DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and ZNF615

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001308252.1	Gene:	ZNF615 / 284370	HGNCID:	24740	Length:	747	Species:	Homo sapiens

Alignment Length:	785	Identity:	157/785 - (20%)
Similarity:	254/785 - (32%)	Gaps:	254/785 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1157 TTRQWQ---TQQSQQQQQVQWSSVGGLEAI---KSAP-----VESVAPTTTTYYISASDLYPQQT 1210
            |..:||   ..|....:.|...:...|.|:   .|.|     :|....|.||           :.
Human    23 TWEEWQFLSPAQKDLYRDVMLENYSNLVAVGYQASKPDALSKLERGEETCTT-----------ED 76

  Fly  1211 ETYTML----QPASNESYV-IEQVNHQQQH--CQQQIQMSQQQHQRQHQQQQAQQQQQPIMILIQ 1268
            |.|:.:    ..||..:|. |.:::...||  ..|.||.|.:|...|:.......|.:...:|.|
Human    77 EIYSRICSDSGGASGGAYAEIRKIDDPLQHHLQNQSIQKSVKQCHEQNMFGNIVNQNKGHFLLKQ 141

  Fly  1269 QPEI----QQPVAS--ASNPQQAPLHIYNAATSN-DVHQMQHTQRQQIRQQYQHQQYQRLQQP-- 1324
            ..:.    ::|:.|  :...|:....:.|:|..| |...:.|...:|.   |...::..:.:|
Human   142 DCDTFDLHEKPLKSNLSFENQKRSSGLKNSAEFNRDGKSLFHANHKQF---YTEMKFPAIAKPIN 203

  Fly  1325 -------QQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRF---SSSLE 1379
                   |:|..:::..|                             |..|  |..|   |..::
Human   204 KSQFIKQQRTHNIENAHV-----------------------------CSEC--GKAFLKLSQFID 237

  Fly  1380 YSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRF 1444
            :.|    :|....|..|..|..||:.:::...|..:|..::.|:|.:|...|..:..|::| |:.
Human   238 HQR----VHTGEKPHVCSMCGKAFSRKSRLMDHQRTHTELKHYECTECDKTFLKKSQLNIH-QKT 297

  Fly  1445 HMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLP 1509
            ||                         .|:||                    ...|..||..:..
Human   298 HM-------------------------GGKPY--------------------TCSQCGKAFIKKC 317

  Fly  1510 QAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQA 1574
            :..:||:..                                          ..:.||..:|..:|
Human   318 RLIYHQRTH------------------------------------------TGEKPHGCSVCGKA 340

  Fly  1575 SPT-----------TPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQ 1628
            ..|           |..|...|.:|          .:.|.|.:.|.|.....|         ..:
Human   341 FSTKFSLTTHQKTHTGEKPYICSEC----------GKGFIEKRRLTAHHRTHT---------GEK 386

  Fly  1629 PMVYS---QHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDH 1690
            |.:.:   :..|:.:...:...:.|..:.|                      :.|......::.|
Human   387 PFICNKCGKGFTLKNSLITHQQTHTGEKLY----------------------TCSECGKGFSMKH 429

  Fly  1691 IPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYV 1755
            .......|.....|                  :.|..|.:.|..:..|.:|.:...|   ..|||
Human   430 CLMVHQRTHTGEKP------------------YKCNECGKGFALKSPLIRHQRTHTG---EKPYV 473

  Fly  1756 CTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQ 1820
            ||.|::|:.|::.|..|..:|..| :||.||.|...|...|:|.:|:.| |...||:.|.||||.
Human   474 CTECRKGFTMKSDLIVHQRTHTAE-KPYICNDCGKGFTVKSRLIVHQRT-HTGEKPYVCGECGKG 536

  Fly  1821 FGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRA 1883
            |..:..|..|.:.| ||..|.|:.|.:.|.....|..|||||: |..|.|..|.......:...|
Human   537 FPAKIRLMGHQRTHTGEKPYICNECGKGFTEKSHLNVHRRTHTGEKPYVCSECGKGLTGKSMLIA 601

  Fly  1884 HMKTH 1888
            |.:||
Human   602 HQRTH 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/25 (24%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	4/19 (21%)
ZNF615	NP_001308252.1	KRAB	13..73	CDD:214630	11/49 (22%)
		KRAB	13..52	CDD:279668	6/28 (21%)
		COG5048	<100..430	CDD:227381	75/496 (15%)
		C2H2 Zn finger	222..242	CDD:275368	6/25 (24%)
		zf-H2C2_2	238..259	CDD:290200	7/24 (29%)
		C2H2 Zn finger	250..270	CDD:275368	5/19 (26%)
		C2H2 Zn finger	278..298	CDD:275368	6/20 (30%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		COG5048	330..734	CDD:227381	82/341 (24%)
		C2H2 Zn finger	334..354	CDD:275368	3/19 (16%)
		C2H2 Zn finger	362..382	CDD:275368	6/29 (21%)
		C2H2 Zn finger	390..410	CDD:275368	1/19 (5%)
		C2H2 Zn finger	418..438	CDD:275368	2/19 (11%)
		zf-H2C2_2	431..454	CDD:290200	4/40 (10%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		zf-H2C2_2	459..482	CDD:290200	10/25 (40%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
		C2H2 Zn finger	502..522	CDD:275368	8/20 (40%)
		C2H2 Zn finger	530..550	CDD:275368	8/19 (42%)
		C2H2 Zn finger	558..578	CDD:275368	7/19 (37%)
		zf-H2C2_2	570..591	CDD:290200	10/20 (50%)
		C2H2 Zn finger	586..606	CDD:275368	4/19 (21%)
		C2H2 Zn finger	614..634	CDD:275368
		zf-H2C2_2	627..649	CDD:290200
		C2H2 Zn finger	642..662	CDD:275368
		C2H2 Zn finger	670..690	CDD:275368
		zf-H2C2_2	682..707	CDD:290200
		C2H2 Zn finger	698..718	CDD:275368
		C2H2 Zn finger	726..746	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100