVV----QQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVE 1459
            |...|:    ||.::.:|..|    :.|:||:|...|.....|..| ||.|
  Rat   542 CGKGFS----RSAYLQAHQRVHTGEKPYKCGECGKGFSRSAYLQGH-QRVH-------------- 587

  Fly  1460 DVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQ---QQQPQ 1521
                  |.|     :|||                    .::..|...:....|.||:   .::|.
  Rat   588 ------TGE-----KPYK--------------------CEECGKGFSRSSHLQGHQRVHTGEKPY 621

  Fly  1522 LQQEVLQQVQ---QLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKIL 1583
            ..:|..:...   .||:         ||:|...::|.:
  Rat   622 KCEECGKGFSWSFNLQI---------HQRVHTGEKPYK--------------------------- 650

  Fly  1584 CCPDCEDCTSGHSHANE--QFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEP 1646
                |.:|..|.|.|:.  ..|.:.|.:.|
  Rat   651 ----CGECGKGFSKASTLLAHERIHTGEKP----------------------------------- 676

  Fly  1647 DSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVA 1711

  Rat   677 ----------------------------------------------------------------- 676

  Fly  1712 STVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESH 1776
                       :.|..|.:.|:.:..|:.|..:..|   ..||:|.:|.:|:..|..|..|...|
  Rat   677 -----------YQCHECGKNFSQKSYLQSHQSVHSG---ERPYICEVCGKGFSQRAYLQGHQRVH 727

  Fly  1777 DVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFHGE-LGYQ 1840
            .:. :||.|.:|...|.:.|:|..|: .||...||:.|:.|.|.|...:.|:.|.:.|.| ..|:
  Rat   728 TLV-KPYNCEVCGKGFSQGSRLEAHR-RVHAGGKPYKCETCAKGFSESAGLQAHQRIHAEGRAYK 790

  Fly  1841 CDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            |:.|.:.|.....|:.|:|.|: |..|||:.|...|.:.:|.:||.:.|
  Rat   791 CELCGKGFSGYSGLQAHQRVHTGEKPYKCEVCGKDFSQRSNLQAHQRVH 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	5/22 (23%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	6/19 (32%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	6/19 (32%)
Zfp112	NP_001100957.1	KRAB	2..62	CDD:214630
		KRAB	2..41	CDD:279668
		C2H2 Zn finger	463..480	CDD:275368	4/16 (25%)
		COG5048	508..852	CDD:227381	104/541 (19%)
		C2H2 Zn finger	511..531	CDD:275368	5/22 (23%)
		zf-H2C2_2	523..548	CDD:290200	8/31 (26%)
		C2H2 Zn finger	539..559	CDD:275368	6/23 (26%)
		zf-H2C2_2	551..576	CDD:290200	7/24 (29%)
		C2H2 Zn finger	567..587	CDD:275368	8/20 (40%)
		zf-H2C2_2	579..604	CDD:290200	11/70 (16%)
		C2H2 Zn finger	595..615	CDD:275368	4/19 (21%)
		zf-H2C2_2	607..631	CDD:290200	5/23 (22%)
		C2H2 Zn finger	623..643	CDD:275368	5/28 (18%)
		zf-H2C2_2	635..659	CDD:290200	9/63 (14%)
		C2H2 Zn finger	651..671	CDD:275368	6/19 (32%)
		zf-H2C2_2	664..688	CDD:290200	6/134 (4%)
		C2H2 Zn finger	679..699	CDD:275368	5/19 (26%)
		C2H2 Zn finger	707..727	CDD:275368	6/19 (32%)
		C2H2 Zn finger	735..755	CDD:275368	6/20 (30%)
		C2H2 Zn finger	763..783	CDD:275368	6/19 (32%)
		C2H2 Zn finger	791..811	CDD:275368	6/19 (32%)
		zf-H2C2_2	804..828	CDD:290200	10/23 (43%)
		C2H2 Zn finger	819..839	CDD:275368	6/19 (32%)
		zf-H2C2_2	831..854	CDD:290200	4/9 (44%)
		C2H2 Zn finger	847..867	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100