DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and Zfp606

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_038956593.1	Gene:	Zfp606 / 292610	RGDID:	1309810	Length:	787	Species:	Rattus norvegicus

Alignment Length:	1081	Identity:	197/1081 - (18%)
Similarity:	325/1081 - (30%)	Gaps:	398/1081 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   879 YATLTEQ-ESSVSSPPNPFEQSSVAEPKDEKPSATEDPFDNSNFTNELIGFQNDIPCFENIETPE 942
            :.||.:| :.|||....|.:.:...|...|:.....|....:. ..|.:.|::....|    |.|
  Rat    10 WGTLMDQSDPSVSWALCPQDPAWHIEGSPEESRRQADGLQTAQ-DQEPVTFKDVAVAF----TQE 69

  Fly   943 EGQNLHLELTQFLRD--LQPSQSDPPAGEQVEKIEM-----ETQPSTVQM------------DVQ 988
            |.:.|.|......||  |:........|.|:.|.|:     :.:|.:::.            :|:
  Rat    70 EWEQLDLVQRTLYRDVMLETYGHLLSVGNQIAKPEVISLLEQEEPWSLEQGYPKSSCPEWMRNVE 134

  Fly   989 SNLPVQAADTQPQNESANHSPFESPI-SSPQVQSQIELQMEPQIET-QMQPQIETR----MQHDV 1047
            |...:.|.....:.:|:|....|..| .:|.:.....|....|||. .|......|    ||..|
  Rat   135 SKALIPAQSVFEEEQSSNGMVLERYIWDNPWLSRLGVLGYGDQIEMYHMNQNAGMREMVFMQKQV 199

  Fly  1048 LSVQSPQNHQPQVQSHDQSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQHQVVPHVQLQSQLVP 1112
            ||.:..:..:   ...:.||..:.||||...|:|                     |.....   .
  Rat   200 LSQRGSEFCK---LGTEYSQSLNLIPPQRVSQLE---------------------HFYKSD---T 237

  Fly  1113 HVQTQGTTTTVTY-EQIYQQHIVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQQQVQWSS 1176
            |::|....:.:.| :::..::|
  Rat   238 HLETWRCNSAIMYADKVTCENI------------------------------------------- 259

  Fly  1177 VGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTET----YTMLQPASNESYVIEQVNHQQQHCQ 1237
                 ..:.|..:||.|           :||.:.:|    :.......:.:::|:..:|:..|..
  Rat   260 -----DYEKAFCQSVQP-----------VYPAKLQTRDNMFKCTDAVKSFNHIIQFGDHKAVHTG 308

  Fly  1238 QQIQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAATSNDVHQMQ 1302
            :::...::.||..:|...          ||:.|..|    ...|..:......|....:..  |:
  Rat   309 EKLYGYKEYHQIFNQSPS----------LIEHPRFQ----IGGNQYEKYKEYGNIFYFSSF--ME 357

  Fly  1303 HTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLG----MPGATSISTKVTPIPVTAARGRPLTL 1363
            |.....:.:.|::.::::              |.|    :...||..|...|....
  Rat   358 HQNIGGVEKAYKYNEWEK--------------VFGYDSLLAQHTSTYTAEKPYEFN--------- 399

  Fly  1364 KCRFCHNGPRFSSSLEYSRHIID---LHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCG 1425
            ||         .:|..:|.::|.   .||...|:.|..|...|..|:..::|..:|..::.|:|.
  Rat   400 KC---------GTSFIWSSYLIQHKKTHPGDKPYECDKCRKVFRNRSALTKHERTHTGIKPYECN 455

  Fly  1426 QCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSER----RPRGRPYKPRLQLQQHQ 1486
            :|...|.....|.|| .|.|                    |.|:    ...|:.:.....|..||
  Rat   456 KCGKAFSWNSHLIVH-TRIH--------------------TGEKPYVCNECGKSFNWNSHLIGHQ 499

  Fly  1487 LQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQV 1551
                                                                    :.|
  Rat   500 --------------------------------------------------------RTH------ 502

  Fly  1552 QQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLT 1616
                                      |..|...|.:|....|..||
  Rat   503 --------------------------TGEKPFECTECGKSFSWSSH------------------- 522

  Fly  1617 PPSTIVSVPSPQPMVYSQHITMPSPEQSEP----DSTTTLRQYRKRGVIVGPQGPLHLATPVASP 1677
                :::           |:.|.:.|  :|    :.....|.|
  Rat   523 ----LIA-----------HMRMHTGE--KPFKCDECEKAFRDY---------------------- 548

  Fly  1678 SPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHH 1742
                   |:...|....|.|.|                       :.|..|.:.|:     ...|
  Rat   549 -------SALSKHERTHSGAKP-----------------------YKCTECGKSFS-----WSSH 578

  Fly  1743 QLAHGALTT--MPYVCTICKRGYRMRTALHRHMESHDVEG-RPYECNICRVRFPRPSQLTLHKIT 1804
            .:||....|  .||.|..|.:.:|.|:||.:|...|  .| :|||||.|.....:.:.|..|:.|
  Rat   579 LIAHQRTHTGEKPYNCQECGKAFRERSALTKHEIIH--SGIKPYECNKCGKSCSQMAHLVRHQRT 641

  Fly  1805 VHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYK 1867
             |...||:.|::|||.|.....|..|.:.| ||..|:|:.|:|:|.....|..|||||: |..|:
  Rat   642 -HTGEKPYECNKCGKSFSQSCHLVAHRRIHTGEKPYKCNQCERSFNCSSHLIAHRRTHTGEKPYR 705

  Fly  1868 CKFCPSSFMRFTNFRAHMKTHL---PLGVFRNEDAASKSPS 1905
            |..|..:|...::...|::.|.   |......|.|..|:.|
  Rat   706 CNECGKAFNESSSLIVHLRNHTGEKPYKCIHCEKAFCKNSS 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	4/25 (16%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1756..1776	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	7/19 (37%)
		zf-C2H2	1839..1861	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1841..1861	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1868..1888	CDD:275368	4/19 (21%)
Zfp606	XP_038956593.1	KRAB	57..116	CDD:214630	15/62 (24%)
		COG5048	386..785	CDD:227381	115/584 (20%)
		C2H2 Zn finger	399..418	CDD:275368	5/36 (14%)
		C2H2 Zn finger	426..446	CDD:275368	5/19 (26%)
		C2H2 Zn finger	454..474	CDD:275368	7/20 (35%)
		C2H2 Zn finger	482..502	CDD:275368	4/75 (5%)
		C2H2 Zn finger	510..530	CDD:275368	6/53 (11%)
		C2H2 Zn finger	538..558	CDD:275368	4/48 (8%)
		C2H2 Zn finger	566..586	CDD:275368	6/24 (25%)
		C2H2 Zn finger	594..614	CDD:275368	7/19 (37%)
		C2H2 Zn finger	622..642	CDD:275368	6/20 (30%)
		C2H2 Zn finger	650..670	CDD:275368	7/19 (37%)
		C2H2 Zn finger	678..698	CDD:275368	8/19 (42%)
		C2H2 Zn finger	706..726	CDD:275368	4/19 (21%)
		C2H2 Zn finger	734..754	CDD:275368	4/13 (31%)
		C2H2 Zn finger	762..782	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100