DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and Zfp458

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_017170999.1	Gene:	Zfp458 / 238690	MGIID:	3040691	Length:	790	Species:	Mus musculus

Alignment Length:	697	Identity:	149/697 - (21%)
Similarity:	232/697 - (33%)	Gaps:	210/697 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1352 PVTAARGRPLTL----KCRFCHN-GPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQ 1411
            |....|...:|:    ||..|.. |..|.....|..| ..:|..|..:.|..|..:|...:..|.
Mouse   101 PSDVKRQAAITVHPGGKCYTCKECGKGFEHKKVYQNH-RRIHLRVKSYKCEECGKSFRFPSLLSA 164

  Fly  1412 HILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPY 1476
            |..:|...:.|.|..||..|.....|.|| :|.|...|                         ||
Mouse   165 HKRNHTGQKPYNCEICSKAFHVPSLLSVH-KRIHRVQK-------------------------PY 203

  Fly  1477 K----------PRLQLQQHQL-----QPQQ----------KLQVQQHQQQQ------------KA 1504
            |          |.| |.||::     :|.|          ..::..|::..            ||
Mouse   204 KSEDYGKTLHCPSL-LSQHKIVHTGEKPYQCEDLGKAFRYPSRLSNHKKIHTGEKPHKCEVCGKA 267

  Fly  1505 LQQLPQAQHHQQ---QQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPH 1566
            .....:..:|::   .::| .:.||..:...     .|.:..||:.:...::|.:..:......:
Mouse   268 FDYPSRLSNHKRIHTGEKP-YKCEVCGKAFH-----DPSKLSQHKIIHTGEKPYKCEVCGKTFHY 326

  Fly  1567 PSTVEMQASPTTPRKILCCP-------------------------DCEDCTSGHSHAN--EQFEE 1604
            ||.:.......|...:..|.                         .||||.....:.:  .:.::
Mouse   327 PSILSKHKIIHTKENLCKCDICGKAFHYPLLLSQHKIVHTGEKPYKCEDCGKAFYYPSRLSRHKK 391

  Fly  1605 LQTLQAP--PTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEP-----DSTTTLRQYRKRGVIV 1662
            :.|.:.|  ..|.......:|:.|...:|:::.    :|.:.|.     |..:.|..::|
Mouse   392 IHTGEKPYKCEVCGKAFYYLSILSKHMIVHTEE----NPYKCEVCGKAFDYPSRLSNHKK----- 447

  Fly  1663 GPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLY 1727
                 :|                            |...|                    |.|..
Mouse   448 -----IH----------------------------TEDKP--------------------HKCEV 459

  Fly  1728 CEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRF 1792
            |...|....||:||..:..|   ..||.|.||.:.:...:.|.:|.:.| .|.:||:|.:|...|
Mouse   460 CGNAFCFSSSLRKHKIIHTG---EKPYKCDICGKAFGSPSRLSKHNKIH-TEDKPYKCEVCGKAF 520

  Fly  1793 PRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRK 1856
            ..||.|.:|| .:|...||:.|:.|||.|...|.|..|.:.| ||..|:|:.|.:.|..|..|..
Mouse   521 HFPSLLLVHK-RIHTGEKPYKCEVCGKAFYCLSTLSVHKRIHTGEYAYKCEVCGKAFHCLSTLSV 584

  Fly  1857 HRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDAASKS---PSNNNSH------- 1910
            |:|.|: |..|||:.|..:|...:....|.:.|......:.| ...||   ||..:.|
Mouse   585 HKRIHTQEKPYKCEVCGQAFHASSKLSHHKRIHSGEKPHKCE-ICGKSFYYPSRLSKHKVIHTGE 648

  Fly  1911 ------ASSDKLENPATPIEETPLTPMSSGGHLYHSPDEYPNSVESC 1951
                  ||...|:.|:.  ...|.| :.:|        |.||..|.|
Mouse   649 KPYHSQASGKTLDYPSR--HSKPKT-IKTG--------EKPNKCEIC 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/23 (26%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1725..1746	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	4/19 (21%)
Zfp458	XP_017170999.1	KRAB	43..101	CDD:214630	149/697 (21%)
		transpos_ISL3	110..>157	CDD:411183	12/47 (26%)
		C2H2 Zn finger	121..141	CDD:275368	5/20 (25%)
		C2H2 Zn finger	149..169	CDD:275368	5/19 (26%)
		C2H2 Zn finger	177..197	CDD:275368	8/20 (40%)
		C2H2 Zn finger	209..225	CDD:275368	5/16 (31%)
		C2H2 Zn finger	233..253	CDD:275368	1/19 (5%)
		COG5048	257..727	CDD:227381	109/513 (21%)
		C2H2 Zn finger	261..281	CDD:275368	3/19 (16%)
		C2H2 Zn finger	289..309	CDD:275368	5/24 (21%)
		C2H2 Zn finger	317..337	CDD:275368	2/19 (11%)
		C2H2 Zn finger	345..365	CDD:275368	1/19 (5%)
		C2H2 Zn finger	373..393	CDD:275368	4/19 (21%)
		C2H2 Zn finger	401..421	CDD:275368	3/19 (16%)
		C2H2 Zn finger	429..449	CDD:275368	4/29 (14%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	485..505	CDD:275368	5/19 (26%)
		C2H2 Zn finger	513..533	CDD:275368	8/20 (40%)
		C2H2 Zn finger	541..561	CDD:275368	8/19 (42%)
		C2H2 Zn finger	569..589	CDD:275368	7/19 (37%)
		C2H2 Zn finger	597..617	CDD:275368	4/19 (21%)
		C2H2 Zn finger	625..645	CDD:275368	6/20 (30%)
		C2H2 Zn finger	681..701	CDD:275368	2/4 (50%)
		C2H2 Zn finger	709..729	CDD:275368
		zf-H2C2_2	721..746	CDD:404364
		C2H2 Zn finger	737..757	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100