DRSC/TRiP Functional Genomics Resources

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Protein Alignment mld and Zfp445

DIOPT Version :9

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:NP_001346863.1 Gene:Zfp445 / 235682 MGIID:2143340 Length:998 Species:Mus musculus


Alignment Length:1173 Identity:213/1173 - (18%)
Similarity:353/1173 - (30%) Gaps:373/1173 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   897 EQSSVAEPKDEKPSATEDPFDNSNFTNELIGFQNDIPCFENIETPEEGQNLHLELTQFLRDLQPS 961
            ||..:...|:|:    ||.:         |..|...|  :.:..|  ||.|   ..|..|.|:..
Mouse    17 EQGCLRMVKEEE----EDGY---------ISMQTARP--QTLNRP--GQEL---FRQLFRQLRYH 61

  Fly   962 QSDPP---------------------AGEQVEKIEME----TQPSTVQMDVQSNLPVQAADTQPQ 1001
            :|..|                     ..:.:|.:.:|    ..|..::..||.:.|...|:....
Mouse    62 ESSGPLETLSRLQELCRWWMRPDVLSKAQMLELLVLEQFLSILPGELRTWVQLHCPESGAEVVAL 126

  Fly  1002 NESANHSPFESPISSPQVQSQIELQ------MEP-QI---------ETQMQPQIETRMQHDVLSV 1050
            .|........:|:..|.:....::.      ::| ||         .:.::..:||.....:..|
Mouse   127 LEELQRDLDGTPLKDPCLTQNPDVHWIGTSALQPAQIWSPASHLKNSSALEDHLETSHGIGICDV 191

  Fly  1051 QSPQNHQPQVQSHDQSQMQHQIPPQI---EPQIEVQNQEQNTLQLVPQAQHQVVPHVQLQSQLVP 1112
            .:.|...|.|...|..|::..|..|:   :|.: ::.||..|.|.|.                |.
Mouse   192 LAEQTDSPAVSVPDYFQLEEGIEYQVTASKPLV-IKLQEALTFQDVE----------------VT 239

  Fly  1113 HVQTQGTTTTVTYEQIYQQHIVQQ-----TVQQSSNKMQVISLPSAGSETTRQWQTQ--QSQQQQ 1170
            ..|.:..........:|:..|::.     :|..||.|..:||    ..|..:.|...  ..|.::
Mouse   240 FSQEEWGCLNSAQRNLYRDVILENYGNVVSVVGSSPKPALIS----WLEARKPWGVNICTVQLKR 300

  Fly  1171 QVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVIEQVNHQQQH 1235
            ....:..||...||  |.:.:.....:.||.|........||....:....||:  :|.:..|..
Mouse   301 DADAAPEGGKLQIK--PNKFILKQKPSEYIEACVKTSVSPETSVSEETGLKESF--KQKSRLQTS 361

  Fly  1236 CQQQIQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAATSNDVHQ 1300
            |...|||.:.:......|:..::.:                               ...:||:.:
Mouse   362 CGDSIQMKEMKEGADISQRTGRESE-------------------------------VLRNNDILE 395

  Fly  1301 MQHTQRQQI---RQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLT 1362
            ::|.:...:   |..::|...:..::       .||......|.....|         ..|..:.
Mouse   396 LKHVKCVSVSRKRLSFKHGYDRNFRK-------SSHHYNNKYGEGLRGT---------GEGFGVY 444

  Fly  1363 LKCRFCHNG-PRFSSSLEYSRHIIDLH--PAVAP---FNCPHCPMAFAGRTKRSQHILSHHVVQQ 1421
            .......|| .|:..:...|.|....|  |:.:.   |.|..|..||..|:.|.:|...|..|:.
Mouse   445 QNTGLKENGKDRYGETSRKSWHAHPEHRQPSYSEEGLFQCRVCGKAFKWRSNRIRHEKIHTGVKP 509

  Fly  1422 YQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRG-RPYKPRLQLQ-- 1483
            |||..|...|....:..:|                       |.|..::.|| ..||..|...  
Mouse   510 YQCSLCEKAFQRLSSYRLH-----------------------QKTHSKQKRGSSKYKNALTCSLD 551

  Fly  1484 -QHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQ-HQ 1546
             .|.|..:.:.:.....|..|.......|..||:....:...:..:..:..:.:....:|.: |.
Mouse   552 VSHHLTDRDERKHLHCNQCGKNFSCKSYAIEHQRIHTQEKPYKCTRCRKTFRWKSNFSRHMKLHH 616

  Fly  1547 QVLQVQQPQQQPLMQP--QSPHPSTVEMQASPTTPRKILCCPDCEDC--TSGHSHANEQFEELQT 1607
            :.:..|:.:|:...|.  ||...||||    .|.|        |::|  |.....:..:.:.:.|
Mouse   617 KEVYKQEKRQEDFKQSYRQSQVISTVE----KTFP--------CQNCGKTFTQKKSLIEHQRIHT 669

  Fly  1608 LQAP-------PTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQ 1665
            .:.|       .|.....|.|:.      |..:||.....||               .|.:...|
Mouse   670 GEKPYQCSGCGETFTYRSSYIIH------MKRTQHAIKIKPE---------------HGCLTFSQ 713

  Fly  1666 GPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEE 1730
            |.:.       |.|..|.::                                  ..|:.|.||.:
Mouse   714 GAVF-------PIPRGSHNT----------------------------------EGSNKCKYCGK 737

  Fly  1731 RFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHD------------------ 1777
            .|.|. |....|:..|  ....||.|..|::.:|..:.|:||...|.                  
Mouse   738 AFHNR-SFLLIHERVH--TREKPYQCRECEKAFRWSSNLYRHQRKHFLHKRYKYRESKETSNLQS 799

  Fly  1778 ---VEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH----- 1834
               ::.:|:.|..|...|.|...|..|| .:|...:...|:.|.|.|.....|..|.:.|     
Mouse   800 KILIDQKPFWCQECGKTFTRKRSLLDHK-GIHSGERRFKCNLCEKSFDRNYRLVNHQRIHTTEQP 863

  Fly  1835 ---------------------------------------------------GELGYQCDG----- 1843
                                                               |:|..:||.     
Mouse   864 QWRDKDFVGIHARSVDQRKHSNTLQSEYGLHSDKPGLSYCQDVRLNIQELSGKLRKECDNPSDES 928

  Fly  1844 ---------------------CDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMK 1886
                                 |.:||:....|..|:|.|: |..:||..|..:|...:|...|||
Mouse   929 SKSIAFQNVPTKKKACHKCSTCGKTFKKHSHLISHKRCHTKERPFKCIVCGKTFRWSSNLTRHMK 993

  Fly  1887 THL 1889
            .|:
Mouse   994 NHV 996

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
C2H2 Zn finger 1365..1388 CDD:275368 5/23 (22%)
C2H2 Zn finger 1396..1416 CDD:275368 7/19 (37%)
C2H2 Zn finger 1424..1445 CDD:275368 4/20 (20%)
C2H2 Zn finger 1725..1746 CDD:275368 7/20 (35%)
C2H2 Zn finger 1756..1776 CDD:275368 6/19 (32%)
C2H2 Zn finger 1785..1806 CDD:275368 7/20 (35%)
C2H2 Zn finger 1814..1834 CDD:275368 6/19 (32%)
zf-C2H2 1839..1861 CDD:278523 8/47 (17%)
C2H2 Zn finger 1841..1861 CDD:275368 8/45 (18%)
C2H2 Zn finger 1868..1888 CDD:275368 7/19 (37%)
Zfp445NP_001346863.1 SCAN 48..160 CDD:128708 17/114 (15%)
KRAB 231..289 CDD:214630 14/77 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 445..472 5/26 (19%)
COG5048 <461..611 CDD:227381 34/172 (20%)
C2H2 Zn finger 484..504 CDD:275368 7/19 (37%)
C2H2 Zn finger 512..532 CDD:275368 5/42 (12%)
COG5048 566..995 CDD:227381 91/506 (18%)
C2H2 Zn finger 567..587 CDD:275368 5/19 (26%)
C2H2 Zn finger 595..615 CDD:275368 1/19 (5%)
C2H2 Zn finger 648..668 CDD:275368 3/19 (16%)
C2H2 Zn finger 676..694 CDD:275368 3/23 (13%)
C2H2 Zn finger 732..752 CDD:275368 7/20 (35%)
C2H2 Zn finger 760..780 CDD:275368 6/19 (32%)
C2H2 Zn finger 810..830 CDD:275368 7/20 (35%)
C2H2 Zn finger 838..858 CDD:275368 6/19 (32%)
C2H2 Zn finger 947..967 CDD:275368 6/19 (32%)
C2H2 Zn finger 975..995 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24376
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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