DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and ZNF544

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001374339.1	Gene:	ZNF544 / 27300	HGNCID:	16759	Length:	769	Species:	Homo sapiens

Alignment Length:	975	Identity:	177/975 - (18%)
Similarity:	308/975 - (31%)	Gaps:	324/975 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   934 CFENIE---TPEEGQNLHLELTQFLRDLQPSQSDPPAGEQVEKIEMETQPSTVQM-------DVQ 988
            |||::.   |.||.:.|.|......|:                :.:||....|.:       ||.
Human    69 CFEDVAMAFTQEEWEQLDLAQRTLYRE----------------VTLETWEHIVSLGLFLSKSDVI 117

  Fly   989 SNLPVQAADTQPQNESANHSPFESPISSPQVQSQIELQMEPQIETQMQPQIETRMQHDVLSVQSP 1053
            |.|        .|.|....:..|:|........:..|..|       :.:....:.|.|...:|.
Human   118 SQL--------EQEEDLCRAEQEAPRDWKATLEENRLNSE-------KDRAREELSHHVEVYRSG 167

  Fly  1054 QNHQPQV---QSHDQSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQHQVV---PHVQLQ---SQ 1109
            ....|.:   :..|||.             :::..::|:|:.:.....::.   .|.:|:   ..
Human   168 PEEPPSLVLGKVQDQSN-------------QLREHQENSLRFMVLTSERLFAQREHCELELGGGY 219

  Fly  1110 LVPHVQTQGTTTTVTYEQIYQQHIVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQ--QQV 1172
            .:|...:...||..|.....:.:...:.::|:|   ..|:....|:: .:..::.|..:.  |.:
Human   220 SLPSTLSLLPTTLPTSTGFPKPNSQVKELKQNS---AFINHEKNGAD-GKHCESHQCARAFCQSI 280

  Fly  1173 QWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVIEQVNHQQQHCQ 1237
            ..|.:|.:|..|..|.|.:....:..|.|:...:.:   |:::.:....:.|     .:...|
Human   281 YLSKLGNVETGKKNPYEYIVSGDSLNYGSSLCFHGR---TFSVKKSDDCKDY-----GNLFSH-- 335

  Fly  1238 QQIQMSQQQ--H--QRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYN------- 1291
             .:.:::|:  |  :.|::..:.::.....:.|:|        ...|.|.:.|.....
Human   336 -SVSLNEQKPVHFGKSQYECDECRETCSESLCLVQ--------TERSGPGETPFRCEERCAAFPM 391

  Fly  1292 AATSNDVHQMQHTQRQQIRQQ---------YQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTK 1347
            |::.:|.:.:|.|::..:..|         ..||:....::|
Human   392 ASSFSDCNIIQTTEKPSVCNQCGKSFSCCKLIHQRTHTGEKP----------------------- 433

  Fly  1348 VTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQH 1412
                           .:|..|  |..||.|.:...| ...|....|:.|..|..:|..|:|...|
Human   434 ---------------FECTQC--GKSFSQSYDLVIH-QRTHTGEKPYECDLCGKSFTQRSKLITH 480

  Fly  1413 ILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLK---TDPSGAVKVEDVQLQITSERRPRG- 1473
            ...|...:.|||.:|...|.....|.|| ||.|...|   ....|....:..:| :|.:|...|
Human   481 QRIHTGEKPYQCIECRKSFRWNSNLIVH-QRIHTGEKPYECTHCGKSFSQSYEL-VTHKRTHTGE 543

  Fly  1474 RPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQ 1538
            :|:|    ..|......||..:..||:....          ::..:..|..:...|..:|..
Human   544 KPFK----CTQCGKSFSQKYDLVVHQRTHTG----------EKPYECNLCGKSFSQSSKLIT--- 591

  Fly  1539 PQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFE 1603
                  ||::...::|.|                            |.:|......:|:
Human   592 ------HQRIHTGEKPYQ----------------------------CIECGKSFRWNSN------ 616

  Fly  1604 ELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPL 1668
                                      :|..|.|
Human   617 --------------------------LVIHQRI-------------------------------- 623

  Fly  1669 HLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFT 1733
                                 |       |...|                    :.|.:|.:.|:
Human   624 ---------------------H-------TGEKP--------------------YDCTHCGKSFS 640

  Fly  1734 NEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQL 1798
            ....|..|.:...|   ..||.|..|.:.:...|.|.||::.|..| :||:||.|...|.|.|.|
Human   641 QSYQLVAHKRTHTG---EKPYECNECGKAFNRSTQLIRHLQIHTGE-KPYKCNQCNKAFARSSYL 701

  Fly  1799 TLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS 1862
            .:|:.| |...||..|.:|||.|...|.|.:|.:.| ||..|:|..|.::|....:|..|||||:
Human   702 VMHQRT-HTGEKPFECSQCGKAFSGSSNLLSHHRIHSGEKPYECSDCGKSFRQQSQLVVHRRTHT 765

Fly 1863 1862
Human 766 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	7/22 (32%)
		C2H2 Zn finger	1396..1416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1424..1445	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	9/20 (45%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368
ZNF544	NP_001374339.1	KRAB	68..127	CDD:214630	18/81 (22%)
		C2H2 Zn finger	410..428	CDD:275368	3/17 (18%)
		zf-H2C2_2	424..445	CDD:404364	7/60 (12%)
		C2H2 Zn finger	436..456	CDD:275368	7/22 (32%)
		COG5048	460..>753	CDD:227381	93/462 (20%)
		C2H2 Zn finger	464..484	CDD:275368	6/19 (32%)
		C2H2 Zn finger	492..512	CDD:275368	8/20 (40%)
		C2H2 Zn finger	520..540	CDD:275368	4/20 (20%)
		C2H2 Zn finger	548..568	CDD:275368	5/19 (26%)
		C2H2 Zn finger	576..596	CDD:275368	5/28 (18%)
		C2H2 Zn finger	604..624	CDD:275368	6/104 (6%)
		C2H2 Zn finger	632..652	CDD:275368	5/19 (26%)
		C2H2 Zn finger	660..680	CDD:275368	6/19 (32%)
		C2H2 Zn finger	688..708	CDD:275368	9/20 (45%)
		C2H2 Zn finger	716..736	CDD:275368	8/19 (42%)
		C2H2 Zn finger	744..764	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100