DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp760

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_030105629.1	Gene:	Zfp760 / 240034	MGIID:	2679257	Length:	671	Species:	Mus musculus

Alignment Length:	754	Identity:	152/754 - (20%)
Similarity:	259/754 - (34%)	Gaps:	227/754 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1211 ETYTMLQPASNESYV-------IEQVNHQQQH-CQQQIQMSQQQHQRQHQQ-QQAQQQQQPIMIL 1266
            |.:..|..|....|:       |..|:.::.| |.:..::..|..:.||.. |:...:.:.:..:
Mouse    25 EEWECLDSAQRALYIDVMLENYINLVSVEKHHMCGKYEKVLDQHSEHQHVNIQEKSYKYKELGKM 89

  Fly  1267 IQQPEIQQPVASASNPQQAPLHIYNAATSNDV---HQMQHTQRQ--------------------- 1307
            :.:.....|..::|..:....:.|..|:....   |...||..:
Mouse    90 VHESSPCTPYNTSSTAENCNKYSYQDASIESSLIRHNSVHTGEELFKYKECGKCLCSNICPNQSI 154

  Fly  1308 -QIRQQYQHQQYQRLQQPQQTRVVQSHPVLG---------MPGATSISTKVTPIPVTAARGRPLT 1362
             .|:.::::.:..:|..... |:||.....|         ....:|:||...    .....:|
Mouse   155 HDIKMEHKYTESDKLCGSTH-RLVQQRTHSGEKAHNCGKCFRSCSSLSTHQR----LHTGEKP-- 212

  Fly  1363 LKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQC 1427
            .||:.|....::.|.|:....|   |....||.|..|...|:..::...|..:|...:.|:|.:|
Mouse   213 WKCKECGKSFKWLSHLKAHCRI---HTGEKPFKCNECDKGFSRLSRLKSHYRTHTGEKPYKCEEC 274

  Fly  1428 SHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPR---------LQLQ 1483
            ...|.....|..| .|.|                    |.|     :|||.:         ..|.
Mouse   275 GKCFSRLSRLKNH-YRIH--------------------TGE-----KPYKCKECGKSFTHCTGLS 313

  Fly  1484 QHQLQPQQKLQV--QQHQQQQ--KALQQLPQAQHH---QQQQQPQLQQEVLQQVQQLQVQVQPQQ 1541
            .|     ||:..  :.|:.:.  |:...|...:.|   ..:::|...:|..:....|      ..
Mouse   314 TH-----QKIHTGEKPHKCKNCGKSFHLLSTLKEHFRVHTREKPYKCKECGKFFHWL------SG 367

  Fly  1542 HQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQ 1606
            .:.|.::                 |        :..||.|      |::|       ::.|.:|.
Mouse   368 LKSHYRI-----------------H--------TGETPYK------CKEC-------DKSFSQLS 394

  Fly  1607 TLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPD----STTTLRQYRKRGVIVGPQGP 1667
            .|::.                    |..|....|.:..|.|    ..|.|::::|
Mouse   395 RLKSH--------------------YRTHTGEKSCKCLECDKYFTQCTALKRHQK---------- 429

  Fly  1668 LHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHC------- 1725
            :|     ....|......|...::                        :|.|::  ||
Mouse   430 IH-----TDEKPYKCEECSKCFYV------------------------LSHLKS--HCRTHTGEK 463

  Fly  1726 -LYCEE--RFTNEIS-LKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECN 1786
             ..|||  :..:::| ||.|:::..|   ..||.|..|.:.:...|||..|.:.|..| :||.|.
Mouse   464 PYKCEECGKCLSQLSKLKSHYRIHTG---EKPYKCKECDKSFTHCTALSTHQKIHTGE-KPYSCK 524

  Fly  1787 ICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEY 1850
            .|...|...|:|..| ..||...||:.|.||||.|...|.||.|.:.| ||..|:|:.||::|.:
Mouse   525 DCGKSFYLLSRLKEH-YRVHTGEKPYNCKECGKFFHWLSNLKRHSRIHTGEKPYKCEECDKSFTH 588

  Fly  1851 LKELRKHRRTHSEMF-YKCKFCPSSFMRFTNFRAHMKTH 1888
            ...|:.|::.|:.:. |||:.|..||...:|.:.|.:.|
Mouse   589 CSSLKAHQKIHAGVKPYKCEECSKSFYWLSNLKTHSRIH 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	5/22 (23%)
		C2H2 Zn finger	1396..1416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1725..1746	CDD:275368	8/31 (26%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	10/19 (53%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	6/19 (32%)
Zfp760	XP_030105629.1	KRAB	12..52	CDD:396083	6/26 (23%)
		C2H2 Zn finger	137..182	CDD:275368	5/45 (11%)
		C2H2 Zn finger	188..207	CDD:275368	3/22 (14%)
		COG5048	211..586	CDD:227381	111/520 (21%)
		C2H2 Zn finger	215..235	CDD:275368	5/22 (23%)
		C2H2 Zn finger	243..263	CDD:275368	4/19 (21%)
		C2H2 Zn finger	271..291	CDD:275368	6/20 (30%)
		C2H2 Zn finger	299..319	CDD:275368	4/24 (17%)
		C2H2 Zn finger	327..347	CDD:275368	3/19 (16%)
		C2H2 Zn finger	355..375	CDD:275368	3/42 (7%)
		C2H2 Zn finger	383..403	CDD:275368	6/46 (13%)
		C2H2 Zn finger	411..431	CDD:275368	5/29 (17%)
		C2H2 Zn finger	439..459	CDD:275368	5/45 (11%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		C2H2 Zn finger	495..515	CDD:275368	6/19 (32%)
		C2H2 Zn finger	523..543	CDD:275368	6/20 (30%)
		C2H2 Zn finger	551..571	CDD:275368	10/19 (53%)
		SFP1	<573..623	CDD:227516	17/49 (35%)
		C2H2 Zn finger	579..599	CDD:275368	6/19 (32%)
		C2H2 Zn finger	607..627	CDD:275368	6/19 (32%)
		zf-H2C2_2	619..644	CDD:404364	3/9 (33%)
		C2H2 Zn finger	635..655	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100