DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp764

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_666315.3	Gene:	Zfp764 / 233893	MGIID:	2443580	Length:	431	Species:	Mus musculus

Alignment Length:	518	Identity:	107/518 - (20%)
Similarity:	165/518 - (31%)	Gaps:	158/518 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1455 AVKVEDVQLQITSER----RPRGRPYKPRLQLQQHQL---------QPQQKLQVQQHQQQQKALQ 1506
            ||...||.:..:.|.    ||..|.....:..:.:.|         :|.....|::..:......
Mouse    21 AVSFADVAVYFSPEEWRCLRPAQRALYREVMRETYGLLASLGLGGAKPALICWVEEESEVWGPCA 85

  Fly  1507 QLPQ-----------AQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQ--QQP 1558
            |.|:           .:|.:::::|:.:.|.:|:.      ..|:..|:..|:.......  |..
Mouse    86 QDPEVAMCRTEVHSDCRHEKERKRPREETEAMQKT------FSPEPGQKEPQLSFAGSASGIQAT 144

  Fly  1559 LMQPQSPH------------PSTVEMQASPTTPRKILCCPDCEDCTSGHS--------HANEQFE 1603
            :::....|            |:.|| .....|..|...||||..|....|        |..|:
Mouse   145 VLRADKRHGCHLCGKSFAQRPTLVE-HLYTHTGEKPFQCPDCNKCFGRASSLTMHRAIHRGER-- 206

  Fly  1604 ELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPL 1668
                                                 |.|. ||..   :.:.:|..:|.
Mouse   207 -------------------------------------PHQC-PDCG---KSFTQRSTLVA----- 225

  Fly  1669 HLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFT 1733
            |:.|.... .|...|.                                           |.:.|:
Mouse   226 HMYTHTGE-KPFCCPD-------------------------------------------CNKSFS 246

  Fly  1734 NEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQL 1798
            ...||..|..:..|   ..|:.|..|.|.:..|:.|..|:..|..| :||.|..|...|.:.|..
Mouse   247 RSSSLSSHRAIHRG---ERPHCCPDCGRAFTRRSGLIAHLRIHTGE-KPYCCADCGRCFSQRSAF 307

  Fly  1799 TLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS 1862
            ..|:..||....|.||..||:.|.....|:.|::.| ||..|.|..|.|.|....|:..|||||:
Mouse   308 REHQRVVHSGVTPFTCTHCGRAFADSKYLRRHMRIHTGEKPYSCPDCGRCFRQSSEIPAHRRTHT 372

  Fly  1863 -EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDAASKSPSNNNSHASSD-KLENPATPI 1923
             |..|.|..|...|...:...:|...|.| |...::|..::..|     .|.| :.|:|..|:
Mouse   373 GERPYPCPQCGRQFRTKSAMTSHQWVHRP-GAKGHKDKKARQLS-----ISLDPRQEDPDPPV 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368
		C2H2 Zn finger	1396..1416	CDD:275368
		C2H2 Zn finger	1424..1445	CDD:275368
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1814..1834	CDD:275368	6/19 (32%)
		zf-C2H2	1839..1861	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1841..1861	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1868..1888	CDD:275368	4/19 (21%)
Zfp764	NP_666315.3	KRAB	22..81	CDD:214630	10/58 (17%)
		KRAB	22..55	CDD:279668	7/32 (22%)
		C2H2 Zn finger	154..174	CDD:275368	3/20 (15%)
		zf-H2C2_2	167..191	CDD:290200	9/24 (38%)
		COG5048	178..>243	CDD:227381	20/156 (13%)
		C2H2 Zn finger	182..202	CDD:275368	6/19 (32%)
		zf-H2C2_2	194..219	CDD:290200	6/67 (9%)
		C2H2 Zn finger	210..230	CDD:275368	5/28 (18%)
		zf-H2C2_2	223..243	CDD:290200	6/68 (9%)
		COG5048	262..>317	CDD:227381	18/55 (33%)
		C2H2 Zn finger	266..286	CDD:275368	6/19 (32%)
		zf-H2C2_2	282..303	CDD:290200	8/21 (38%)
		zf-C2H2	321..343	CDD:278523	7/21 (33%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		zf-H2C2_2	335..360	CDD:290200	10/24 (42%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-H2C2_2	367..388	CDD:290200	10/20 (50%)
		C2H2 Zn finger	379..399	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832245
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930