DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and ZNF841

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001356754.1	Gene:	ZNF841 / 284371	HGNCID:	27611	Length:	925	Species:	Homo sapiens

Alignment Length:	1025	Identity:	206/1025 - (20%)
Similarity:	343/1025 - (33%)	Gaps:	245/1025 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   955 LRDLQPSQSDPPAGEQVEKIEMETQPS--TVQM---DVQSNLPVQAADTQPQNESANHSPFESPI 1014
            :::|.|.|:. ..||:.:.:.:|...|  |...   :::.||  |..|.|.::...|:.  |.|:
Human    99 IKELPPIQNS-NTGEKFQAVMLEGHESYDTENFYFREIRKNL--QEVDFQWKDGEINYK--EGPM 158

  Fly  1015 S-SPQVQSQIELQMEPQIETQ-MQPQIETRMQHDVLSVQSPQNHQPQVQSHDQSQMQHQIPPQIE 1077
            : ...:..|.....:..:|.: |:.|:..|.|..:..:|                 :.|...:|.
Human   159 THKNNLTGQRVRHSQGDVENKHMENQLILRFQSGLGELQ-----------------KFQTAEKIY 206

  Fly  1078 PQIEVQNQEQNTLQLVPQAQHQVVPHVQLQSQLVPHVQTQGTTTTVTYEQIYQQHIVQQTVQQSS 1142
            ...:::....|.....|           || ::.|.|||       ...:.|....:|.::....
Human   207 GCNQIERTVNNCFLASP-----------LQ-RIFPGVQT-------NISRKYGNDFLQLSLPTQD 252

  Fly  1143 NKMQVISLPSAGSETTRQWQTQQSQQQQQVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYP 1207
            .|..:...|..|:|..:.::...|....|:..::.......:|..........|.:.|..:...|
Human   253 EKTHIREKPYIGNECGKAFRVSSSLINHQMIHTTEKPYRCNESGKAFHRGSLLTVHQIVHTRGKP 317

  Fly  1208 QQTETYTMLQPASNESYVIEQVNHQQQH-------CQQ-QIQMSQQQHQRQHQQQQAQQQQQPIM 1264
            .|.:....:...::     :.|||::.|       |.: ....|:..|...||:
Human   318 YQCDVCGRIFRQNS-----DLVNHRRSHTGDKPYICNECGKSFSKSSHLAVHQR----------- 366

  Fly  1265 ILIQQPEIQQPVASASNPQQAPL--HIYNAATSNDVHQMQHTQRQQIRQQYQHQQYQRLQQPQQT 1327
                       :.:...|.:...  ..::.::|...||..||..:..:.....:.::|
Human   367 -----------IHTGEKPYKCNRCGKCFSQSSSLATHQTVHTGDKPYKCNECGKTFKR------- 413

  Fly  1328 RVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVA 1392
                             ::.:|...:..|..:|.|  |..|  |..|..:.:..||.| :|....
Human   414 -----------------NSSLTAHHIIHAGKKPYT--CDVC--GKVFYQNSQLVRHQI-IHTGET 456

  Fly  1393 PFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVK 1457
            |:.|..|...|..|::.:.|...|...:.|:|.:|..||.....|.|| ||.|
Human   457 PYKCNECGKVFFQRSRLAGHRRIHTGEKPYKCNECGKVFSQHSHLAVH-QRVH------------ 508

  Fly  1458 VEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQL 1522
                    |.|     :|||                           ..:..:|
Human   509 --------TGE-----KPYK---------------------------CNECGKA----------- 522

  Fly  1523 QQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPD 1587
                ......|.|         ||::...::|.:..:......:...:.:.....|..|.|.|..
Human   523 ----FNWGSLLTV---------HQRIHTGEKPYKCNVCGKVFNYGGYLSVHMRCHTGEKPLHCNK 574

  Fly  1588 C------EDCTSGHS--HANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQS 1644
            |      ..|.:.|.  |..|:..:......           |.:.|....::.:..|...|.|.
Human   575 CGMVFTYYSCLARHQRMHTGEKPYKCNVCGK-----------VFIDSGNLSIHRRSHTGEKPFQC 628

  Fly  1645 EP-----DSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAP 1704
            ..     ...:.|.::||   |...:.|........:.:..||.:...|.|       |..:|..
Human   629 NECGKVFSYYSCLARHRK---IHTGEKPYKCNDCGKAYTQRSSLTKHLVIH-------TGENPYH 683

  Fly  1705 PPSPAVASTVQVSEL---------RTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICK 1760
            ......| .:|.|:|         ...|.|..|...|:::.|| .:||..|..  .|||.|..|.
Human   684 CNEFGEA-FIQSSKLARYHRNPTGEKPHKCSECGRTFSHKTSL-VYHQRRHTG--EMPYKCIECG 744

  Fly  1761 RGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTES 1825
            :.:...|.|.||...|..| :||:||.|...|...|.|..| .::|...||:.|:||||.|...|
Human   745 KVFNSTTTLARHRRIHTGE-KPYKCNECGKVFRYRSGLARH-WSIHTGEKPYKCNECGKAFRVRS 807

  Fly  1826 ALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            .|..|...| ||..|:|:.|.:.|.....|..|:|.|: |..|||..|..:|.|.:....|.:.|
Human   808 ILLNHQMMHTGEKPYKCNECGKAFIERSNLVYHQRNHTGEKPYKCMECGKAFGRRSCLTKHQRIH 872

  Fly  1889 LPLGVFR-NEDAASK-SPSNNNSHASSDKLENPATPIE-ETPLTPMSSGG 1935
            .....:: ||...|. |.|....|......||..|.:. |.||..:.:.|
Human   873 SSEKPYKCNECGKSYISRSGLTKHQIKHAGENLTTKLNVERPLDVVLTSG 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	7/22 (32%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	9/20 (45%)
		C2H2 Zn finger	1725..1746	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
ZNF841	NP_001356754.1	KRAB	8..69	CDD:214630
		COG5048	260..636	CDD:227381	81/519 (16%)
		C2H2 Zn finger	265..284	CDD:275368	3/18 (17%)
		C2H2 Zn finger	292..312	CDD:275368	3/19 (16%)
		C2H2 Zn finger	320..340	CDD:275368	3/24 (13%)
		C2H2 Zn finger	348..368	CDD:275368	5/41 (12%)
		C2H2 Zn finger	376..396	CDD:275368	3/19 (16%)
		C2H2 Zn finger	404..424	CDD:275368	2/43 (5%)
		C2H2 Zn finger	432..452	CDD:275368	7/22 (32%)
		C2H2 Zn finger	460..480	CDD:275368	5/19 (26%)
		COG5048	484..886	CDD:227381	114/505 (23%)
		C2H2 Zn finger	488..508	CDD:275368	9/20 (45%)
		C2H2 Zn finger	516..536	CDD:275368	5/43 (12%)
		C2H2 Zn finger	544..564	CDD:275368	0/19 (0%)
		C2H2 Zn finger	572..592	CDD:275368	4/19 (21%)
		C2H2 Zn finger	600..620	CDD:275368	2/30 (7%)
		C2H2 Zn finger	628..648	CDD:275368	3/22 (14%)
		C2H2 Zn finger	656..676	CDD:275368	3/19 (16%)
		C2H2 Zn finger	712..732	CDD:275368	7/20 (35%)
		C2H2 Zn finger	740..760	CDD:275368	6/19 (32%)
		C2H2 Zn finger	768..788	CDD:275368	7/20 (35%)
		C2H2 Zn finger	796..816	CDD:275368	9/19 (47%)
		C2H2 Zn finger	824..844	CDD:275368	6/19 (32%)
		C2H2 Zn finger	852..872	CDD:275368	5/19 (26%)
		C2H2 Zn finger	880..900	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100