DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and ZNF473

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001006657.1	Gene:	ZNF473 / 25888	HGNCID:	23239	Length:	871	Species:	Homo sapiens

Alignment Length:	845	Identity:	169/845 - (20%)
Similarity:	269/845 - (31%)	Gaps:	258/845 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1129 YQQHIVQQTVQQSSNKMQVISLP---SAGSETTRQWQTQQSQQQQQVQWSSVGGLEAIKSAPVES 1190
            |..|..|.:||:.....|.....   |.....|:.|.| .::::..|......|.:...|.   |
Human   193 YSDHSQQDSVQEGEKPYQCSECGKSFSGSYRLTQHWIT-HTREKPTVHQECEQGFDRNASL---S 253

  Fly  1191 VAPTTTT---YYI---------SASDLYPQQTETYTM--------------LQPASNE------- 1222
            |.|.|.|   :|:         .::.|:.|:|.|...              .||..::
Human   254 VYPKTHTGYKFYVCNEYGTTFSQSTYLWHQKTHTGEKPCKSQDSDHPPSHDTQPGEHQKTHTDSK 318

  Fly  1223 SY-----------VIEQVNHQQQH---------CQQQIQMSQQ--QHQRQHQQQQAQQQQQ---- 1261
            ||           :.....||:.|         ||....:.:.  |||:.|..:...:.|:
Human   319 SYNCNECGKAFTRIFHLTRHQKIHTRKRYECSKCQATFNLRKHLIQHQKTHAAKTTSECQECGKI 383

  Fly  1262 --PIMILIQQPEIQQPVASASNP----QQAPLHIYNAATSNDVHQMQHTQRQQIRQQYQHQQYQR 1320
              ...:||:    .|.:.:...|    ::.....:|:...  :||..|:..:..:.....:.:.|
Human   384 FRHSSLLIE----HQALHAGEEPYKCNERGKSFRHNSTLK--IHQRVHSGEKPYKCSECGKAFHR 442

  Fly  1321 LQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHII 1385
            .....:.|              .|.|...|            .||:.|...  ||......||..
Human   443 HTHLNEHR--------------RIHTGYRP------------HKCQECVRS--FSRPSHLMRHQA 479

  Fly  1386 DLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKT 1450
             :|.|..|::|..|...|:...:..||...|.|...|:|.:|...|.....|..| :..|...|.
Human   480 -IHTAEKPYSCAECKETFSDNNRLVQHQKMHTVKTPYECQECGERFICGSTLKCH-ESVHAREKQ 542

  Fly  1451 D--PSGAVKVEDVQLQITSERRPR-------GRPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQ 1506
            .  .||.:      |....|::.:       .:.:.....|.||:....:.::..:..|..||..
Human   543 GFFVSGKI------LDQNPEQKEKCFKCNKCEKTFSCSKYLTQHERIHTRGVKPFECDQCGKAFG 601

  Fly  1507 QLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVE 1571
            |..:..|||                           :.|.:|...:..:|...:.    ..|.::
Human   602 QSTRLIHHQ---------------------------RIHSRVRLYKWGEQGKAIS----SASLIK 635

  Fly  1572 MQASPTT--PRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQ 1634
            :|:..|.  |.|      |.:|....||:..                               .|:
Human   636 LQSFHTKEHPFK------CNECGKTFSHSAH-------------------------------LSK 663

  Fly  1635 HITMPSPEQ----SEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPAS 1695
            |..:.:.|.    |:.|...|.|.|                               .|.|
Human   664 HQLIHAGENPFKCSKCDRVFTQRNY-------------------------------LVQH----- 692

  Fly  1696 PATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICK 1760
            ..|.|...|..                  |..|.:.|.....|.||.::..|   ..||||..|.
Human   693 ERTHARKKPLV------------------CNECGKTFRQSSCLSKHQRIHSG---EKPYVCDYCG 736

  Fly  1761 RGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTES 1825
            :.:.:...|.||...|..| :||.|..|...|.:.|.|::|: .||...||:.|.||||.|..::
Human   737 KAFGLSAELVRHQRIHTGE-KPYVCQECGKAFTQSSCLSIHR-RVHTGEKPYRCGECGKAFAQKA 799

  Fly  1826 ALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            .|..|.:.| ||..|.|:.|.:.|.....|.:|.|.|: |..|:|:.|..:|...::...|.:.|
Human   800 NLTQHQRIHTGEKPYSCNVCGKAFVLSAHLNQHLRVHTQETLYQCQRCQKAFRCHSSLSRHQRVH 864

Fly 1889 1888
Human 865 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	4/19 (21%)
ZNF473	NP_001006657.1	KRAB_A-box	6..45	CDD:143639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..81
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..164
		COG5048	207..614	CDD:227381	84/479 (18%)
		C2H2 Zn finger	211..231	CDD:275368	4/20 (20%)
		C2H2 Zn finger	239..259	CDD:275368	5/22 (23%)
		C2H2 Zn finger	267..286	CDD:275368	2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..318		2/27 (7%)
		Interaction with SLBP/pre-mRNA complex	312..552		52/281 (19%)
		C2H2 Zn finger	322..342	CDD:275368	2/19 (11%)
		C2H2 Zn finger	349..369	CDD:275368	5/19 (26%)
		C2H2 Zn finger	377..397	CDD:275368	4/23 (17%)
		C2H2 Zn finger	405..425	CDD:275368	3/21 (14%)
		C2H2 Zn finger	433..453	CDD:275368	2/33 (6%)
		COG5048	457..860	CDD:227381	118/551 (21%)
		C2H2 Zn finger	461..481	CDD:275368	6/22 (27%)
		C2H2 Zn finger	489..509	CDD:275368	5/19 (26%)
		C2H2 Zn finger	517..537	CDD:275368	5/20 (25%)
		C2H2 Zn finger	564..584	CDD:275368	3/19 (16%)
		C2H2 Zn finger	593..613	CDD:275368	7/46 (15%)
		C2H2 Zn finger	648..668	CDD:275368	6/50 (12%)
		C2H2 Zn finger	676..696	CDD:275368	7/55 (13%)
		C2H2 Zn finger	704..724	CDD:275368	6/19 (32%)
		C2H2 Zn finger	732..752	CDD:275368	5/19 (26%)
		C2H2 Zn finger	760..780	CDD:275368	6/20 (30%)
		C2H2 Zn finger	788..808	CDD:275368	8/19 (42%)
		C2H2 Zn finger	816..836	CDD:275368	6/19 (32%)
		C2H2 Zn finger	844..864	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142191
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030