DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp553

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001347841.1	Gene:	Zfp553 / 233887	MGIID:	2384725	Length:	591	Species:	Mus musculus

Alignment Length:	662	Identity:	139/662 - (20%)
Similarity:	190/662 - (28%)	Gaps:	242/662 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1312 QYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSIST-----------------KVTP-IPVTAARG 1358
            :::|...:| ..|:.....|..|.|.: |.||:..                 |..| .||....|
Mouse     8 EFEHSPQER-DGPEIKEEEQLAPTLQV-GNTSLKPDGIQCWDDLWDRREGLGKRQPRDPVPRILG 70

  Fly  1359 RP--------LTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILS 1415
            .|        ....|..|  |..|....:..:| ...|....|:.|..|...|...:.|.:|..:
Mouse    71 EPRWGQGSNDRAAVCGEC--GKSFRQMSDLVKH-QRTHTGEKPYKCGVCGKGFGDSSARIKHQRT 132

  Fly  1416 HHVVQQYQ------------------------CGQCSHVFPAQKALDVHIQRFHMTLKTDPSG-- 1454
            |...:.|:                        ||:|...|.....|..| ||.|...|....|
Mouse   133 HTGEKAYRVRPPAPGPPKMPRSRIPAGERPTICGECGKSFRQSSDLVKH-QRTHTGEKPYKCGIC 196

  Fly  1455 AVKVEDVQLQITSERRPRG----RPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQ 1515
            .....|...:|..:|..||    ||..||       .||........|:         |:|
Mouse   197 GKGFGDSSARIKHQRTHRGDQLPRPVVPR-------RQPSPAAPAAPHR---------PKA---- 241

  Fly  1516 QQQQPQLQQEV---------LQQVQQLQVQVQP-------------QQHQQHQQVLQVQQPQQQP 1558
             |.:|.:..:.         |...|:..:..:|             ....:|.:|...::|...|
Mouse   242 -QDKPYICTDCGKRFVLSCSLLSHQRSHLGPKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLCP 305

  Fly  1559 -----------------LMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHS--------HA 1598
                             ....|.||                 .||:|....|..|        |.
Mouse   306 ECGKGFADSSARVKHLRTHSGQRPH-----------------ACPECNRSFSLSSTLLRHRLTHV 353

  Fly  1599 NEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVG 1663
            ..|...|......|.:.:||        |.|:..|..:|..||..|.
Mouse   354 EPQDFSLAAYPVVPLIPSPP--------PPPLGTSPSLTPRSPSHSS------------------ 392

  Fly  1664 PQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYC 1728
             .||..|        |...|           .|..|.:..||| |....        ..|.|..|
Mouse   393 -DGPFGL--------PGLEP-----------EPGGPQAGEPPP-PLAGD--------KPHKCPEC 428

  Fly  1729 EERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHD---------------- 1777
            .:.|.....|.|||::..|   ..||:|..|.:|:...:|..:|:.:|.
Mouse   429 GKGFRRSSDLVKHHRVHTG---EKPYLCPECGKGFADSSARVKHLRTHQGERTRPPPPPSTLLRP 490

  Fly  1778 --------------VEGRP------YECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFG 1822
                          |:|||      :.|..|...|||.|.|..|:.| |...||:.|.||||.||
Mouse   491 HNPPGSVPIVPQSRVQGRPSGPSQLHVCGFCGKEFPRSSDLVKHRRT-HTGEKPYKCAECGKGFG 554

  Fly  1823 TESALKTHIKFH 1834
            ..||...|.:.|
Mouse   555 DSSARIKHQRGH 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	5/22 (23%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1725..1746	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	9/20 (45%)
		C2H2 Zn finger	1814..1834	CDD:275368	10/19 (53%)
		zf-C2H2	1839..1861	CDD:278523
		C2H2 Zn finger	1841..1861	CDD:275368
		C2H2 Zn finger	1868..1888	CDD:275368
Zfp553	NP_001347841.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		3/16 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..80		6/24 (25%)
		C2H2 Zn finger	85..105	CDD:275368	5/22 (23%)
		zf-H2C2_2	97..120	CDD:316026	5/23 (22%)
		C2H2 Zn finger	113..133	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..160		2/28 (7%)
		COG5048	161..572	CDD:227381	110/504 (22%)
		C2H2 Zn finger	165..185	CDD:275368	8/20 (40%)
		C2H2 Zn finger	193..213	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..241		12/50 (24%)
		C2H2 Zn finger	248..268	CDD:275368	2/19 (11%)
		C2H2 Zn finger	276..296	CDD:275368	1/19 (5%)
		C2H2 Zn finger	304..324	CDD:275368	1/19 (5%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..429		22/111 (20%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		C2H2 Zn finger	453..538	CDD:275368	19/85 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..512		7/47 (15%)
		C2H2 Zn finger	546..566	CDD:275368	10/19 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..591		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030