DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp759

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_006517316.1	Gene:	Zfp759 / 268670	MGIID:	2446280	Length:	747	Species:	Mus musculus

Alignment Length:	583	Identity:	131/583 - (22%)
Similarity:	205/583 - (35%)	Gaps:	157/583 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1364 KCRFCHNGPRFSSSL-EYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQC 1427
            ||..|.|..|..||| |:.|    :|....|:.|..|..||...::.|:|...|.....|:|..|
Mouse   273 KCEVCGNFLRSRSSLHEHKR----MHAGEKPYKCEVCGKAFEYPSRLSKHKNIHTGETPYKCKVC 333

  Fly  1428 SHVFPAQKALDVH--IQRFHMTLKTDPSG-AVKVEDV---------------------------Q 1462
            ...|.:..:|.||  |.|.....|.:..| |.:...|                           .
Mouse   334 GKAFRSPSSLRVHKGIHREDKPYKCEVCGKAFRYSSVLSDHKNIHTGETPYKCKVCGKAFRSPSS 398

  Fly  1463 LQITSERRPRGRPYK----------PRLQLQQHQL----QPQQKLQVQQHQQQQKALQQLPQAQH 1513
            |::.......|:|||          |.: |..|:.    :...|.:|........:...|.:..|
Mouse   399 LRVHKGTHRGGKPYKCEVCGKAFHYPSI-LSNHKNIHTGETPYKCKVCGKAFHSPSSLILHKGTH 462

  Fly  1514 HQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTT 1578
            .:.:   ..:.||..:..:     .|.....|:::.:.|:|.:..:.:.....||::..|....|
Mouse   463 REDK---PYKCEVCGKAFR-----YPSILSNHKKIHREQKPSKCKVGRKVFWSPSSLPEQKRIHT 519

  Fly  1579 PRKILCCP-DCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPE 1642
            ..|    | :||.|.....:                    ||.::           :|..:.:.|
Mouse   520 REK----PYNCEICGKAFKY--------------------PSRLL-----------KHKIIHTRE 549

  Fly  1643 QSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPS 1707
                      :||:.:  :.|..    ..||           ||...|
Mouse   550 ----------KQYKCK--VCGNA----FCTP-----------SSLWQH----------------- 570

  Fly  1708 PAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRH 1772
                ..:...||...  |..|.:.|... ||...|:::|  ....||.|.||....|.:::||.|
Mouse   571 ----KRIHTGELPCK--CDVCGKTFRFP-SLLLKHKISH--TDQKPYKCKICGNFLRSQSSLHEH 626

  Fly  1773 MESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFHGE- 1836
            ...|..| :||:|.||...|..||:|:.|. .:|....|:.|..|||.|.:.|:|:.|...|.|
Mouse   627 KRMHAGE-KPYKCEICGKAFEYPSRLSKHN-NIHTGETPYKCKVCGKAFRSPSSLRVHKGIHRED 689

  Fly  1837 LGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNED 1898
            ..::|:.|.:.|.|...|..|:..|: |..||||.|..:      ||.....|:..|:.|.::
Mouse   690 KPFKCEVCGKAFRYSSVLSDHKNIHTGETPYKCKVCGKA------FRTTSSLHIHKGIHREDN 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	9/23 (39%)
		C2H2 Zn finger	1396..1416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1424..1445	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	6/21 (29%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
Zfp759	XP_006517316.1	KRAB	31..89	CDD:214630
		C2H2 Zn finger	134..154	CDD:275368
		COG5048	158..547	CDD:227381	62/321 (19%)
		C2H2 Zn finger	165..182	CDD:275368
		C2H2 Zn finger	190..210	CDD:275368
		C2H2 Zn finger	218..238	CDD:275368
		C2H2 Zn finger	246..266	CDD:275368
		C2H2 Zn finger	274..294	CDD:275368	9/23 (39%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		C2H2 Zn finger	358..378	CDD:275368	3/19 (16%)
		C2H2 Zn finger	386..406	CDD:275368	1/19 (5%)
		COG5048	410..>742	CDD:227381	96/436 (22%)
		C2H2 Zn finger	414..434	CDD:275368	3/20 (15%)
		C2H2 Zn finger	442..462	CDD:275368	2/19 (11%)
		C2H2 Zn finger	470..490	CDD:275368	4/24 (17%)
		C2H2 Zn finger	498..514	CDD:275370	2/15 (13%)
		C2H2 Zn finger	526..546	CDD:275368	6/50 (12%)
		C2H2 Zn finger	554..574	CDD:275368	6/57 (11%)
		C2H2 Zn finger	582..602	CDD:275368	6/20 (30%)
		C2H2 Zn finger	610..630	CDD:275368	7/19 (37%)
		C2H2 Zn finger	638..658	CDD:275368	8/20 (40%)
		C2H2 Zn finger	666..686	CDD:275368	8/19 (42%)
		C2H2 Zn finger	694..714	CDD:275368	6/19 (32%)
		C2H2 Zn finger	722..742	CDD:275368	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100