DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and Zfp473

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001276765.1	Gene:	Zfp473 / 243963	MGIID:	2442697	Length:	892	Species:	Mus musculus

Alignment Length:	1003	Identity:	204/1003 - (20%)
Similarity:	329/1003 - (32%)	Gaps:	275/1003 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   978 TQPS-TVQMDVQSNLPVQAADTQ-PQNESANHSPFESPISSPQVQSQIELQMEPQIETQMQPQIE 1040
            :||| |.|.||:..|  :|..|: |:.:|       ||:.|..|:......||  |.:..|...|
Mouse    68 SQPSLTSQPDVREEL--EATSTEVPETKS-------SPLQSGFVEEDFSQIME--IFSNGQLNFE 121

  Fly  1041 TRMQHDVLS--VQSPQN-HQPQVQSHDQSQMQHQIPPQ---IEPQIEVQNQEQNTLQLVPQAQHQ 1099
            ..:..|.|:  :..|:: .:|.: |..:|...||.|..   :.|...:..:|...:...|:....
Mouse   122 ACIGEDWLNSFLGDPESLPRPDI-SDKESPADHQSPESKSGLSPGPPLCTREDAVMSASPEKTLT 185

  Fly  1100 VVPHVQLQSQLVPHVQTQGTTTTVTYEQIYQQHIVQQTVQQSSNKMQVISLPSAGSETTRQWQTQ 1164
            .|...:.:|.|......||      :|:.|:.....::..||.:.:|...|.::|....  |:.|
Mouse   186 PVILKESRSDLSQEDSVQG------HEKPYKCSECGESFSQSHHLIQHWVLHTSGEPPI--WREQ 242

  Fly  1165 QSQQQQQVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVIEQV 1229
            |....|...:               .:.|.|                      |||.|||..
Mouse   243 QRGLSQGAHF---------------PMCPGT----------------------PASYESYTC--- 267

  Fly  1230 NHQQQHCQQQIQMS--QQQHQRQHQQQQAQQQQQPIMI--LIQQPEIQQPVASASNPQQAPLHIY 1290
                |.|.::...:  .|.||:.|..::..:.|....:  |.:.|.::        |.:..|
Mouse   268 ----QECGKRFSQNVYLQWHQKIHTGEKLCKTQSDSNLEGLSRSPSVE--------PGKQRL--- 317

  Fly  1291 NAATSNDVHQMQ----HTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPI 1351
                |.|....:    |.|.|:.....:.:..:.|.:.|             ||  ...:.:.|.
Mouse   318 ----SKDTDSAKPSTIHGQDQEKPPTGESRDQENLHESQ-------------PG--DRPSVLHPK 363

  Fly  1352 PVTAARGRPLTLKCRFCHN-GPRFSSSLEYSRH----------------IIDL----------HP 1389
            |:...: .|...||..|.. |..||.:...::|                :.:|          |.
Mouse   364 PLRHQK-TPTNAKCFRCKKCGETFSGAFHLAKHQRAHAQRLYKCASCPAVFNLSKHCFQHRKSHF 427

  Fly  1390 AVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSG 1454
            ..|...|..|..:|..|:...:|...|...:.|:|.:|...|.....|.:| ||.|
Mouse   428 PSAACECQGCRKSFNWRSSLIKHQAIHKGEKPYKCDECGKAFNHSSTLKIH-QRIH--------- 482

  Fly  1455 AVKVEDVQLQITSERRPR-----GRPYKPRLQLQQHQ-----LQPQQKLQVQQHQQQQKALQQLP 1509
                        |.::|.     |:.:..|..|.:||     .:|        ||....| :...
Mouse   483 ------------SGQKPHKCSECGKAFCRRTDLTEHQRVHSGFRP--------HQCPVCA-RTFN 526

  Fly  1510 QAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQA 1574
            :..|..:.:....::......:..:..:..:|.::|.::                   .|:|
Mouse   527 RPSHLVRHRLRHAEERHFGCAKCKETFIYKEQLERHNKI-------------------HTIE--- 569

  Fly  1575 SPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMP 1639
                     ...:|:.|       .|.|....||....::....:|...|....    |||
Mouse   570 ---------GLYECKQC-------GEHFICRSTLNCHLSIHIRENTSEKVVGQN----SQH---- 610

  Fly  1640 SPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDH-IPP---------A 1694
               ..:....|..|:.......:|....:|...    .|....|...|.|. :.|         .
Mouse   611 ---TEKCFKNTKCRKAPNHSRYLGQHEKIHAQV----TSGECDPCGETYDQSVQPICHQSICAGV 668

  Fly  1695 SPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTIC 1759
            .|:..|.|........||....|:...|..|......|.....|.| |||.|  :|..|:.|..|
Mouse   669 KPSECAEPEKCTRNTSASEHHPSQREPSFKCDIYNRAFKQRAHLSK-HQLIH--ITEKPFKCNEC 730

  Fly  1760 KRGYRMRTALHRHMESHDVE---------------------------GRPYECNICRVRFPRPSQ 1797
            .|.::....|.:|.::|..|                           .:|::|..|...|...:|
Mouse   731 DRAFKQSNYLIQHQKTHTAEKHFECSECGKTFHQRSCLSKHQKIHSGEKPFKCGDCGKAFISGAQ 795

  Fly  1798 LTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTH 1861
            |..|: .:|...||:.|.||||.|...|.|..|::.| ||..|.|..|.:.|......|||.|.|
Mouse   796 LIRHQ-RIHTGEKPYVCQECGKTFSQSSCLTLHLRIHTGEKPYTCGTCGKAFAQRANQRKHERIH 859

  Fly  1862 S-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            : |..|.|..|..:|...|:.:.|.:.|
Mouse   860 TGEKPYACGLCGKAFGLRTHLQQHQRIH 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	7/49 (14%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
Zfp473	NP_001276765.1	KRAB_A-box	23..63	CDD:143639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..97		13/37 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..203		13/69 (19%)
		C2H2 Zn finger	211..231	CDD:275368	3/19 (16%)
		C2H2 Zn finger	267..287	CDD:275368	5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..370		15/103 (15%)
		C2H2 Zn finger	434..454	CDD:275368	5/19 (26%)
		zf-H2C2_2	446..471	CDD:372612	6/24 (25%)
		C2H2 Zn finger	462..482	CDD:275368	7/20 (35%)
		COG5048	485..888	CDD:227381	98/469 (21%)
		C2H2 Zn finger	490..510	CDD:275368	5/19 (26%)
		C2H2 Zn finger	518..538	CDD:275368	2/20 (10%)
		C2H2 Zn finger	546..566	CDD:275368	2/38 (5%)
		C2H2 Zn finger	574..594	CDD:275368	6/26 (23%)
		C2H2 Zn finger	617..637	CDD:275368	3/19 (16%)
		C2H2 Zn finger	645..665	CDD:275368	4/19 (21%)
		C2H2 Zn finger	699..719	CDD:275368	7/20 (35%)
		C2H2 Zn finger	727..747	CDD:275368	5/19 (26%)
		C2H2 Zn finger	755..775	CDD:275368	0/19 (0%)
		C2H2 Zn finger	783..803	CDD:275368	6/20 (30%)
		C2H2 Zn finger	811..831	CDD:275368	9/19 (47%)
		C2H2 Zn finger	839..859	CDD:275368	7/19 (37%)
		C2H2 Zn finger	867..887	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832243
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030