DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp945

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001103724.1	Gene:	Zfp945 / 240041	MGIID:	2445132	Length:	794	Species:	Mus musculus

Alignment Length:	902	Identity:	159/902 - (17%)
Similarity:	282/902 - (31%)	Gaps:	297/902 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1080 IEVQNQEQNTLQLVPQAQHQVVPHVQLQSQLVPHVQTQGTTTTVTYEQIYQQHIVQQTVQQSSNK 1144
            ::|..:..|.|..|....|..|.|        ..|..||:..:.      .:|:   .:|:.|||
Mouse    60 MDVMLENYNNLLFVENNHHVCVKH--------DEVLGQGSKYSA------PEHV---NIQEKSNK 107

  Fly  1145 MQVI---------SLP------SAGSETTRQWQTQQSQQQQQVQWSSVGGLEAIKSAPVESVAPT 1194
            .:..         |.|      .|..|::.:.:|:.:::..:.: ..|.||         ::.|.
Mouse   108 WKECGKMIHESSKSTPYQTNNRDASIESSNRHKTENAREPCKYK-DCVNGL---------NLYPI 162

  Fly  1195 T---TTYYISASD----LYPQQ-TETYTMLQPASNESYVIEQVNHQQQHCQQQ-----IQMSQQQ 1246
            |   .|.|:...:    ||.:. ...|.::...:|...       :...|::.     :..|...
Mouse   163 TCHNQTVYLEIKEHTKTLYDEAFLSKYKLMLKGNNSGM-------KSHKCRKSGKFFTMTSSLSG 220

  Fly  1247 HQRQHQQQQAQQ--QQQPIMILIQQPEIQQPVASASNPQQAP------LHIYNAATSNDVHQMQH 1303
            |.|.|.:::..|  :.....:.:...::...:.....|.:..      .|.........:|..::
Mouse   221 HPRDHAREKPYQCTKCSKSFLHLSHLQLHYKIHFGGYPYKCTECGKCFYHASGFERHCRIHATKN 285

  Fly  1304 TQRQQI------------RQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAA 1356
            |.:...            :.|..|::.:..:..|.||...:...........|..|
Mouse   286 TYKCSFCSKSFICCSGLRKHQKIHEENRLFECNQDTRSFCTFSYRECHYRADIRKK--------- 341

  Fly  1357 RGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQ 1421
                 ..:|:.|......||.|:..:.|   |....|:.|..|..:|..::....|...|.....
Mouse   342 -----CYRCKECGKSLSTSSGLKIHQRI---HTGERPYKCGDCDKSFTQKSNLRMHQKIHTGENT 398

  Fly  1422 YQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPR-----GRPYKPRLQ 1481
            |:|.:|...|..:..|..| ||.|                     |..:|.     |:.:.....
Mouse   399 YKCSECDKCFTQRCLLRTH-QRIH---------------------SGEKPYKCSECGKAFAGGSY 441

  Fly  1482 LQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQ 1546
            |:.||       ::...::..|. ....::.|.:               ..|::         ||
Mouse   442 LRSHQ-------RIHSEKKPYKC-SDCDKSFHRK---------------DHLRI---------HQ 474

  Fly  1547 QVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAP 1611
            ::...::|.:                            |.:|:.|
Mouse   475 RIHTGEKPYK----------------------------CSECDKC-------------------- 491

  Fly  1612 PTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQ-SEPDSTTTLRQYRKRGVIVGPQGPLHLATPVA 1675
               .|...::        .::.:..|...|.: |:.|.:.|.:...|...|:      |......
Mouse   492 ---FTQKGSV--------RIHQRIHTGEKPYKCSKCDKSFTKKDCLKIHQII------HTGEEPY 539

  Fly  1676 SPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTS---------HHCLYCEER 1731
            ..|...: |.:..||                            |||.         :.|..|:|.
Mouse   540 KCSECDT-SFNRKDH----------------------------LRTHQRFHTGERIYKCSECDES 575

  Fly  1732 FTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRP-------------- 1782
            ||.:|:|:.|.::..|   ...|.|:.|.:.:..|..|..|...|..| :|
Mouse   576 FTQKINLRIHQKIHTG---DNSYKCSGCDKSFNRRNHLRTHERIHAGE-KPYNCREFENSFIQTG 636

  Fly  1783 --------------YECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKF 1833
                          |:|..|...|...|.:.:|: .:|...||:.|.||||.|.:.|.|:.|.:.
Mouse   637 SLRIHQRLHSRKKLYKCRECDKSFTSSSYVRIHQ-RIHSGEKPYKCSECGKCFTSGSYLRMHQRI 700

  Fly  1834 H-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            | |:..|:|..||:.|.....||.|:|:|: |..|||..|..||...:..|.|.:.|
Mouse   701 HTGDKPYKCSDCDKCFTQKCSLRIHQRSHTGEKPYKCGNCDRSFTSGSYLRIHQRIH 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1841..1861	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1868..1888	CDD:275368	6/19 (32%)
Zfp945	NP_001103724.1	KRAB	34..92	CDD:214630	10/39 (26%)
		KRAB	34..73	CDD:279668	3/12 (25%)
		C2H2 Zn finger	205..225	CDD:275368	4/19 (21%)
		C2H2 Zn finger	233..253	CDD:275368	0/19 (0%)
		C2H2 Zn finger	261..281	CDD:275368	1/19 (5%)
		C2H2 Zn finger	289..309	CDD:275368	1/19 (5%)
		COG5048	340..754	CDD:227381	110/583 (19%)
		C2H2 Zn finger	345..365	CDD:275368	6/22 (27%)
		zf-H2C2_2	358..382	CDD:290200	7/26 (27%)
		C2H2 Zn finger	373..393	CDD:275368	4/19 (21%)
		C2H2 Zn finger	401..421	CDD:275368	7/20 (35%)
		zf-H2C2_2	414..437	CDD:290200	8/44 (18%)
		C2H2 Zn finger	429..449	CDD:275368	4/26 (15%)
		C2H2 Zn finger	457..477	CDD:275368	4/44 (9%)
		zf-H2C2_2	469..494	CDD:290200	7/84 (8%)
		C2H2 Zn finger	485..505	CDD:275368	4/50 (8%)
		zf-H2C2_2	497..521	CDD:290200	4/31 (13%)
		C2H2 Zn finger	513..533	CDD:275368	5/25 (20%)
		C2H2 Zn finger	541..561	CDD:275368	7/48 (15%)
		C2H2 Zn finger	569..589	CDD:275368	8/19 (42%)
		C2H2 Zn finger	597..617	CDD:275368	5/19 (26%)
		C2H2 Zn finger	625..645	CDD:275368	0/19 (0%)
		C2H2 Zn finger	653..673	CDD:275368	5/20 (25%)
		C2H2 Zn finger	681..701	CDD:275368	9/19 (47%)
		zf-H2C2_2	693..718	CDD:290200	9/24 (38%)
		C2H2 Zn finger	709..729	CDD:275368	8/19 (42%)
		zf-H2C2_2	721..746	CDD:290200	12/24 (50%)
		C2H2 Zn finger	737..757	CDD:275368	6/19 (32%)
		zf-H2C2_2	749..774	CDD:290200	3/9 (33%)
		C2H2 Zn finger	765..785	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100