DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp62

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001349654.1	Gene:	Zfp62 / 22720	MGIID:	99662	Length:	914	Species:	Mus musculus

Alignment Length:	632	Identity:	136/632 - (21%)
Similarity:	219/632 - (34%)	Gaps:	144/632 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1303 HTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKCRF 1367
            ||....|          :|:|..:|.....:|        |.:|....||..
Mouse    70 HTNAANI----------KLEQDDETSEKSFYP--------STNTMHQTIPTE------------- 103

  Fly  1368 CHNGPRFSSSLEYSRHII-DLHPA-VAP---FNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQC 1427
                |..:...|::.:|. ::||| :|.   ..|..|..:|...::..||.:.|...::|:|..|
Mouse   104 ----PNCTKQGEHTENINGNVHPAHIADKKLHKCDECGKSFKYNSRLVQHKIMHTGEKRYECDDC 164

  Fly  1428 SHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQK 1492
            ...|.:..:|.|| :|.|                    |.|     :|||
Mouse   165 RGTFRSSSSLRVH-KRIH--------------------TGE-----KPYK--------------- 188

  Fly  1493 LQVQQHQQQQKALQQLPQAQHHQQQQQPQLQ------------QEVLQQVQQLQVQVQPQQHQQ- 1544
                 ..:..||........:|:.....:..            ..||.|.:::....:|.:..:
Mouse   189 -----CDECGKAYMSYSSLINHKSTHSGEKNCKCDECGKSFNYSSVLDQHKRIHTGEKPYECGEC 248

  Fly  1545 ------------HQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCP-DCEDCTSGHS 1596
                        |:::...::|.:.........:.|.:.:.....|..|    | :|::|
Mouse   249 GKAFRNSSGLRVHKRIHTGEKPYECDTCGKTFSNSSGLRVHKRIHTGEK----PYECDEC----- 304

  Fly  1597 HANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYS----QHITMPSPEQS-EPDSTTTLRQYR 1656
              .:.|...:||....::.............:...||    ||..:.:.|:. |.|...  :.:|
Mouse   305 --GKAFITCRTLLNHKSIHFGDKPYKCDECEKSFNYSSLLIQHKVIHTGEKPYECDECG--KAFR 365

  Fly  1657 -KRGVIVGPQ---GPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVS 1717
             ..|:||..:   |.......:...:.|.|...:....|.|...|.............:..:|..
Mouse   366 NSSGLIVHKRIHTGEKPYKCDICGKAFSYSSGLAVHKSIHPGKKAHECKDCGKSFSYNSLLLQHK 430

  Fly  1718 ELRTSHH---CLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVE 1779
            .:.|...   |..|.:.|.|...||.|.:|..|   ..||.|.:|.:.|..|::|..|...|..|
Mouse   431 TIHTGERPYVCDVCGKTFRNNSGLKVHRRLHTG---EKPYKCDVCGKAYISRSSLKNHKGIHMGE 492

  Fly  1780 GRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDG 1843
             :||:|:.|...|...|.|..|| .:|...||..||||||.|...|.||.|.:.| ||..|:|:.
Mouse   493 -KPYKCSYCEKSFNYSSALEQHK-RIHTREKPFGCDECGKAFRNNSGLKVHKRIHTGERPYKCEE 555

  Fly  1844 CDRTFEYLKELRKHRRTH-SEMFYKCKFCPSSFMRFTNFRAHMKTHL 1889
            |.:.:..|..|..|:..| .|..:||..|..:|:.:.....|.|.||
Mouse   556 CGKAYISLSSLINHKSVHPGEKPFKCDECEKAFITYRTLLNHKKIHL 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	3/23 (13%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1814..1834	CDD:275368	11/19 (58%)
		zf-C2H2	1839..1861	CDD:278523	6/21 (29%)
		C2H2 Zn finger	1841..1861	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
Zfp62	NP_001349654.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..101		5/28 (18%)
		COG5048	127..542	CDD:227381	98/478 (21%)
		C2H2 Zn finger	133..153	CDD:275368	5/19 (26%)
		C2H2 Zn finger	161..181	CDD:275368	7/20 (35%)
		C2H2 Zn finger	189..209	CDD:275368	3/19 (16%)
		C2H2 Zn finger	217..237	CDD:275368	3/19 (16%)
		C2H2 Zn finger	245..265	CDD:275368	1/19 (5%)
		C2H2 Zn finger	273..293	CDD:275368	1/19 (5%)
		C2H2 Zn finger	301..321	CDD:275368	5/26 (19%)
		C2H2 Zn finger	329..349	CDD:275368	4/19 (21%)
		C2H2 Zn finger	357..377	CDD:275368	5/21 (24%)
		SFP1	<379..458	CDD:227516	14/78 (18%)
		C2H2 Zn finger	385..405	CDD:275368	2/19 (11%)
		C2H2 Zn finger	413..433	CDD:275368	1/19 (5%)
		COG5048	437..850	CDD:227381	61/171 (36%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..517	CDD:275368	7/20 (35%)
		C2H2 Zn finger	525..545	CDD:275368	11/19 (58%)
		C2H2 Zn finger	553..573	CDD:275368	5/19 (26%)
		C2H2 Zn finger	581..601	CDD:275368	5/19 (26%)
		C2H2 Zn finger	609..629	CDD:275368
		C2H2 Zn finger	637..657	CDD:275368
		C2H2 Zn finger	665..685	CDD:275368
		C2H2 Zn finger	693..713	CDD:275368
		C2H2 Zn finger	721..741	CDD:275368
		C2H2 Zn finger	749..769	CDD:275368
		C2H2 Zn finger	777..797	CDD:275368
		C2H2 Zn finger	805..824	CDD:275368
		C2H2 Zn finger	832..852	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100