DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp60

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_033586.2	Gene:	Zfp60 / 22718	MGIID:	99207	Length:	704	Species:	Mus musculus

Alignment Length:	923	Identity:	168/923 - (18%)
Similarity:	289/923 - (31%)	Gaps:	323/923 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1096 AQHQVVPHVQLQSQLVPHVQTQGTTTTVTYEQIYQQHIVQQTVQQSSNKMQVI------------ 1148
            :||.|...|..:...|...|.:......|.:.:| ::|:.:|.   ||.:.|:
Mouse     6 SQHMVCGSVTFRDVAVDFSQEEWACLDATQKVLY-RNIMLETY---SNLVAVVGRCIPKPDLIVL 66

  Fly  1149 ---------------SLPSAGSETTRQWQTQQSQQ------------QQQVQWSSVGGLEAIKSA 1186
                           ..||.|.||..:.:.:..:.            ||..:.|.|.|: ::.:.
Mouse    67 LEQEKEPWMAVKKETGRPSQGLETGFEAENRSPKNHVYNKKLPKQTIQQLSKTSDVQGV-SVSNG 130

  Fly  1187 PVESVAPTTTTYY---ISASDLYPQQTETYTMLQPASN-----------------------ESYV 1225
            |..||......|.   .:.:....::..|||....|.|                       ||..
Mouse   131 PGYSVIKEPQNYQEGDANRNITNKKEMSTYTSKTLAHNKEKPYKCKDCGKCFGCKSNLHQHESIH 195

  Fly  1226 IEQVNHQQQHCQQQIQMSQ--QQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLH 1288
            ..:..::.:.|.:..::.|  .:||:.|..::               ..:..:...|
Mouse   196 TGEKPYECKDCGKTFRLPQMLSRHQKSHSDER---------------PFECNICGKS-------- 237

  Fly  1289 IYNAATSNDVHQMQHTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPV 1353
             ::..|....|:..||..:....:...:.:.|:....|.|.:.:    ||
Mouse   238 -FHLPTLLQYHKNIHTGLKPFECEECGKSFNRISTLFQHRTIHA----GM--------------- 282

  Fly  1354 TAARGRPLTLKCRFCHNGPRF---SSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILS 1415
                 :|  .||..|  |..|   |:.|::.:    :|....||:|..|..||....:.::|...
Mouse   283 -----KP--YKCNVC--GKAFNRRSNLLQHQK----IHSEDRPFHCKVCGKAFTVLAQLTRHENI 334

  Fly  1416 HHVVQQYQCGQCSHVFPAQKAL----DVHIQRFHMTLKTDPSGAVKVEDVQLQITSER----RPR 1472
            |...:.::|.||..:|.....|    |.|                         |:|:    ...
Mouse   335 HTEDKSFECKQCGKIFSNGSYLLRHYDTH-------------------------TNEKPFECNIC 374

  Fly  1473 GRPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQV 1537
            |:.::..|.|.:||         :.|..::....:|.::...::.|        |.:.|::...|
Mouse   375 GKAFRLHLYLSEHQ---------KTHTDEKPFKCKLCESAFRRKYQ--------LSEHQRIHTDV 422

  Fly  1538 QPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQF 1602
            :|.|.:...:..:    ::....:.||.|           |.:|...|.||
Mouse   423 KPYQCKDCGKFFR----RRSNFTEHQSIH-----------TGKKPFECKDC-------------- 458

  Fly  1603 EELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGP 1667
                                      ..|:..:|.:             :|..|
Mouse   459 --------------------------GKVFRLNIHL-------------IRHQR----------- 473

  Fly  1668 LHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSH------HCL 1726
            .|     :...|..........|.                     :.|::..:|||      .|.
Mouse   474 FH-----SDEKPFECKECGKAFHF---------------------SSQLNNHKTSHTGQTPFECK 512

  Fly  1727 YCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVR 1791
            .|.:.|....||.:|..:..|   ..||.|..|.|.:..|:.|.:|.:.|..| ||:||..|...
Mouse   513 ECGKSFKRVSSLVEHRIIHSG---VKPYKCNACGRAFNRRSNLMQHEKIHSDE-RPFECKDCGKA 573

  Fly  1792 FPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFHGEL-GYQCDGCDRTFEYLKELR 1855
            |...:|||.|: |:|...|.:.|::||..|.....|..|.:.|.:: .:||..|.:.|.....||
Mouse   574 FTVLAQLTRHQ-TIHNGKKSYECEQCGSAFRLPYQLTQHQRIHYDVKPFQCKECGKGFVRSTGLR 637

  Fly  1856 KHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDAASKSPSNNNS---------- 1909
            .|.|.|: |..::||.|..:|.....|..|.:.|           ..|:|...:.
Mouse   638 IHERIHTGEKPFQCKECGEAFQYHYQFLGHFRIH-----------TGKNPYECSECGKYFTYGRD 691

  Fly  1910 ---HASSDKLENP 1919
               |.|...||.|
Mouse   692 LKVHQSIHNLEKP 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/25 (24%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/24 (29%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	6/19 (32%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	6/19 (32%)
Zfp60	NP_033586.2	KRAB	14..75	CDD:214630	10/64 (16%)
		KRAB	14..53	CDD:279668	9/42 (21%)
		C2H2 Zn finger	175..195	CDD:275368	2/19 (11%)
		C2H2 Zn finger	203..223	CDD:275368	4/19 (21%)
		COG5048	212..640	CDD:227381	115/635 (18%)
		zf-H2C2_2	215..239	CDD:290200	4/47 (9%)
		C2H2 Zn finger	231..251	CDD:275368	3/28 (11%)
		zf-H2C2_2	244..268	CDD:290200	3/23 (13%)
		C2H2 Zn finger	259..279	CDD:275368	3/19 (16%)
		C2H2 Zn finger	287..307	CDD:275368	6/25 (24%)
		zf-H2C2_2	299..323	CDD:290200	7/27 (26%)
		C2H2 Zn finger	315..335	CDD:275368	5/19 (26%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		zf-H2C2_2	355..378	CDD:290200	6/47 (13%)
		C2H2 Zn finger	371..391	CDD:275368	5/28 (18%)
		C2H2 Zn finger	399..419	CDD:275368	4/27 (15%)
		C2H2 Zn finger	427..447	CDD:275368	2/23 (9%)
		C2H2 Zn finger	455..475	CDD:275368	7/83 (8%)
		zf-H2C2_2	467..491	CDD:290200	4/52 (8%)
		C2H2 Zn finger	483..503	CDD:275368	3/40 (8%)
		C2H2 Zn finger	511..531	CDD:275368	6/19 (32%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		zf-H2C2_2	551..575	CDD:290200	9/24 (38%)
		C2H2 Zn finger	567..587	CDD:275368	8/20 (40%)
		C2H2 Zn finger	595..615	CDD:275368	6/19 (32%)
		C2H2 Zn finger	623..643	CDD:275368	7/19 (37%)
		zf-H2C2_2	636..658	CDD:290200	9/21 (43%)
		C2H2 Zn finger	651..671	CDD:275368	6/19 (32%)
		C2H2 Zn finger	679..699	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100