DRSC/TRiP Functional Genomics Resources

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Protein Alignment mld and Zfp473

DIOPT Version :9

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:XP_006229247.1 Gene:Zfp473 / 292884 RGDID:1305084 Length:967 Species:Rattus norvegicus


Alignment Length:1133 Identity:231/1133 - (20%)
Similarity:355/1133 - (31%) Gaps:327/1133 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   940 TPEEGQNLHLELTQFLRDL---------QP--SQSDPPAGEQVEKIEMETQPSTV-QMDVQSNL- 991
            |.|:.::|..||.|  |||         |.  |.:.||            |||.: |.||:..| 
  Rat    33 TLEDWEDLESELGQ--RDLFWDATLNNYQDLFSFTHPP------------QPSLIFQPDVREELE 83

  Fly   992 ------PVQAAD--TQPQNESANHSPFESPISS-PQVQSQIELQMEPQIETQMQPQI----ETRM 1043
                  |...:|  |:.:|........|..:|. .::.|..||..|..|........    |:..
  Rat    84 AIVRGGPEATSDEATEAKNPPLQSGFLEEDLSQIMEIFSTEELNFESCIGENWFDSFLGDPESLP 148

  Fly  1044 QHDVLSVQSPQNHQPQVQSHDQSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQHQVVPHVQLQS 1108
            :.|:.:.:||.:.    :.|:........||....:..|.:..       |:.....|...:.:|
  Rat   149 RPDISNKESPTDR----RCHESESGLSPGPPHCTREGAVMSDS-------PEKNLDPVILKESRS 202

  Fly  1109 QLVPHVQTQGTTTTVTYEQIYQ-----------QHIVQQTVQQSSNKMQVISLPSAGSETTRQWQ 1162
            .|......||      .|::|:           .|::|..|..:..:     ||:        ||
  Rat   203 DLSQQDSVQG------QEKLYKCSECGKSFSQSYHLIQHWVIHARGE-----LPA--------WQ 248

  Fly  1163 TQQSQQQQQVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVIE 1227
            .|..               |:....:..:.|.|.|                      |:||||. 
  Rat   249 EQPG---------------ALSKGALLLMQPGTQT----------------------SSESYVC- 275

  Fly  1228 QVNHQQQHCQQQI--QMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIY 1290
                  |.|.:..  .|..|.||:.|..::        :...|...:::|....|:.....| :.
  Rat   276 ------QECGKSFSQNMYLQWHQKIHTGEK--------LCKTQSDNLEKPSKGPSDEPGKQL-VS 325

  Fly  1291 NAATSNDV-------HQMQHTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKV 1348
            .||.|..:       .:...|.::..|:.....||     .....|:...|:.....||      
  Rat   326 EAADSAKLCDSRGWDQEKPPTNKRHDREDLHKGQY-----GDSPSVLHPKPIKHQKTAT------ 379

  Fly  1349 TPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAP---FNCPHCPMAFAGRTKRS 1410
                      |....:||.|  |..||    ::.|:.| |..|..   :.|..||..|..|....
  Rat   380 ----------RAKCFRCRRC--GKTFS----WAFHLAD-HQKVHTQRLYGCTSCPAVFNLRKHFF 427

  Fly  1411 QHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRP 1475
            ||..:|.....::|.:|..:|..:.:|..| |..|                    |.|     :|
  Rat   428 QHRKTHFAKTVFECQECRKLFNRRSSLIKH-QAVH--------------------TGE-----KP 466

  Fly  1476 YKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQ---QQQPQLQQEVLQQVQQLQVQV 1537
            ||                    ..:..||.......:.||:   .::|....|..:...:.....
  Rat   467 YK--------------------CNECGKAFNHFSTLKIHQRIHSGEKPYTCSECGKTFSRRTALT 511

  Fly  1538 QPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGH------- 1595
                  :|.:|....:|.|.|:...:...||.:..........::..|..|:: |.||       
  Rat   512 ------EHHRVHSGFRPHQCPVCPRRFSRPSHLTRHQLSHAAERLFGCAKCKE-TFGHKEQLERH 569

  Fly  1596 --SH----------ANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHIT----------- 1637
              ||          ..|.|....||....::....:|...|...    :|||..           
  Rat   570 YKSHTIECSYECKQCGEHFICSSTLNCHLSIHIRENTSEKVSGQ----HSQHTEKCFKNTKCGKA 630

  Fly  1638 ---MPSPEQSEP--DSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPA 1697
               ...|||.|.  ....:..|...|........|:|..:..|:..|:..............|..
  Rat   631 FNHSKYPEQHEKIHAKVASCEQSPCRNTCDQSMQPIHCQSSCAAVKPNKCTEPEKCIRNTSVSQH 695

  Fly  1698 TPASPAPPPSPAVASTVQVSELRTSHH-------------------------------------- 1724
            .|:...||......:.........|:|                                      
  Rat   696 QPSQSEPPFKCNTCNRTFKQSAHLSNHQLIHTTEKPFKCKECDRAFKHSNYLIQHQKIHSVKDFE 760

  Fly  1725 CLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICR 1789
            |..|.::|..:..|.||.::..|   ..|:.|..|.:.:.....|.||...|..| :||.|..|.
  Rat   761 CSECGKKFHQKSCLSKHQKIHSG---QKPFKCADCGKAFIFSAQLIRHQRIHTGE-KPYVCQECG 821

  Fly  1790 VRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKE 1853
            ..|.:.|.|||| :..|...||:||..|||.|..::..:.|.:.| ||....||.|.::|.:...
  Rat   822 KAFSQSSCLTLH-LRTHTGEKPYTCSTCGKAFSQKANQRKHERTHSGEKPCACDVCGKSFGFSTH 885

  Fly  1854 LRKHRRTHSEMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDAASKSPSNNNSHASSDKLEN 1918
            ||:|:|.|::...:|:.|..:|..|:....|.|.|       ...|||.:       |.|..|..
  Rat   886 LRQHQRIHTKEKPRCQDCHKAFHSFSALSEHQKLH-------TCTAASTT-------AQSHLLTA 936

  Fly  1919 PATPIEETPLTPMSSGGHLYHSPDEYPN 1946
            .|...|...|.|......|..||...||
  Rat   937 EARASEGPHLEPAIETSTLQTSPPHSPN 964

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
C2H2 Zn finger 1365..1388 CDD:275368 8/22 (36%)
C2H2 Zn finger 1396..1416 CDD:275368 7/19 (37%)
C2H2 Zn finger 1424..1445 CDD:275368 6/20 (30%)
C2H2 Zn finger 1725..1746 CDD:275368 6/20 (30%)
C2H2 Zn finger 1756..1776 CDD:275368 5/19 (26%)
C2H2 Zn finger 1785..1806 CDD:275368 8/20 (40%)
C2H2 Zn finger 1814..1834 CDD:275368 6/19 (32%)
zf-C2H2 1839..1861 CDD:278523 8/21 (38%)
C2H2 Zn finger 1841..1861 CDD:275368 8/19 (42%)
C2H2 Zn finger 1868..1888 CDD:275368 6/19 (32%)
Zfp473XP_006229247.1 KRAB 23..83 CDD:214630 19/63 (30%)
KRAB_A-box 23..63 CDD:143639 10/31 (32%)
C2H2 Zn finger 219..239 CDD:275368 3/19 (16%)
C2H2 Zn finger 275..295 CDD:275368 6/26 (23%)
C2H2 Zn finger 386..406 CDD:275370 9/26 (35%)
C2H2 Zn finger 413..433 CDD:275368 7/19 (37%)
C2H2 Zn finger 441..461 CDD:275368 6/20 (30%)
zf-H2C2_2 453..478 CDD:290200 11/70 (16%)
COG5048 465..916 CDD:227381 99/486 (20%)
C2H2 Zn finger 469..489 CDD:275368 4/19 (21%)
zf-H2C2_2 482..506 CDD:290200 4/23 (17%)
C2H2 Zn finger 497..517 CDD:275368 2/25 (8%)
C2H2 Zn finger 525..545 CDD:275368 3/19 (16%)
C2H2 Zn finger 553..573 CDD:275368 5/20 (25%)
C2H2 Zn finger 581..601 CDD:275368 4/19 (21%)
C2H2 Zn finger 624..644 CDD:275368 4/19 (21%)
C2H2 Zn finger 680..699 CDD:275370 2/18 (11%)
C2H2 Zn finger 706..726 CDD:275368 2/19 (11%)
zf-H2C2_2 718..743 CDD:290200 2/24 (8%)
C2H2 Zn finger 734..754 CDD:275368 0/19 (0%)
C2H2 Zn finger 761..781 CDD:275368 6/19 (32%)
zf-H2C2_2 774..796 CDD:290200 7/24 (29%)
C2H2 Zn finger 789..809 CDD:275368 5/19 (26%)
zf-H2C2_2 802..826 CDD:290200 10/24 (42%)
C2H2 Zn finger 817..837 CDD:275368 8/20 (40%)
zf-H2C2_2 830..854 CDD:290200 13/24 (54%)
C2H2 Zn finger 845..865 CDD:275368 6/19 (32%)
C2H2 Zn finger 873..893 CDD:275368 8/19 (42%)
C2H2 Zn finger 900..920 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166335907
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24376
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.030

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